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Int J Nanomed：氧化石墨烯可激活自噬潮，用于神经退行性疾病的治疗

2017-12-04 MedSci MedSci原创

神经退行性疾病自噬潮石墨烯
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氧化石墨烯（GO）是一种具有新的生物应用的纳米材料。已知自噬是与神经变性疾病进展有关的细胞内降解系统。尽管既往研究显示GO可诱导自噬潮，但是其在神经退行性疾病中潜在的信号传导通路以及如何参与神经保护仍尚未可知。本研究表明，GO本身可激活神经元细胞中的自噬潮，并赋予对朊蛋白（PrP）（106-126）介导的神经毒性的神经保护作用。在SK-N-SH神经元细胞中可以检测到GO，它触发自噬信号传导。GO诱

氧化石墨烯（GO）是一种具有新的生物应用的纳米材料。已知自噬是与神经变性疾病进展有关的细胞内降解系统。尽管既往研究显示GO可诱导自噬潮，但是其在神经退行性疾病中潜在的信号传导通路以及如何参与神经保护仍尚未可知。

本研究表明，GO本身可激活神经元细胞中的自噬潮，并赋予对朊蛋白（PrP）（106-126）介导的神经毒性的神经保护作用。在SK-N-SH神经元细胞中可以检测到GO，它触发自噬信号传导。GO诱导的自噬潮阻止了PrP（106-126）诱导的SK-N-SH细胞的神经毒性。

此外，自噬潮失活阻止GO诱导的对朊病毒介导的线粒体神经毒性的神经保护作用。本研究是第一个证明GO调节神经元细胞自噬潮且GO诱导的自噬潮信号激活对朊病毒介导的线粒体神经毒性起着神经保护作用。

综上所述，这些结果表明，纳米材料GO可用于激活自噬潮，并可用于治疗神经退行性疾病（包括朊病毒疾病）的神经保护。

原始出处：

Jeong JK, Lee YJ, et al., Autophagic flux induced by graphene oxide has a neuroprotective effect against human prion protein fragments. Int J Nanomedicine. 2017 Nov 8;12:8143-8158. doi: 10.2147/IJN.S146398. eCollection 2017.

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    2018-06-04 ms7899726347904398

    #化石#

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    2018-05-02 ZGMFX35A

    #退行性疾病#

    0

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    2018-11-17 12498b37m72暂无昵称

    #神经退行#

    0

  4. 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topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo5nmIH5IQqCKjJgSCuicPWUWOUcdqt1ROPnEiaOYN4pSHibDv8la3OxNLalvuvUXn8clpJlrpuyTpckgt9OPkeSSdT/0, createdBy=8fd71930726, createdName=半夏微凉, createdTime=Wed Dec 06 08:59:17 CST 2017, time=2017-12-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1608320, encodeId=9cbf1608320ae, content=<a href='/topic/show?id=eb6b1145939' target=_blank style='color:#2F92EE;'>#Med#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11459, encryptionId=eb6b1145939, topicName=Med)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=552a19396740, createdName=ms3994565386320060, createdTime=Wed Dec 06 07:06:00 CST 2017, time=2017-12-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=266797, encodeId=a65b266e9702, content=学了....., beContent=null, objectType=article, channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4Neru1qt53a14aACuSzg3TZhkTcsPYVibyHibhTZ5L4k9qIBWiaej4lgomIsGptf8N16E4mTuIq2DVdJXjPjmwZKrLib/0, createdBy=5a0f2055853, createdName=135****7952平儿, createdTime=Mon Dec 04 20:18:20 CST 2017, time=2017-12-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=266778, encodeId=b09f266e78ac, content=学习了受益匪浅, beContent=null, objectType=article, channel=null, level=null, likeNumber=49, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/ajNVdqHZLLDicHg2ldsSNmib46PmdzpO7CQEmPjuULp1v45zPWwMYhrnXgvl3OtmUCZSQfgITWn96X9moL94nUGA/0, createdBy=28072041016, createdName=131****1460, createdTime=Mon Dec 04 19:26:25 CST 2017, time=2017-12-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=266763, encodeId=cd2e266e6348, content=学习一下谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=54, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzaiabIFicf63hKvVMjL6aJlx4yX4UcXmzX9DyibCRcicq0QtCRWMaQKh8MYjE1D3EKUBopgiaGWYuqbeR/0, createdBy=0c2b1999806, createdName=三生有幸9135, createdTime=Mon Dec 04 16:38:49 CST 2017, time=2017-12-04, status=1, ipAttribution=)]
    2018-06-10 yangjxjc

