小儿肾病综合征合并多发真菌性脑脓肿1例

2018-02-05 佚名 中华神经外科疾病研究杂志

患者,女性,10岁

【一般资料】

患者,女性,10岁

【主诉】

因头痛2月,加重伴恶心、呕吐3天于2015年11月24日入院。

【现病史】

入院前11个月确诊为“肾病综合征”,口服强的松2mg/kg·d,每4周减量0.5mg/kg·d。

【体格检查】

一般状态可,神志清楚,无颜面、肢体水肿,双侧瞳孔等大正圆,直径约3.0mm,直接、间接对光反射均灵敏,四肢肌力V级,肌张力正常,深浅感觉未见异常,无颈强直。

【辅助检查】

头颅增强MRI示颅内多发环形病灶伴左侧额叶大片水肿及囊变,结合长期激素服用病史,左额叶真菌性脑脓肿待排(图1)。



【初步诊断

左额叶占位(脓肿可能性大)。

【治疗】

病情显示,患者有高颅压表现,MRI显示病灶及水肿有明显占位效应。于2015年11月27日在全麻下行左额叶占位切除术。手术采用左额入路,马蹄状切口,术中所见病灶壁厚、韧,液波感明显,穿刺抽吸见有黄绿色浑浊脓液,较稀薄。病灶为三房性,两房较大,一房较小。予以完全切除。术后脓液涂片示:烟曲霉菌;囊壁行病理检查示:多核巨细胞和吞噬细胞浸润,嗜银染色可见大量霉菌孢子和菌丝(图2)。病理诊断为(左额叶)脑脓肿伴真菌感染及坏死、肉芽组织形成。最终诊断:左额叶脑脓肿,患者术后症状明显改善,术后第8天复查头CT示脓肿消失,中线居中,术后2个月随访病情平稳,无特殊不适症状。


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    2018-02-07 zhaojie88
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    2018-02-07 qjddjq
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    2018-02-07 hunizi009
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    2018-02-05 131****1460

    学习了受益匪浅

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