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SCI REP：亚临床甲状腺功能减退患者心血管风险的无创标记！

2018-03-16 xing.T MedSci原创

亚临床甲状腺功能减退心血管风险无创标记
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由此可见，该荟萃分析证实了SCH和心血管风险与动脉壁增厚、硬化和内皮功能障碍有显著的相关性。这些发现将有助于为SCH患者制定详细的心血管预防策略。

据报道，亚临床甲状腺功能减退症与亚临床动脉粥样硬化密切相关。近日，Scientific reports杂志上发表了一篇研究文章，根据SCH对心血管危险性无创标志物的影响，研究人员完成了对纳入研究的荟萃分析，以提供全面的综述。

研究人员检索了电子数据库，纳入了所有涉及SCH和心外膜脂肪组织（EAT）、颈动脉内膜中层厚度（CIMT）、脉搏波传导速度（PWV）、血流介导的血管扩张（FMD）和硝酸甘油诱导的扩张（GNT诱导的扩张）的相关研究。在meta分析中计算结果来评估SCH对这些标记的影响。

在最后的分析中，总共进行了27项研究。与正常对照相比，SCH患者表现出显著增加的CIMT（SMD：0.369mm；95%可信区间：0.038-0.700；P=0.029）和EAT（SMD：1.167mm；95%可信区间：0.869-1.466；P=0.0）和增加的PWV（SMD：3.574m/s；95%可信区间：0.935-6.213，P=0.008）。研究人员还发现了显著降低的FMD（SMD：−1.525%，95%可信区间：−2.156至−0.894，P = 0.0）和较低的GNT诱导扩张（SMD：−0.384%，95%可信区间：−0.625至−0.142，P = 0.002）。敏感性分析和亚组分析证实了上述结果。

由此可见，该荟萃分析证实了SCH和心血管风险与动脉壁增厚、硬化和内皮功能障碍有显著的相关性。这些发现将有助于为SCH患者制定详细的心血管预防策略。

原始出处：

Kecheng Yao,et al. Non-invasive markers of cardiovascular risk in patients with subclinical hypothyroidism: A systematic review and meta-analysis of 27 case control studies.Scientific reports.2018. https://www.nature.com/articles/s41598-018-22897-3

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    2018-04-23 zhangmingxiang

    #临床甲状腺功能减退#

    0

  2. 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    2018-04-11 ms5353107019656438

    #血管风险#

    0

  3. 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    2018-03-16 虈亣靌

    好文.值得点赞!认真学习了.把经验应用于实践.为患者解除病痛.

    0

  4. 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    2018-03-16 139****5926

