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EUR J Cancer：曲氟尿苷复方治疗转移性结直肠癌的III临床试验中的更佳亚组

2018-02-27 MedSci MedSci原创

曲氟尿苷转移性结直肠癌KRAS
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在III期临床试验（RECOURSE）中，曲氟尿苷复方（TAS-102）延长了转移性结直肠癌患者的总生存期（OS）和无进展生存期（PFS），这些患者均不耐受标准治疗。 本研究分析了TROURSE亚组中曲氟尿苷复方的有效性和安全性。

EUR J Cancer：曲氟尿苷复方治疗转移性结直肠癌的III临床试验中的最佳亚组

在III期临床试验（RECOURSE）中，曲氟尿苷复方（TAS-102）延长了转移性结直肠癌患者的总生存期（OS）和无进展生存期（PFS），这些患者均不耐受标准治疗。 本研究分析了TROURSE亚组中曲氟尿苷复方的有效性和安全性。

在TROURSE亚组中，使用Cox比例风险模型来评估次要和主要临床终点，并评价KRAS状态。共有800名患者入组（美国，n = 99；欧盟，n = 403；日本，n = 266）。最终的OS分析证实了与曲氟尿苷复方相关的生存获益，风险比（HR）为0.69（95%置信区间[CI] 0.59-0.81；P = 0.0001）。在曲氟尿苷复方组中，三个地区的中位OS为6.5-7.8个月，安慰剂组为4.3-6.7个月（美国：HR 0.56；95%CI 0.34-0.94；P = 0.0277；欧盟：HR 0.62；95%CI 0.48-0.80；P = 0.0002；日本：HR 0.75；95%CI 0.57-1.00；P = 0.0470）。 曲氟尿苷复方的中位PFS为2.0-2.8个月，安慰剂为1.7-1.8个月；HR在所有地区都倾向于曲氟尿苷复方。在老年患者和具有突变KRAS肿瘤的患者中观察到类似的临床获益。

因此曲氟尿苷复方在所有亚组中均有效，且无论年龄、地理来源或KRAS状态如何。

 

原始出处：

Van Cutsem, Eric, et al. "The subgroups of the phase III RECOURSE trial of trifluridine/tipiracil (TAS-102) versus placebo with best supportive care in patients with metastatic colorectal cancer." European Journal of Cancer 2018 90: 63-72. doi.org/10.1016/j.ejca.

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    2018-09-06 juliusluan78

    #III#

    0

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    2018-04-15 1e145228m78(暂无匿称)

    学习了.谢谢作者分享!

    0

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createdName=1249842em09(暂无昵称), createdTime=Thu Mar 01 13:10:00 CST 2018, time=2018-03-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1453091, encodeId=3a2e14530913b, content=<a href='/topic/show?id=098ee8679ad' target=_blank style='color:#2F92EE;'>#结直肠#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=78679, encryptionId=098ee8679ad, topicName=结直肠)], attachment=null, authenticateStatus=null, createdAvatar=/v1.0.0/img/user_icon.png, createdBy=9ace5575596, createdName=crystal0564, createdTime=Thu Mar 01 13:10:00 CST 2018, time=2018-03-01, status=1, ipAttribution=)]
    2018-04-10 1e145228m78(暂无匿称)

    学习了.谢谢作者分享!

    0

  4. 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createdName=1249842em09(暂无昵称), createdTime=Thu Mar 01 13:10:00 CST 2018, time=2018-03-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1453091, encodeId=3a2e14530913b, content=<a href='/topic/show?id=098ee8679ad' target=_blank style='color:#2F92EE;'>#结直肠#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=78679, encryptionId=098ee8679ad, topicName=结直肠)], attachment=null, authenticateStatus=null, createdAvatar=/v1.0.0/img/user_icon.png, createdBy=9ace5575596, createdName=crystal0564, createdTime=Thu Mar 01 13:10:00 CST 2018, time=2018-03-01, status=1, ipAttribution=)]
    2018-04-09 1e145228m78(暂无匿称)

    学习了.谢谢作者分享!

