Diabetes Care:空腹血清果糖水平与中老年2型糖尿病的风险的相关性

2020-07-05 MedSci原创 MedSci原创

空腹血清果糖水平升高与中老年人群发生2型糖尿病的风险增加独立相关。该研究的数据表明较高的空腹血清果糖水平可以作为糖尿病的生物标志物和/或危险因素。

近日,糖尿病领域权威杂志Diabetes Care上发表了一篇研究文章,研究人员旨在调查中国人群的空腹血清果糖水平与发生2型糖尿病的风险之间的关系。

在949名年龄≥40岁且无糖尿病的社区参与者中,研究人员采用液相色谱-串联质谱法测定了空腹血清果糖水平,并对参与者进行糖尿病随访。研究人员进行Cox回归模型以分析空腹血清果糖水平对糖尿病风险的影响。

在平均3.5年的随访中,949名参与者中有179名(18.9%)患了2型糖尿病。空腹血清果糖水平升高以剂量反应方式增加了糖尿病风险。在调整了年龄、性别、BMI、血脂谱、血压、肝功能、吸烟和饮酒状态、基线葡萄糖水平以及含糖饮料后,空腹果糖水平升高1个SD糖尿病风险增加了35%(95%CI为1.08–1.67)。在进一步调整血清尿酸和估计的肾小球滤过率后,这种关联被部分减弱(风险比为1.33 [95%CI为1.07–1.65])。年龄、糖尿病前期状态、BMI和糖尿病家族史的相关性相似,但是女性中的相关性有所减弱(异质性P=0.037)。

由此可见,空腹血清果糖水平升高与中老年人群发生2型糖尿病的风险增加独立相关。该研究的数据表明较高的空腹血清果糖水平可以作为糖尿病的生物标志物和/或危险因素。

原始出处:

Ying Chen.et al.Fasting Serum Fructose Levels Are Associated With Risk of Incident Type 2 Diabetes in Middle-Aged and Older Chinese Population.Diabetes Care.2020.https://care.diabetesjournals.org/content/early/2020/06/29/dc19-2494

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    2021-04-18 zhouqu_8
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    2020-08-31 www.kangshiyizs

    果糖

    0

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    2020-07-05 misszhang

    谢谢MedSci提供最新的资讯

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    2020-07-05 cmn

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