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CLIN CANCER RES：溶瘤疫苗病毒GL-ONC1治疗腹膜转移癌

2018-09-19 MedSci MedSci原创

腹膜转移癌溶瘤病毒GL-ONC1
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腹膜转移癌是常见的晚期肿瘤，通常由消化道肿瘤、妇科肿瘤或原发腹膜癌进展而来。目前的治疗策略有效性均较差，需要开发新的治疗方案。CLIN CANCER RES近期发表了一篇文章，评估腹腔内注射溶瘤疫苗病毒GL-ONC1治疗晚期腹膜转移癌患者的安全性，最大耐受剂量及抗肿瘤活性。

腹膜转移癌是常见的晚期肿瘤，通常由消化道肿瘤、妇科肿瘤或原发腹膜癌进展而来。目前的治疗策略有效性均较差，需要开发新的治疗方案。CLIN CANCER RES近期发表了一篇文章，评估腹腔内注射溶瘤疫苗病毒GL-ONC1治疗晚期腹膜转移癌患者的安全性，最大耐受剂量及抗肿瘤活性。

作者根据标准3+3剂量递增设计，在三个不同剂量水平（107-109）腹腔内注射GL-ONC1，每四周一次，共四个周期。主要的研究目的为GL-ONC1的安全性。最终有7例晚期腹膜转移癌患者以及2例晚期腹膜间皮瘤患者纳入研究。不良反应局限于1-3级，包括短暂的流感样症状以及腹痛增加，其原因是治疗导致的腹膜炎。未出现剂量限制毒性，未到达最大耐受剂量。所有患者均出现针对GL-ONC1的中和反应。

文章最后认为，GL-ONC1注射入晚期腹膜转移癌患者的腹腔中耐受性良好。有效的肿瘤细胞感染，患者内病毒复制以及溶瘤反应局限于第一个周期。

原始出处：
Ulrich M.Lauer,Martina Schell,et al.Phase ⅠStudy of Oncolytic Vaccinia Virus GL-ONC1 in Patients with Peritoneal Carcinomatosis.CLIN CANCER RES.September 2018 doi:10.1158/1078-0432.CCR-18-0244

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    2018-10-19 kcb069

    #转移癌#

    0

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    2018-09-21 新生儿张玉军

    #腹膜转移#

    0

  3. [GetPortalCommentsPageByObjectIdResponse(id=2045792, encodeId=0db62045e92aa, content=<a href='/topic/show?id=f3c2934568b' target=_blank style='color:#2F92EE;'>#转移癌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=50, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=93456, encryptionId=f3c2934568b, topicName=转移癌)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=87b1109, createdName=kcb069, createdTime=Fri Oct 19 05:08:00 CST 2018, time=2018-10-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1578997, encodeId=46b215e8997eb, content=<a href='/topic/show?id=0ff4856621f' target=_blank style='color:#2F92EE;'>#腹膜转移#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=85662, encryptionId=0ff4856621f, topicName=腹膜转移)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=6e6d16475304, createdName=新生儿张玉军, createdTime=Fri Sep 21 09:08:00 CST 2018, time=2018-09-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1623804, encodeId=a5201623804f9, content=<a href='/topic/show?id=16ba8564526' target=_blank style='color:#2F92EE;'>#腹膜#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=85645, encryptionId=16ba8564526, topicName=腹膜)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=93e220615097, createdName=xuyong530, createdTime=Fri Sep 21 09:08:00 CST 2018, time=2018-09-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=345792, encodeId=e001345e9277, content=了解一下谢谢, beContent=null, objectType=article, channel=null, level=null, likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTLbTp9nZtjwVrSZNxAXbAicnKQWnic2eBdJUQYhxO36XdkstSicr7FVF8p5ReH4omtmsbnLdvZLiaJJ1A/132, createdBy=8bff2327056, createdName=kafei, createdTime=Thu Sep 20 08:54:05 CST 2018, time=2018-09-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=345727, encodeId=bf01345e27b8, content=了解一下，谢谢分享！, beContent=null, objectType=article, channel=null, level=null, likeNumber=69, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cdnapi.center.medsci.cn/medsci/head/2019/12/23/2f51002e1349ccda5be11c1eea1e1e60.jpg, createdBy=a22097948, createdName=天地飞扬, createdTime=Wed Sep 19 20:48:34 CST 2018, time=2018-09-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=345719, encodeId=fe8c345e19a1, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=69, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=82311653708, createdName=医者仁心5538, createdTime=Wed Sep 19 20:33:25 CST 2018, time=2018-09-19, status=1, ipAttribution=)]
    2018-09-21 xuyong530

    #腹膜#

    0

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    2018-09-20 kafei

    了解一下谢谢

    0

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    2018-09-19 天地飞扬

    了解一下，谢谢分享！

    0

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    2018-09-19 医者仁心5538

    学习了

    0

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