    0

  5. 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createdName=1249842em09(暂无昵称), createdTime=Thu Mar 01 13:10:00 CST 2018, time=2018-03-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1453091, encodeId=3a2e14530913b, content=<a href='/topic/show?id=098ee8679ad' target=_blank style='color:#2F92EE;'>#结直肠#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=78679, encryptionId=098ee8679ad, topicName=结直肠)], attachment=null, authenticateStatus=null, createdAvatar=/v1.0.0/img/user_icon.png, createdBy=9ace5575596, createdName=crystal0564, createdTime=Thu Mar 01 13:10:00 CST 2018, time=2018-03-01, status=1, ipAttribution=)]
    2018-03-29 1e145228m78(暂无匿称)

    学习了.谢谢作者分享!学习了.谢谢作者分享!

    0

  6. 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createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3xJXLtMtt5B40XXuPjn9xn1rBhrM6fHLkX1hI86ZoWoPJkgDkZuJNKkBfBHOcRd1fAdezg7JlHNOokohdAp3WkI/0, createdBy=32c81964262, createdName=1e145228m78(暂无匿称), createdTime=Mon Apr 09 20:38:57 CST 2018, time=2018-04-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=300916, encodeId=c66c300916aa, content=学习了.谢谢作者分享!学习了.谢谢作者分享!, beContent=null, objectType=article, channel=null, level=null, likeNumber=54, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3xJXLtMtt5B40XXuPjn9xn1rBhrM6fHLkX1hI86ZoWoPJkgDkZuJNKkBfBHOcRd1fAdezg7JlHNOokohdAp3WkI/0, createdBy=32c81964262, createdName=1e145228m78(暂无匿称), createdTime=Thu Mar 29 20:16:57 CST 2018, time=2018-03-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=300052, encodeId=25a8300052d0, content=学习了.谢谢作者分享!, beContent=null, objectType=article, channel=null, level=null, likeNumber=51, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3xJXLtMtt5B40XXuPjn9xn1rBhrM6fHLkX1hI86ZoWoPJkgDkZuJNKkBfBHOcRd1fAdezg7JlHNOokohdAp3WkI/0, createdBy=32c81964262, createdName=1e145228m78(暂无匿称), createdTime=Tue Mar 27 06:05:25 CST 2018, time=2018-03-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=299866, encodeId=ee0b299866a7, content=学习了.谢谢作者分享!, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3xJXLtMtt5B40XXuPjn9xn1rBhrM6fHLkX1hI86ZoWoPJkgDkZuJNKkBfBHOcRd1fAdezg7JlHNOokohdAp3WkI/0, createdBy=32c81964262, createdName=1e145228m78(暂无匿称), createdTime=Mon Mar 26 11:48:08 CST 2018, time=2018-03-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=299615, encodeId=177729961583, content=学习了.谢谢作者分享!, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3xJXLtMtt5B40XXuPjn9xn1rBhrM6fHLkX1hI86ZoWoPJkgDkZuJNKkBfBHOcRd1fAdezg7JlHNOokohdAp3WkI/0, createdBy=32c81964262, createdName=1e145228m78(暂无匿称), createdTime=Sun Mar 25 20:12:07 CST 2018, time=2018-03-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1386367, encodeId=a18e138636e36, content=<a href='/topic/show?id=f08293399f9' target=_blank style='color:#2F92EE;'>#转移性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=93399, encryptionId=f08293399f9, topicName=转移性)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1ac22500003, createdName=1249842em09(暂无昵称), createdTime=Thu Mar 01 13:10:00 CST 2018, time=2018-03-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1453091, encodeId=3a2e14530913b, content=<a href='/topic/show?id=098ee8679ad' target=_blank style='color:#2F92EE;'>#结直肠#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=78679, encryptionId=098ee8679ad, topicName=结直肠)], attachment=null, authenticateStatus=null, createdAvatar=/v1.0.0/img/user_icon.png, createdBy=9ace5575596, createdName=crystal0564, createdTime=Thu Mar 01 13:10:00 CST 2018, time=2018-03-01, status=1, ipAttribution=)]
    2018-03-27 1e145228m78(暂无匿称)

    学习了.谢谢作者分享!

