Int J Med Sci:中国200余万高血压门诊患者合并症分析:华北地区合并高血脂症和冠心病者比例高

2017-04-05 卢芳 中国循环杂志

近期,一项由中美学者在全国29家医院200多万高血压患者中进行的研究显示,18%合并糖尿病,9.2%合并高脂血症,14.1%合并冠心病。研究显示,与女性高血压患者相比,男性高血压伴糖尿病的风险增加6%,伴血脂异常的风险增加13%,伴冠心病的风险增17%。此外,值得注意的是,45~59岁的中年高血压人群血脂异常患病率明显要高于<44岁和≥60岁者。口袋里的钱,也会影响高血压及其合并症的流行。研究显示

近期,一项由中美学者在全国29家医院200多万高血压患者中进行的研究显示,18%合并糖尿病,9.2%合并高脂血症,14.1%合并冠心病。

研究显示,与女性高血压患者相比,男性高血压伴糖尿病的风险增加6%,伴血脂异常的风险增加13%,伴冠心病的风险增17%。

此外,值得注意的是,45~59岁的中年高血压人群血脂异常患病率明显要高于<44岁和≥60岁者。

口袋里的钱,也会影响高血压及其合并症的流行。研究显示,高收入人群占整个高血压人群的68.24%,还有七成伴有糖尿病,77.39%血脂异常,57.32%合并冠心病。

不过,相比与低收入高血压人群,高收入高血压患者冠心病罹患率偏低;伴发糖尿病情况不受收入影响。而合并血脂异常风险要高出2倍左右。

研究者推测,中年人以及高收入高血压人群由于工作原因,多活动少、聚餐多,从而血脂异常较为多见。其中,高收入人群冠心病患病率低,或是由于比低收入人群看病早干预早的缘故。

研究还显示,那些有糖尿病和冠心病的高血压患者多更倾向于去三甲医院就诊。

从地理区域来看,在总的高血压伴糖尿病患者中,华东地区比例最高占35.29%;而在总的高血压合并高血脂者中,华北地区占比最高为69.82%,此外,合并冠心病高血压患者中,华北占比也为首,达40.16%。

图1  全国29个城市29家医院高血压患者合并症流行状况

进一步分析显示,华南和华北高血压患者血脂异常风险更高;华南和华东高血压患者冠心病风险更高。

研究者认为,经济效力在其中起到一定影响作用,快速发展的经济同时也会激发高脂饮食、不健康生活方式和更大压力的流行。

该研究的数据来自2011-01至2013-12期间,全国29个城市29家医院的电子病历,包括2,122,703位高血压门诊患者。其中高低收入的定义为,是否高于全国人均收入水平。

原始出处:

Wang J, Ma JJ, Liu J, et al. Prevalence and Risk Factors of Comorbidities among Hypertensive Patients in China. Int J Med Sci. 2017, 14.

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    2017-04-07 freve
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20-羟基二十碳四烯酸(20-HETE)是细胞色素P450类花生酸之一,是一种有效的血管活性脂质,其血管作用包括促进平滑肌细胞收缩,迁移和增殖,并与内皮细胞功能障碍和炎症相关。实验动物和人体中20-HETE水平升高与高血压,中风,心肌梗死和血管疾病等相关。近来来自纽约医科大学的学者发表研究型文章《20-羟基二十碳四烯酸信号通过G蛋白偶联受体GPR75(Gq)影响血管功能、触发高血压》于著名血管杂志