Eur Heart J:首次急性心梗后左心室栓塞患者,合理抗凝获益多

2018-03-02 吴星 环球医学

2018年1月,发表在《Eur Heart J》的一项由日本科学家进行的研究,考察了首次急性心梗(AMI)后左心室栓塞(LVT)患者抗凝联合抗血小板治疗的疗效。

2018年1月,发表在《Eur Heart J》的一项由日本科学家进行的研究,考察了首次急性心梗(AMI)后左心室栓塞(LVT)患者抗凝联合抗血小板治疗的疗效。

目的:首次AMI合并LVT患者在将出血事件最小化的同时最佳抗血栓治疗的数据有限。

方法和结果:2001~2014年2301例AMI连续住院患者中,研究者考察了1850例存活出院的首次AMI患者,旨在调查他们的临床特征、全身性栓塞(SE)发生率、抗凝和血栓或出血事件相关性。左心室栓塞通过超声心动图、左心室造影或心脏磁共振成像确诊。共有92例患者(5.0%,62±12岁)确诊。中位随访5.4年(四分位数间距,2.1~9.1年),15/92例LVT患者(16.3%)和51/1758例无LVT患者(2.9%)发生SE。Kaplan-Meier分析显示,LVT组SE发生率显著更高(对数秩检验,P<0.001)。多变量分析显示,LVT为SE的独立预测因素。接受维生素K拮抗剂治疗的LVT患者中(84例),研究者比较了治疗范围(TTR≥50%)的患者(34例)和TTR<50%的患者(50例)。仅有1例TTR≥50%的患者发生栓塞事件,而TTR<50%的患者发生9例(2.9% vs 19%;P=0.036)。大出血事件无差异(TTR≥50% vs TTR<50%:9% vs 8%;P=0.89)。

结论:首次AMI合并LV栓塞的患者中,合理的抗凝治疗可降低栓塞事件发生率而不增加出血事件发生率。

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    2018-09-01 lfyang
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    2018-03-05 大爰

    学习了谢谢分享!!

    0

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    2018-03-03 zhaojie88
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    2018-03-03 slcumt
  7. [GetPortalCommentsPageByObjectIdResponse(id=2053410, encodeId=3a912053410d5, content=<a href='/topic/show?id=93255105e89' target=_blank style='color:#2F92EE;'>#心梗后#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=51057, encryptionId=93255105e89, topicName=心梗后)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=43cb463, createdName=lfyang, createdTime=Sat Sep 01 18:39:00 CST 2018, time=2018-09-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=293187, encodeId=acae29318e52, content=学习了谢谢分享!!, beContent=null, objectType=article, channel=null, level=null, likeNumber=47, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20200816/e4675a86ea694f12b82202b320dc2654/12f6b900498349e994ce8f516a584d6a.jpg, createdBy=09431951290, createdName=大爰, createdTime=Mon Mar 05 09:09:46 CST 2018, time=2018-03-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1308366, encodeId=92251308366d2, content=<a href='/topic/show?id=8323522e503' target=_blank style='color:#2F92EE;'>#急性心梗#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=52275, encryptionId=8323522e503, topicName=急性心梗)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=fa4f352, createdName=chenlianhui, createdTime=Sat Mar 03 23:39:00 CST 2018, time=2018-03-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1356719, encodeId=a9cb1356e1999, content=<a href='/topic/show?id=b0702e84b9' target=_blank style='color:#2F92EE;'>#ART#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2784, encryptionId=b0702e84b9, topicName=ART)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=zhaojie88, createdTime=Sat Mar 03 23:39:00 CST 2018, time=2018-03-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1413218, encodeId=9e19141321879, content=<a href='/topic/show?id=1d7e48033f5' target=_blank style='color:#2F92EE;'>#左心室#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=48033, encryptionId=1d7e48033f5, topicName=左心室)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=15012955474, createdName=wushaoling, createdTime=Sat Mar 03 23:39:00 CST 2018, time=2018-03-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1562864, encodeId=ba7e156286470, content=<a href='/topic/show?id=f69d864413' target=_blank style='color:#2F92EE;'>#HEART#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=8644, encryptionId=f69d864413, topicName=HEART)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=80d715270048, createdName=slcumt, createdTime=Sat Mar 03 23:39:00 CST 2018, time=2018-03-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=292556, encodeId=c7c92925561f, content=学习.谢谢分享., beContent=null, objectType=article, channel=null, level=null, likeNumber=42, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/xkvRjYnJzzRJ2R0y7VhicibvkjPWHjIMmu4ZpKnE9cWAu4lVicS3uDUCfF4M4JWvrkrYfpb2KehPV0Ee29tPqyPEebBUibiaKhnvD/0, createdBy=f8412001184, createdName=惠映实验室, createdTime=Sat Mar 03 09:29:50 CST 2018, time=2018-03-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=292466, encodeId=fff7292466b3, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=48, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c3da1990174, createdName=yfjms, createdTime=Sat Mar 03 07:17:46 CST 2018, time=2018-03-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=292247, encodeId=bce929224e89, content=学习了.涨知识, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220115/46bcf39c32de4aa6b45c5f9d66c8ee77/6cb4a20c55bb4b7691122f47747bfca2.jpg, createdBy=9dad1662329, createdName=1ddf0692m34(暂无匿称), createdTime=Fri Mar 02 09:05:15 CST 2018, time=2018-03-02, status=1, ipAttribution=)]
    2018-03-03 惠映实验室

    学习.谢谢分享.