    好好文章学习了

    0

  5. [GetPortalCommentsPageByObjectIdResponse(id=1797432, encodeId=9b6e1e97432aa, content=<a href='/topic/show?id=b84c22894e2' target=_blank style='color:#2F92EE;'>#临床甲状腺功能减退#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=22894, encryptionId=b84c22894e2, topicName=临床甲状腺功能减退)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c6fc262, createdName=zhangmingxiang, createdTime=Mon Apr 23 07:50:00 CST 2018, time=2018-04-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2082454, encodeId=17ad2082454fb, content=<a href='/topic/show?id=56658981223' target=_blank style='color:#2F92EE;'>#血管风险#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=17, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=89812, encryptionId=56658981223, topicName=血管风险)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdqq.qlogo.cn/qqapp/101296147/78FA0899509C358B01B975E8EAC1F88A/100, createdBy=7d822500145, createdName=ms5353107019656438, createdTime=Wed Apr 11 00:50:00 CST 2018, time=2018-04-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=296849, encodeId=fe3729684973, content=好文.值得点赞!认真学习了.把经验应用于实践.为患者解除病痛., beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zMoyicyo6ia9f4IuLQAwZoxD6Hx4ibd5CMcOCYhStY6oDibbKK6O2X8iaicldO5ib8j1iapOIobIKCGiczU2A/0, createdBy=56251941490, createdName=虈亣靌, createdTime=Fri Mar 16 18:14:38 CST 2018, time=2018-03-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=296750, encodeId=88bf296e5018, content=好好文章学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib06iaV3D9Tg5K1RUfOKQohib4bXhDtxVgOA9VcKY1LUZkCOmr0v3WupxANz2ibibNHkdevtSruvrhyI29IjXdtvUV48/0, createdBy=6ff82057534, createdName=139****5926, createdTime=Fri Mar 16 10:00:14 CST 2018, time=2018-03-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=296749, encodeId=281e296e492a, content=学习了谢谢了, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zSn0GqHrsfLPeNmuNF9ibgMfMOAs7Iic5MpiaU8RLmRH67xCKuk5wzfhb7G4ib7ia6z9lrnsTicj1nAUfEOMecZDtvvu/0, createdBy=d7f91939785, createdName=186****0580(小山羊）, createdTime=Fri Mar 16 09:43:11 CST 2018, time=2018-03-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=296747, encodeId=b4ad296e4715, content=学习了.获益匪浅.感谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2018/02/27/c53a212859edcad4f60a54feffff50bb.jpg, createdBy=67cf1525321, createdName=13718711b3m, createdTime=Fri Mar 16 09:35:24 CST 2018, time=2018-03-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=296740, encodeId=1d88296e40e2, content=优质资源.共同学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib06iaV3D9Tg5K0LqDY57Aia0TOQByoJhNt3icm4sfukp500hLH6RHOpFdV01NbECtAV7s0qKpQPibyRukQAwAmqJU3X/0, createdBy=f91f1928792, createdName=九九消寒, createdTime=Fri Mar 16 09:09:05 CST 2018, time=2018-03-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=296733, encodeId=1fbc296e332f, content=学习谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=10, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4Nd44v3xHnnictn9UpctwtH62EPQ59TMdI9lnqHMgQ16nH7GmGCfpzicsHgjibYVk6vwSpXrC86gMibRkoaIzf5HwSz7/0, createdBy=78cc1691107, createdName=龙胆草, createdTime=Fri Mar 16 08:45:27 CST 2018, time=2018-03-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=296726, encodeId=b93e296e26b8, content=学习了.长知识, beContent=null, objectType=article, channel=null, level=null, likeNumber=12, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220115/46bcf39c32de4aa6b45c5f9d66c8ee77/6cb4a20c55bb4b7691122f47747bfca2.jpg, createdBy=9dad1662329, createdName=1ddf0692m34(暂无匿称), createdTime=Fri Mar 16 08:24:46 CST 2018, time=2018-03-16, status=1, ipAttribution=)]
    2018-03-16 186****0580(小山羊）

