Diabetologia:超重/肥胖和正常体重的2型糖尿病患者的大脑变化

2017-06-21 MedSci MedSci原创

超重和肥胖可能会显著恶化2型糖尿病的血糖和代谢控制。然而,对超重和肥胖对2型糖尿病患者的大脑的影响了解甚少。近日,国际杂志 《Diabetologia》上在线发表一项关于早期2型糖尿病期间超重或肥胖的存在是否影响的大脑和认知功能的研究。

超重和肥胖可能会显著恶化2糖尿病的血糖和代谢控制。然而,对超重和肥胖对2糖尿病患者的大脑的影响了解甚少。近日,国际杂志 《Diabetologia》上在线发表一项关于早期2糖尿病期间超重或肥胖的存在是否影响的大脑和认知功能的研究。

研究人员调查了早期血清脂肪酸组成与1型糖尿病相关性自身免疫风险的关系。 假设是婴儿期的脂肪酸状态与1型糖尿病相关的自身免疫相关,特别是长链n-3脂肪酸与风险降低有关。

这项研究试图解开超重/肥胖对2型糖尿病患者脑结构和认知的影响。 与正常体重的参与者相比,在早期2型糖尿病期间超重/肥胖的2型糖尿病的参与者大脑结构和认知具有更严重和进行性异常。 还研究了这些措施和疾病持续时间之间的关系。

超重/肥胖2型糖尿病组的全身平均皮质厚度低于正常体重2型糖尿病组(z = -2.96,组效应p = 0.003)。在超重/肥胖2型糖尿病组中,在病程和全身平均白质完整性(z = 2.42p为相互作用= 0.02)之间观察到负相关,在正常体重2型糖尿病组中却没有。 超重/肥胖的2型糖尿病患者与疾病持续时间相关的精神运动速度表现减少(z = -2.12p相互作用= 0.03),而正常体重参与者没有。

目前的研究试图解开超重/肥胖对2型糖尿病患者脑结构和认知的影响。与正常体重参与者相比,超重/肥胖的2型糖尿病的参与者在2型糖尿病早期脑结构和认知中具有更为严重的和进行性的异常。

原始出处:

Sujung Yoon, Hanbyul Cho, Jungyoon Kim, Do-Wan Lee,et al. Brain changes in overweight/obese and normal-weight adults with type 2 diabetes mellitus.

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    2017-06-22 135****7952平儿

    学习。。。。。。。。。

    0

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    2017-06-22 Y—xianghai

    学习了新知识

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    2017-06-22 半夏微凉

    学习了谢谢分享

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    2017-06-22 184****9840

    学习了谢谢分享。

    0

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