    0

  8. [GetPortalCommentsPageByObjectIdResponse(id=2053410, encodeId=3a912053410d5, content=<a href='/topic/show?id=93255105e89' target=_blank style='color:#2F92EE;'>#心梗后#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=51057, encryptionId=93255105e89, topicName=心梗后)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=43cb463, createdName=lfyang, createdTime=Sat Sep 01 18:39:00 CST 2018, time=2018-09-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=293187, encodeId=acae29318e52, content=学习了谢谢分享!!, beContent=null, objectType=article, channel=null, level=null, likeNumber=47, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20200816/e4675a86ea694f12b82202b320dc2654/12f6b900498349e994ce8f516a584d6a.jpg, createdBy=09431951290, createdName=大爰, createdTime=Mon Mar 05 09:09:46 CST 2018, time=2018-03-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1308366, encodeId=92251308366d2, content=<a href='/topic/show?id=8323522e503' target=_blank style='color:#2F92EE;'>#急性心梗#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=52275, encryptionId=8323522e503, topicName=急性心梗)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=fa4f352, createdName=chenlianhui, createdTime=Sat Mar 03 23:39:00 CST 2018, time=2018-03-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1356719, encodeId=a9cb1356e1999, content=<a href='/topic/show?id=b0702e84b9' target=_blank style='color:#2F92EE;'>#ART#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2784, encryptionId=b0702e84b9, topicName=ART)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=zhaojie88, createdTime=Sat Mar 03 23:39:00 CST 2018, time=2018-03-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1413218, encodeId=9e19141321879, content=<a href='/topic/show?id=1d7e48033f5' target=_blank style='color:#2F92EE;'>#左心室#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=48033, encryptionId=1d7e48033f5, topicName=左心室)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=15012955474, createdName=wushaoling, createdTime=Sat Mar 03 23:39:00 CST 2018, time=2018-03-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1562864, encodeId=ba7e156286470, content=<a href='/topic/show?id=f69d864413' target=_blank style='color:#2F92EE;'>#HEART#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=8644, encryptionId=f69d864413, topicName=HEART)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=80d715270048, createdName=slcumt, createdTime=Sat Mar 03 23:39:00 CST 2018, time=2018-03-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=292556, encodeId=c7c92925561f, content=学习.谢谢分享., beContent=null, objectType=article, channel=null, level=null, likeNumber=42, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/xkvRjYnJzzRJ2R0y7VhicibvkjPWHjIMmu4ZpKnE9cWAu4lVicS3uDUCfF4M4JWvrkrYfpb2KehPV0Ee29tPqyPEebBUibiaKhnvD/0, createdBy=f8412001184, createdName=惠映实验室, createdTime=Sat Mar 03 09:29:50 CST 2018, time=2018-03-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=292466, encodeId=fff7292466b3, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=48, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c3da1990174, createdName=yfjms, createdTime=Sat Mar 03 07:17:46 CST 2018, time=2018-03-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=292247, encodeId=bce929224e89, content=学习了.涨知识, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220115/46bcf39c32de4aa6b45c5f9d66c8ee77/6cb4a20c55bb4b7691122f47747bfca2.jpg, createdBy=9dad1662329, createdName=1ddf0692m34(暂无匿称), createdTime=Fri Mar 02 09:05:15 CST 2018, time=2018-03-02, status=1, ipAttribution=)]
    2018-03-03 yfjms

    学习

    0

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    2018-03-02 1ddf0692m34(暂无匿称)

    学习了.涨知识

    0

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Circulation:可溶性ST2作为一种新的急性主动脉夹层生物标志物的范围

对于急诊疑似主动脉夹层的患者,sST2的总体诊断性能优于D-二聚体或cTnI。

急性心梗要不要做核磁检查?浅谈心脏磁共振在急性ST段抬高型心肌梗死评价中的作用

急性ST段抬高型心肌梗死(STEMI)是导致心源性死亡的重要原因。尽管广泛应用的再灌注治疗可紧急恢复闭塞冠脉的血流,挽救部分濒死心肌并降低急性期死亡率,但存活患者仍可能因大量丢失心肌而出现心力衰竭,导致各类心血管事件