JAHA:房颤患者的心肌灌注水平和心功能下降

2018-08-06 MedSci MedSci原创

房颤(AF)与心梗的发生相关,AF患者即使没有梗阻性冠心病也会表现出心肌缺血的症状。本研究猜测冠脉微循环功能障碍是导致这种现象的原因。本研究纳入了49例房颤患者(25例阵发性,24例永久性),并对其心肌血流(MBF)及左房左室功能进行了评估,评估的时间点为基线水平、房颤消融术后6个月和9个月,并与匹配的25例窦性心律正常对照进行比较分析。消融术前,房颤患者的左房功能、左室射血分数和应变指数均较低(

房颤(AF)与心梗的发生相关,AF患者即使没有梗阻性冠心病也会表现出心肌缺血的症状。本研究猜测冠脉微循环功能障碍是导致这种现象的原因。

本研究纳入了49例房颤患者(25例阵发性,24例永久性),并对其心肌血流(MBF)及左房左室功能进行了评估,评估的时间点为基线水平、房颤消融术后6个月和9个月,并与匹配的25例窦性心律正常对照进行比较分析。消融术前,房颤患者的左房功能、左室射血分数和应变指数均较低(p<0.05),与对照相比,房颤患者的MBF无论在基线水平还是在腺苷酸压力下均更低,在基线水平时,MBF与左室应变力和左房功能相关(P≤0.001),所以MBF最低的患者左心功能损伤最重。消融术后,患者的MBF无明显变化。

本研究结果显示,在无冠心病的房颤患者中,心肌血流明显降低,即使在消融术后,MBF的降低水平与患者左心功能不全的严重程度呈相关性。

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    2018-08-08 zhaohui6731
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