    #石墨烯#

    0

  5. 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content=学了....., beContent=null, objectType=article, channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4Neru1qt53a14aACuSzg3TZhkTcsPYVibyHibhTZ5L4k9qIBWiaej4lgomIsGptf8N16E4mTuIq2DVdJXjPjmwZKrLib/0, createdBy=5a0f2055853, createdName=135****7952平儿, createdTime=Mon Dec 04 20:18:20 CST 2017, time=2017-12-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=266778, encodeId=b09f266e78ac, content=学习了受益匪浅, beContent=null, objectType=article, channel=null, level=null, likeNumber=49, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/ajNVdqHZLLDicHg2ldsSNmib46PmdzpO7CQEmPjuULp1v45zPWwMYhrnXgvl3OtmUCZSQfgITWn96X9moL94nUGA/0, createdBy=28072041016, createdName=131****1460, createdTime=Mon Dec 04 19:26:25 CST 2017, time=2017-12-04, status=1, 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    2017-12-06 三生有幸9135

    学习一下谢谢分享

    0

  6. 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ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=266763, encodeId=cd2e266e6348, content=学习一下谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=54, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzaiabIFicf63hKvVMjL6aJlx4yX4UcXmzX9DyibCRcicq0QtCRWMaQKh8MYjE1D3EKUBopgiaGWYuqbeR/0, createdBy=0c2b1999806, createdName=三生有幸9135, createdTime=Mon Dec 04 16:38:49 CST 2017, time=2017-12-04, status=1, ipAttribution=)]
    2017-12-06 半夏微凉

    学习了谢谢分享

    0

  7. 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content=学了....., beContent=null, objectType=article, channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4Neru1qt53a14aACuSzg3TZhkTcsPYVibyHibhTZ5L4k9qIBWiaej4lgomIsGptf8N16E4mTuIq2DVdJXjPjmwZKrLib/0, createdBy=5a0f2055853, createdName=135****7952平儿, createdTime=Mon Dec 04 20:18:20 CST 2017, time=2017-12-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=266778, encodeId=b09f266e78ac, content=学习了受益匪浅, beContent=null, objectType=article, channel=null, level=null, likeNumber=49, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/ajNVdqHZLLDicHg2ldsSNmib46PmdzpO7CQEmPjuULp1v45zPWwMYhrnXgvl3OtmUCZSQfgITWn96X9moL94nUGA/0, createdBy=28072041016, createdName=131****1460, createdTime=Mon Dec 04 19:26:25 CST 2017, time=2017-12-04, status=1, 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    2017-12-06 ms3994565386320060

    #Med#

    0

  8. 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content=学了....., beContent=null, objectType=article, channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4Neru1qt53a14aACuSzg3TZhkTcsPYVibyHibhTZ5L4k9qIBWiaej4lgomIsGptf8N16E4mTuIq2DVdJXjPjmwZKrLib/0, createdBy=5a0f2055853, createdName=135****7952平儿, createdTime=Mon Dec 04 20:18:20 CST 2017, time=2017-12-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=266778, encodeId=b09f266e78ac, content=学习了受益匪浅, beContent=null, objectType=article, channel=null, level=null, likeNumber=49, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/ajNVdqHZLLDicHg2ldsSNmib46PmdzpO7CQEmPjuULp1v45zPWwMYhrnXgvl3OtmUCZSQfgITWn96X9moL94nUGA/0, createdBy=28072041016, createdName=131****1460, createdTime=Mon Dec 04 19:26:25 CST 2017, time=2017-12-04, status=1, 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    2017-12-04 135****7952平儿

    学了.....

    0

  9. 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content=学了....., beContent=null, objectType=article, channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4Neru1qt53a14aACuSzg3TZhkTcsPYVibyHibhTZ5L4k9qIBWiaej4lgomIsGptf8N16E4mTuIq2DVdJXjPjmwZKrLib/0, createdBy=5a0f2055853, createdName=135****7952平儿, createdTime=Mon Dec 04 20:18:20 CST 2017, time=2017-12-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=266778, encodeId=b09f266e78ac, content=学习了受益匪浅, beContent=null, objectType=article, channel=null, level=null, likeNumber=49, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/ajNVdqHZLLDicHg2ldsSNmib46PmdzpO7CQEmPjuULp1v45zPWwMYhrnXgvl3OtmUCZSQfgITWn96X9moL94nUGA/0, createdBy=28072041016, createdName=131****1460, createdTime=Mon Dec 04 19:26:25 CST 2017, time=2017-12-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=266763, encodeId=cd2e266e6348, content=学习一下谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=54, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzaiabIFicf63hKvVMjL6aJlx4yX4UcXmzX9DyibCRcicq0QtCRWMaQKh8MYjE1D3EKUBopgiaGWYuqbeR/0, createdBy=0c2b1999806, createdName=三生有幸9135, createdTime=Mon Dec 04 16:38:49 CST 2017, time=2017-12-04, status=1, ipAttribution=)]
    2017-12-04 131****1460

    学习了受益匪浅

    0

  10. 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    2017-12-04 三生有幸9135

    学习一下谢谢分享

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