J Aller Cl Imm-Pract:病毒引起的严重哮喘急性发作成年患者血清IgG浓度的意义

2019-01-15 xing.T MedSci原创

由此可见,当哮喘急性发作时血清IgG显著降低与病毒样本阳性相关。血清IgG浓度较低的患者需要更长的住院时间和更长的类固醇疗程。

患有严重哮喘急性发作的患者的生活质量较差,发病率和死亡率也会增加。病毒经常参与哮喘急性发作。近日,过敏性疾病领域权威杂志Journal of Allergy and Clinical Immunology-In Practice上发表了一篇研究文章,该研究的目的是评估哮喘急性发作期间测定的血清免疫球蛋白G(IgG)浓度及其与哮喘住院患者的病毒感染之间的关系。

2015年1月1日至12月31日,研究人员纳入了哮喘急性住院的患者进行了观察性研究。入院时血清IgG浓度与上呼吸道病毒样本阳性患者和病毒样本阴性患者进行了比较。

在82例患者中,病毒性鼻咽样本阳性者(n=40)在恶化期间血清IgG浓度低于病毒样本阴性者(n=42)(10.1±2.3 g/l vs. 11.5±3.6 g/l,p<0.05)。住院超过3天的患者血清IgG中位数浓度低于住院时间少于3天的患者(10.0g/l[8.2-12.4] vs. 11.4g/l[10.1-12.8],p<0.05),与接受口服类固醇治疗治疗小于5天的患者相比,接受口服皮质类固醇治疗超过5天的患者血清IgG中位数浓度较低(10.1 [8.3-12.2] vs. 11.6 g/l [10.0-13.8],p<0.05)。

由此可见,当哮喘急性发作时血清IgG显著降低与病毒样本阳性相关。血清IgG浓度较低的患者需要更长的住院时间和更长的类固醇疗程。

原始出处:


Morgane Verduyn,et al.Serum IgG concentrations in adult patients experiencing virus-induced severe asthma exacerbations. J Aller Cl Imm-Pract. 2019. https://doi.org/10.1016/j.jaip.2018.12.028

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    2019-01-17 膀胱癌
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    2019-01-16 龙湖胤龙湖玮骗钱

    挺好的文章,参考学习一下

    0

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流感病毒是造成人和动物呼吸道感染的重要病原,该病毒传染性强,且容易发生变异导致感染人或动物的高死亡率。金刚烷胺、奥司他韦及扎那米韦是目前较为常用并能有效抑制流感病毒的药物,但由于流感病毒毒株容易发生变异,造成这些药物的有效性在不断减弱。

J Virol:武汉病毒所在人博卡病毒结构蛋白表达调控方面取得新进展

人博卡病毒隶属于细小病毒科博卡病毒属,具有单链的线性DNA基因组,长度为5-6 kb,病毒颗粒大小约为25 nm。人博卡病毒有四个亚型,其中I型博卡病毒(HBoV1)感染后将引发人类多种呼吸道相关疾病,严重如肺炎、急性哮喘将导致患者死亡,而抗病毒疫苗的研发还未取得有效进展。