Am Heart J :慢性肾脏疾病&急性肾损伤:对冠状动脉旁路移植术患者死亡率具有协同作用

2015-03-11 张旭栋译 MedSci原创

韩国国立首尔大学医学院Seung Seok Han博士等人研究了慢性肾脏疾病(CKD)和急性肾损伤对于行冠状动脉旁路移植术患者死亡率之间的影响,谈论了两者对于GABG术后死亡率的影响,并不是相互排斥,而是相互协同的,其成果发表在3月份American heart journal期刊上。 背景:行冠状动脉旁路移植术(CABG)患者中,急性肾损伤(AKI)和慢性肾脏病(CKD)都是两个备受重视的

韩国国立首尔大学医学院Seung Seok Han博士等人研究了慢性肾脏疾病(CKD)和急性肾损伤对于行冠状动脉旁路移植术患者死亡率之间的影响,谈论了两者对于GABG术后死亡率的影响,并不是相互排斥,而是相互协同的,其成果发表在3月份American heart journal期刊上。

背景:行冠状动脉旁路移植术(CABG)患者中,急性肾损伤(AKI)和慢性肾脏病(CKD)都是两个备受重视的问题,特别是与死亡率的关联。然而,它们对于长期死亡率的协同或离散效应仍旧未知。
 
方法:研究纳入1899例行状动脉搭桥术患者,并对其进行回顾性分析,计算全因死亡率调整后的风险比。应用交互效应超额相对危险度,评估AKI和CKD之间的协同效应。
 
结果:单独AKI的死亡风险比为1.84(1.464-2.319);单独 CKD的死亡风险比为2.46(1.735-3.478);AKI和CKD疾病同时存在时,死亡风险比为3.21(2.301-4.488),与单独AKI或单独CKD相比,死亡风险比有所升高。然而,根据时间长短来分,AKI和CKD与死亡率之间又有所差别:AKI主要影响早期死亡率,特别是在头3年内,而CKD在早期和晚期阶段对死亡率都有影响。从交互效应超额相对危险度来看,AKI和CKD对早期死亡率有协同作用。
 
结论:AKI和CKD对GABG术后死亡率影响有所不同,然而,它们之间的作用并不是相互排斥的,而是相互协同的。

原始出处:
 
Han SS, Shin N, Baek SH, Ahn SY, Kim DK, Kim S, Chin HJ, Chae DW, Na KY. Effects of acute kidney injury and chronic kidney disease on long-term mortality after coronary artery bypass grafting. American heart journal. 2015;169(3):419-25

