Chest:限制性肺功能模式与动脉僵硬度增加有关!

2017-04-15 xing.T MedSci原创

限制性肺功能模式和减少的FVC与较高的动脉硬化风险相关,不仅在男性中存在,而且在女性中也同样存在。临床上,再限制性肺功能模式患者中应考虑进行动脉僵硬度的评价。

有越来越多的证据表明肺功能受损与心血管事件和死亡相关。一些研究表明用力肺活量(FVC)水平与动脉僵硬度显著负相关,但大多数研究仅限于男性,并且尚未有研究评估动脉僵硬度与限制性肺功能模式之间的相关性。近日,呼吸疾病领域权威杂志Chest杂志上发表了一篇研究文章,研究人员旨在探讨限制性肺功能模式与动脉僵硬度之间的相关性。

该研究纳入了2961例受试者,除外一下患者:1)慢性阻塞性肺疾病患者,通过肺功能检测和病史来定义;2)哮喘史、肺癌、肺结核、冠心病、脑卒中或任何肺结构畸形;3)药物影响血压、血糖、血脂、肺功能检查。限制性肺功能模式被诊断为FVC预测值<80%,以及FEV1/FVC比值≥70%。动脉僵硬度增加定义为右肱踝脉搏波传导速度(baPWV)≥1400cm/s。

研究人员发现男性和女性FCV均与baPWV水平呈负相关。在男性和女性中,限制性肺功能模式与动脉僵硬度增加呈正相关(男性比值比:2.16,95%可信区间:1.33-3.50;女性比值比:1.95,95%可信区间:1.02-3.72),在对其他临床变量进行调整后。

限制性肺功能模式和减少的FVC与较高的动脉硬化风险相关,不仅在男性中存在,而且在女性中也同样存在。临床上,再限制性肺功能模式患者中应考虑进行动脉僵硬度的评价。

原始出处:

I-Hsuan Wu, et al. Restrictive Spirometry Pattern is Associated with Increased Arterial Stiffness in Men and Women.Chest. 2017. http://journal.publications.chestnet.org/article.aspx?articleid=2619004

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    2017-04-16 qjzhai1623

    长知识

    0

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    2017-04-16 明天会更好!

    学习了,增长了知识。

    0

  7. [GetPortalCommentsPageByObjectIdResponse(id=1929310, encodeId=3c22192931087, content=<a href='/topic/show?id=9e604625ab' target=_blank style='color:#2F92EE;'>#Chest#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4625, encryptionId=9e604625ab, topicName=Chest)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c48a270, createdName=Smile2680, createdTime=Fri Mar 16 09:52:00 CST 2018, time=2018-03-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2050644, encodeId=893f205064496, content=<a href='/topic/show?id=95f8e042dd' target=_blank style='color:#2F92EE;'>#EST#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=20, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7042, encryptionId=95f8e042dd, topicName=EST)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e9a6357, createdName=xiangyuzhou971, createdTime=Mon Jul 03 17:52:00 CST 2017, time=2017-07-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1546731, encodeId=063a1546e3147, content=<a href='/topic/show?id=de1233215db' target=_blank style='color:#2F92EE;'>#动脉僵硬#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=33215, encryptionId=de1233215db, topicName=动脉僵硬)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=b48f13938152, createdName=dlwang_26703131, createdTime=Mon Apr 17 05:52:00 CST 2017, time=2017-04-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1546794, encodeId=66a01546e9401, content=<a href='/topic/show?id=96a0332168b' target=_blank style='color:#2F92EE;'>#动脉僵硬度#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=21, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=33216, encryptionId=96a0332168b, topicName=动脉僵硬度)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=eb8013942519, createdName=1696533704_45270458, createdTime=Mon Apr 17 05:52:00 CST 2017, time=2017-04-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=187780, encodeId=3af318e780b4, content=长知识, beContent=null, objectType=article, channel=null, level=null, likeNumber=45, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/AiafG5m7kibldQyTnpaQicxg1rnBqFdIGgQBJJs4lR8ibmh91PibzgL7R7pl2HSBjgFeeKRV0mMCvDh49LrgJPCYYvA/132, createdBy=abc91707732, createdName=qjzhai1623, createdTime=Sun Apr 16 00:37:10 CST 2017, time=2017-04-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=187764, encodeId=51ea18e76418, content=学习了,增长了知识。, beContent=null, objectType=article, channel=null, level=null, likeNumber=46, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160914/IMG57D82E721DB581755.jpg, createdBy=4fc81933929, createdName=明天会更好!, createdTime=Sun Apr 16 00:03:36 CST 2017, time=2017-04-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=187740, encodeId=d3d718e74061, content=涨知识,学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=43, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220115/46bcf39c32de4aa6b45c5f9d66c8ee77/6cb4a20c55bb4b7691122f47747bfca2.jpg, createdBy=9dad1662329, createdName=1ddf0692m34(暂无匿称), createdTime=Sat Apr 15 23:18:53 CST 2017, time=2017-04-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=187720, encodeId=ddb118e72078, content=继续学习。 , beContent=null, objectType=article, channel=null, level=null, likeNumber=50, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzfPkmqRTH5rHib5mcib8Wb3QdXjhfOK1UubQL2lictjJFdFJ6Lc3cnnCOSWqxXZ4Kk6y5GdzDoy764R/0, createdBy=156e1644785, createdName=doctorJiangchao, createdTime=Sat Apr 15 21:36:37 CST 2017, time=2017-04-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=187687, encodeId=a5d618e68702, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=47, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cdnapi.center.medsci.cn/medsci/head/2018/11/07/1c4abd500121276ffd9d68fbf898ae22.jpg, createdBy=4f602041120, createdName=szc1181881761, createdTime=Sat Apr 15 15:21:57 CST 2017, time=2017-04-15, status=1, ipAttribution=)]
    2017-04-15 1ddf0692m34(暂无匿称)

    涨知识,学习了

    0

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    2017-04-15 doctorJiangchao

    继续学习。

    0

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    2017-04-15 szc1181881761

    学习了

    0