Diabetologia : 超重和肥胖的糖尿病母亲可增加后代新生儿窒息相关并发症的危险性

2017-04-16 MedSci MedSci原创

尽管对1型或2型糖尿病孕妇的管理在不断进步,但新生儿发病率和死亡率的风险仍然在增加。

在1型糖尿病母亲的后代中,常出现较低阿氏评分且可显著增加新生儿发病率和死亡率的危险性。但是,较低阿氏评分或其他新生儿窒息相关并发症在2型糖尿病母亲的后代中是否也增多,尚不明确。

近日,糖尿病领域权威杂志Diabetologia上发表了一项研究,研究人员旨在比较1型和2型糖尿病母亲后代中发生严重新生儿窒息相关并发症的危险性,并评估母亲超重或肥胖对此危险性的影响。

该研究的人群来自瑞典1997年至2011年间出生的1,343,751例单胎活婴。本研究分别纳入了5941例母亲患有1型糖尿病的婴儿和711例母亲患有2型糖尿病的婴儿。研究人员计算了出生后5分钟较低的阿氏评分(0-6)、缺氧缺血性脑病和新生儿癫痫的95%置信区间的比值比。

此项研究结果显示:母亲无糖尿病、患有1型糖尿病和患有2型糖尿病,其后代出现较低阿氏评分的发生率分别是0.9%, 2.6% 和 2.1%。校正母亲的混杂因素(包括BMI)后,母亲患有1型糖尿病的后代的较低阿氏评分的危险性显著增加(OR 2.67, 95% CI 2.23, 3.20),而母亲患有2型糖尿病的后代的较低阿氏评分的危险性并无显著增加(OR 1.25, 95% CI 0.66, 2.35)。此外,在母亲无糖尿病和患有1型糖尿病的人群中,母亲超重或肥胖是后代中出现新生儿窒息相关并发症和较低阿氏评分的一个危险因素。
 
综上,该研究表明:母亲患有1型或2型糖尿病,其后代出现较低阿氏评分和严重新生儿窒息相关并发症的危险性是增加的。母亲超重或肥胖是一个重要的影响因素。

原始出处:

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    2017-07-22 丁鹏鹏
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    2017-04-18 绛珠草小姐

    学习了,谢谢分享

    0

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    2017-04-17 qjzhai1623

    肥胖要重视

    0

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