J Thromb Haemost:心房颤动与静脉血栓栓塞相互促进!

2018-02-13 xing.T MedSci原创

由此可见,AF与VTE发生增加的风险有关,VTE也与AF事件更大的风险有关。这种相关性在黑人和在诊断的最初6个月内更强,即使在6个月之后仍保持升高。这些发现有助于识别可能增加AF和VTE风险的患者人群,或许应该针对性地采取预防策略。

房颤动(AF)和静脉血栓栓塞(VTE)经常同时发生。这两种疾病具有共同的危险因素,并伴有凝血异常。此外,机制通路可能直接将这些疾病联系起来。近日,血栓和凝血疾病权威杂志Journal of Thrombosis and Haemostasis上发表了一篇研究文章,该研究旨在验证有颤患者是否发生VTE的风险更大,以及VTE患者发生房颤的风险也增高,研究人员同时检测了在最初诊断后6个月内的相关性是否更强,并探讨了是否有种族差异。

研究人员对15129名来自于ARIC研究的参与者(45-64岁,55%女性,26%黑人)从1987年-2011年期间随访至受试者发生房颤和静脉血栓栓塞事件(平均随访19.8年)。研究人员采用多变量调整的Cox回归进行分析,AF和VTE模型为时间依赖性暴露。

研究人员发现AF发生与后续高风险的VTE事件相关[(95% CI):1.71(1.32-2.22)];这种相关性在黑人 [2.30(1.48-3.58)]和AF诊断的最初6个月内[5.08(3.08-8.38)]中更强。同样, VTE发生与房颤事件的高风险相关[1.73(1.34-2.24)],尤其是黑人[ 2.40(1.55-3.74)]和VTE诊断后的最初6个月内[ 4.50(2.61-7.77)] 中更强。

由此可见,AF与VTE发生增加的风险有关,VTE也与AF事件更大的风险有关。这种相关性在黑人和在诊断的最初6个月内更强,即使在6个月之后仍保持升高。这些发现有助于识别可能增加AF和VTE风险的患者人群,或许应该针对性地采取预防策略。

原始出处:


P. L. Lutsey,et al. Atrial fibrillation and venous thromboembolism: evidence of bidirectionality in the Atherosclerosis Risk in Communities Study.Journal of Thrombosis and Haemostasis.2018. http://onlinelibrary.wiley.com/doi/10.1111/jth.13974/full

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    2018-05-12 changfy
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    2018-08-18 xue8602
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    2018-08-30 fusion
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    2018-02-16 1e0f8808m18(暂无匿称)

    好文章.学习了.

    0

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    2018-02-15 sodoo
  6. [GetPortalCommentsPageByObjectIdResponse(id=2008343, encodeId=95a320083430c, content=<a href='/topic/show?id=1066844469' target=_blank style='color:#2F92EE;'>#HAE#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=8444, encryptionId=1066844469, topicName=HAE)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=32d177, createdName=changfy, createdTime=Sat May 12 08:50:00 CST 2018, time=2018-05-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1955346, encodeId=1a561955346e0, content=<a href='/topic/show?id=0aeb991e44c' target=_blank style='color:#2F92EE;'>#静脉血#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=99174, encryptionId=0aeb991e44c, topicName=静脉血)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d139492, createdName=xue8602, createdTime=Sat Aug 18 02:50:00 CST 2018, time=2018-08-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1697644, encodeId=0ba6169e6445a, content=<a href='/topic/show?id=f2399910109' target=_blank style='color:#2F92EE;'>#静脉#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=99101, encryptionId=f2399910109, topicName=静脉)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=0bc129907796, createdName=fusion, createdTime=Thu Aug 30 05:50:00 CST 2018, time=2018-08-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=288284, encodeId=3a4c2882847f, content=好文章.学习了., beContent=null, objectType=article, channel=null, level=null, likeNumber=50, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=60791943465, createdName=1e0f8808m18(暂无匿称), createdTime=Fri Feb 16 01:32:53 CST 2018, time=2018-02-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1626866, encodeId=eef01626866dc, content=<a href='/topic/show?id=986a5101e46' target=_blank style='color:#2F92EE;'>#心房#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=51017, encryptionId=986a5101e46, topicName=心房)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=20ba21064884, createdName=sodoo, createdTime=Thu Feb 15 07:50:00 CST 2018, time=2018-02-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=288056, encodeId=46b6288056d8, content=学习了.谢谢分享., beContent=null, objectType=article, channel=null, level=null, likeNumber=50, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=60791943465, createdName=1e0f8808m18(暂无匿称), createdTime=Thu Feb 15 06:16:40 CST 2018, time=2018-02-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=288005, encodeId=ce7a2880050c, content=学习.谢谢分享., beContent=null, objectType=article, channel=null, level=null, likeNumber=56, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/xkvRjYnJzzRJ2R0y7VhicibvkjPWHjIMmu4ZpKnE9cWAu4lVicS3uDUCfF4M4JWvrkrYfpb2KehPV0Ee29tPqyPEebBUibiaKhnvD/0, createdBy=f8412001184, createdName=惠映实验室, createdTime=Thu Feb 15 00:00:09 CST 2018, time=2018-02-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=287766, encodeId=5de028e7664b, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=47, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NfBfgWn9nXBgH1sNSiaOAKhsKpN40jDHQKqcRzovau5VibLvREN8uxnu9sKoScBicHSiaDMmbveibFdrBiaD4k4IOPwlG/0, createdBy=b5d11730951, createdName=Jackie Li, createdTime=Wed Feb 14 05:04:16 CST 2018, time=2018-02-14, status=1, ipAttribution=)]
    2018-02-15 1e0f8808m18(暂无匿称)

    学习了.谢谢分享.

    0

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    2018-02-15 惠映实验室

    学习.谢谢分享.

    0

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    2018-02-14 Jackie Li

    学习

    0

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