    学习了谢谢了

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=1797432, encodeId=9b6e1e97432aa, content=<a href='/topic/show?id=b84c22894e2' target=_blank style='color:#2F92EE;'>#临床甲状腺功能减退#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=22894, encryptionId=b84c22894e2, topicName=临床甲状腺功能减退)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c6fc262, createdName=zhangmingxiang, createdTime=Mon Apr 23 07:50:00 CST 2018, time=2018-04-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2082454, encodeId=17ad2082454fb, content=<a href='/topic/show?id=56658981223' target=_blank style='color:#2F92EE;'>#血管风险#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=17, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=89812, encryptionId=56658981223, topicName=血管风险)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdqq.qlogo.cn/qqapp/101296147/78FA0899509C358B01B975E8EAC1F88A/100, createdBy=7d822500145, createdName=ms5353107019656438, createdTime=Wed Apr 11 00:50:00 CST 2018, time=2018-04-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=296849, encodeId=fe3729684973, content=好文.值得点赞!认真学习了.把经验应用于实践.为患者解除病痛., beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zMoyicyo6ia9f4IuLQAwZoxD6Hx4ibd5CMcOCYhStY6oDibbKK6O2X8iaicldO5ib8j1iapOIobIKCGiczU2A/0, createdBy=56251941490, createdName=虈亣靌, createdTime=Fri Mar 16 18:14:38 CST 2018, time=2018-03-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=296750, encodeId=88bf296e5018, content=好好文章学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib06iaV3D9Tg5K1RUfOKQohib4bXhDtxVgOA9VcKY1LUZkCOmr0v3WupxANz2ibibNHkdevtSruvrhyI29IjXdtvUV48/0, createdBy=6ff82057534, createdName=139****5926, createdTime=Fri Mar 16 10:00:14 CST 2018, time=2018-03-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=296749, encodeId=281e296e492a, content=学习了谢谢了, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zSn0GqHrsfLPeNmuNF9ibgMfMOAs7Iic5MpiaU8RLmRH67xCKuk5wzfhb7G4ib7ia6z9lrnsTicj1nAUfEOMecZDtvvu/0, createdBy=d7f91939785, createdName=186****0580(小山羊）, createdTime=Fri Mar 16 09:43:11 CST 2018, time=2018-03-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=296747, encodeId=b4ad296e4715, content=学习了.获益匪浅.感谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2018/02/27/c53a212859edcad4f60a54feffff50bb.jpg, createdBy=67cf1525321, createdName=13718711b3m, createdTime=Fri Mar 16 09:35:24 CST 2018, time=2018-03-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=296740, encodeId=1d88296e40e2, content=优质资源.共同学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib06iaV3D9Tg5K0LqDY57Aia0TOQByoJhNt3icm4sfukp500hLH6RHOpFdV01NbECtAV7s0qKpQPibyRukQAwAmqJU3X/0, createdBy=f91f1928792, createdName=九九消寒, createdTime=Fri Mar 16 09:09:05 CST 2018, time=2018-03-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=296733, encodeId=1fbc296e332f, content=学习谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=10, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4Nd44v3xHnnictn9UpctwtH62EPQ59TMdI9lnqHMgQ16nH7GmGCfpzicsHgjibYVk6vwSpXrC86gMibRkoaIzf5HwSz7/0, createdBy=78cc1691107, createdName=龙胆草, createdTime=Fri Mar 16 08:45:27 CST 2018, time=2018-03-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=296726, encodeId=b93e296e26b8, content=学习了.长知识, beContent=null, objectType=article, channel=null, level=null, likeNumber=12, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220115/46bcf39c32de4aa6b45c5f9d66c8ee77/6cb4a20c55bb4b7691122f47747bfca2.jpg, createdBy=9dad1662329, createdName=1ddf0692m34(暂无匿称), createdTime=Fri Mar 16 08:24:46 CST 2018, time=2018-03-16, status=1, ipAttribution=)]
    2018-03-16 13718711b3m

    学习了.获益匪浅.感谢分享

    0

  7. 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    2018-03-16 九九消寒

    优质资源.共同学习

    0

  8. 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    2018-03-16 龙胆草

    学习谢谢分享

    0

  9. 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    2018-03-16 1ddf0692m34(暂无匿称)

    学习了.长知识

    0

相关资讯

重复：N Engl J Med：左旋甲状腺素对亚临床甲减老年患者或是无用的治疗

亚临床甲状腺功能减退患者是否应接受左旋甲状腺激素治疗仍存在争议。2017年6月，发表在《N Engl J Med》上的一项研究显示，左旋甲状腺素未给亚临床甲状腺功能减退老年患者提供明显益处。

总结: 亚临床甲状腺功能减退的危害及治疗

作者：第四军医大学西京医院  姬秋和  蔡靖 目前，关于亚临床甲状腺功能减退（SCH），国内外已出台多部指南，如2013年欧洲甲状腺学会（ETA）《成人亚临床甲状腺功能减退指南》、2014年ETA《妊娠与儿童亚临床甲状腺功能减退指南》、2012年中华医学会内分泌学分会和围产医学分会《妊娠和产后甲状腺疾病诊治指南》及2011年美国甲状腺学会《妊娠和产后甲状

Circulation：亚临床甲状腺功能减退与心房颤动风险之间相关性分析！

由此可见，在甲状腺功能正常的个体中，较高的循环FT4水平，而不是TSH水平，与增加的AF发生风险相关。