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    2015-03-13 zhaojie88
  6. [GetPortalCommentsPageByObjectIdResponse(id=1998877, encodeId=be5e19988e71a, content=<a href='/topic/show?id=8e2ee5200ee' target=_blank style='color:#2F92EE;'>#移植术#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=75200, encryptionId=8e2ee5200ee, topicName=移植术)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=63a4277, createdName=cy0324, createdTime=Mon Feb 08 04:26:00 CST 2016, time=2016-02-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1983454, encodeId=0393198345492, content=<a href='/topic/show?id=628553048e3' target=_blank style='color:#2F92EE;'>#患者死亡#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=53048, encryptionId=628553048e3, topicName=患者死亡)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=12de429, createdName=sunylz, createdTime=Thu Oct 01 23:26:00 CST 2015, time=2015-10-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2018963, encodeId=6a9d20189636f, content=<a href='/topic/show?id=b2f35881810' target=_blank style='color:#2F92EE;'>#旁路移植术#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=41, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=58818, encryptionId=b2f35881810, topicName=旁路移植术)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c8f4467, createdName=AspirantSuo, createdTime=Fri Jun 19 15:26:00 CST 2015, time=2015-06-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1355480, encodeId=bf771355480d7, content=<a href='/topic/show?id=f0ff308e898' target=_blank style='color:#2F92EE;'>#冠状动脉旁路移植术#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=30878, encryptionId=f0ff308e898, topicName=冠状动脉旁路移植术)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=zhaojie88, createdTime=Fri Mar 13 00:26:00 CST 2015, time=2015-03-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1355977, encodeId=5e9f13559e7ef, content=<a href='/topic/show?id=b0702e84b9' target=_blank style='color:#2F92EE;'>#ART#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2784, encryptionId=b0702e84b9, topicName=ART)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=zhaojie88, createdTime=Fri Mar 13 00:26:00 CST 2015, time=2015-03-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1396908, encodeId=463f139690812, content=<a href='/topic/show?id=8bee565436d' target=_blank style='color:#2F92EE;'>#损伤#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=56543, encryptionId=8bee565436d, topicName=损伤)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4dfa37, createdName=智者为医08, createdTime=Fri Mar 13 00:26:00 CST 2015, time=2015-03-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1562302, encodeId=49c815623028c, content=<a href='/topic/show?id=f69d864413' target=_blank style='color:#2F92EE;'>#HEART#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=8644, encryptionId=f69d864413, topicName=HEART)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=80d715270048, createdName=slcumt, createdTime=Fri Mar 13 00:26:00 CST 2015, time=2015-03-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1616064, encodeId=29c0161606431, content=<a href='/topic/show?id=9c95536521c' target=_blank style='color:#2F92EE;'>#慢性肾脏#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=53652, encryptionId=9c95536521c, topicName=慢性肾脏)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=305019728622, createdName=12498b08m96暂无昵称, createdTime=Fri Mar 13 00:26:00 CST 2015, time=2015-03-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=18107, encodeId=9a691810ea3, content=明白了, beContent=null, objectType=article, channel=null, level=null, likeNumber=132, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=hbwang006, createdTime=Wed Mar 11 14:51:00 CST 2015, time=2015-03-11, status=1, ipAttribution=)]
  7. [GetPortalCommentsPageByObjectIdResponse(id=1998877, encodeId=be5e19988e71a, content=<a href='/topic/show?id=8e2ee5200ee' target=_blank style='color:#2F92EE;'>#移植术#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=75200, encryptionId=8e2ee5200ee, topicName=移植术)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=63a4277, createdName=cy0324, createdTime=Mon Feb 08 04:26:00 CST 2016, time=2016-02-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1983454, encodeId=0393198345492, content=<a href='/topic/show?id=628553048e3' target=_blank style='color:#2F92EE;'>#患者死亡#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=53048, encryptionId=628553048e3, topicName=患者死亡)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=12de429, createdName=sunylz, createdTime=Thu Oct 01 23:26:00 CST 2015, time=2015-10-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2018963, encodeId=6a9d20189636f, content=<a href='/topic/show?id=b2f35881810' target=_blank style='color:#2F92EE;'>#旁路移植术#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=41, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=58818, encryptionId=b2f35881810, topicName=旁路移植术)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c8f4467, createdName=AspirantSuo, createdTime=Fri Jun 19 15:26:00 CST 2015, time=2015-06-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1355480, encodeId=bf771355480d7, content=<a href='/topic/show?id=f0ff308e898' target=_blank style='color:#2F92EE;'>#冠状动脉旁路移植术#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=30878, encryptionId=f0ff308e898, topicName=冠状动脉旁路移植术)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=zhaojie88, createdTime=Fri Mar 13 00:26:00 CST 2015, time=2015-03-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1355977, encodeId=5e9f13559e7ef, content=<a href='/topic/show?id=b0702e84b9' target=_blank style='color:#2F92EE;'>#ART#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2784, encryptionId=b0702e84b9, topicName=ART)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=zhaojie88, createdTime=Fri Mar 13 00:26:00 CST 2015, time=2015-03-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1396908, encodeId=463f139690812, content=<a href='/topic/show?id=8bee565436d' target=_blank style='color:#2F92EE;'>#损伤#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=56543, encryptionId=8bee565436d, topicName=损伤)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4dfa37, createdName=智者为医08, createdTime=Fri Mar 13 00:26:00 CST 2015, time=2015-03-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1562302, encodeId=49c815623028c, content=<a href='/topic/show?id=f69d864413' target=_blank style='color:#2F92EE;'>#HEART#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=8644, encryptionId=f69d864413, topicName=HEART)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=80d715270048, createdName=slcumt, createdTime=Fri Mar 13 00:26:00 CST 2015, time=2015-03-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1616064, encodeId=29c0161606431, content=<a href='/topic/show?id=9c95536521c' target=_blank style='color:#2F92EE;'>#慢性肾脏#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=53652, encryptionId=9c95536521c, topicName=慢性肾脏)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=305019728622, createdName=12498b08m96暂无昵称, createdTime=Fri Mar 13 00:26:00 CST 2015, time=2015-03-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=18107, encodeId=9a691810ea3, content=明白了, beContent=null, objectType=article, channel=null, level=null, likeNumber=132, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=hbwang006, createdTime=Wed Mar 11 14:51:00 CST 2015, time=2015-03-11, status=1, ipAttribution=)]
    2015-03-13 slcumt
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    2015-03-11 hbwang006

    明白了

    0

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