    0

  7. 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createdName=1249842em09(暂无昵称), createdTime=Thu Mar 01 13:10:00 CST 2018, time=2018-03-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1453091, encodeId=3a2e14530913b, content=<a href='/topic/show?id=098ee8679ad' target=_blank style='color:#2F92EE;'>#结直肠#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=78679, encryptionId=098ee8679ad, topicName=结直肠)], attachment=null, authenticateStatus=null, createdAvatar=/v1.0.0/img/user_icon.png, createdBy=9ace5575596, createdName=crystal0564, createdTime=Thu Mar 01 13:10:00 CST 2018, time=2018-03-01, status=1, ipAttribution=)]
    2018-03-26 1e145228m78(暂无匿称)

    学习了.谢谢作者分享!

    0

  8. 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createdName=1249842em09(暂无昵称), createdTime=Thu Mar 01 13:10:00 CST 2018, time=2018-03-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1453091, encodeId=3a2e14530913b, content=<a href='/topic/show?id=098ee8679ad' target=_blank style='color:#2F92EE;'>#结直肠#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=78679, encryptionId=098ee8679ad, topicName=结直肠)], attachment=null, authenticateStatus=null, createdAvatar=/v1.0.0/img/user_icon.png, createdBy=9ace5575596, createdName=crystal0564, createdTime=Thu Mar 01 13:10:00 CST 2018, time=2018-03-01, status=1, ipAttribution=)]
    2018-03-25 1e145228m78(暂无匿称)

    学习了.谢谢作者分享!

    0

  9. 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createdName=1249842em09(暂无昵称), createdTime=Thu Mar 01 13:10:00 CST 2018, time=2018-03-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1453091, encodeId=3a2e14530913b, content=<a href='/topic/show?id=098ee8679ad' target=_blank style='color:#2F92EE;'>#结直肠#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=78679, encryptionId=098ee8679ad, topicName=结直肠)], attachment=null, authenticateStatus=null, createdAvatar=/v1.0.0/img/user_icon.png, createdBy=9ace5575596, createdName=crystal0564, createdTime=Thu Mar 01 13:10:00 CST 2018, time=2018-03-01, status=1, ipAttribution=)]
    2018-03-01 1249842em09(暂无昵称)

    #转移性#

    0

  10. 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createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3xJXLtMtt5B40XXuPjn9xn1rBhrM6fHLkX1hI86ZoWoPJkgDkZuJNKkBfBHOcRd1fAdezg7JlHNOokohdAp3WkI/0, createdBy=32c81964262, createdName=1e145228m78(暂无匿称), createdTime=Mon Apr 09 20:38:57 CST 2018, time=2018-04-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=300916, encodeId=c66c300916aa, content=学习了.谢谢作者分享!学习了.谢谢作者分享!, beContent=null, objectType=article, channel=null, level=null, likeNumber=54, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3xJXLtMtt5B40XXuPjn9xn1rBhrM6fHLkX1hI86ZoWoPJkgDkZuJNKkBfBHOcRd1fAdezg7JlHNOokohdAp3WkI/0, createdBy=32c81964262, createdName=1e145228m78(暂无匿称), createdTime=Thu Mar 29 20:16:57 CST 2018, time=2018-03-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=300052, encodeId=25a8300052d0, content=学习了.谢谢作者分享!, beContent=null, objectType=article, channel=null, 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createdName=1249842em09(暂无昵称), createdTime=Thu Mar 01 13:10:00 CST 2018, time=2018-03-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1453091, encodeId=3a2e14530913b, content=<a href='/topic/show?id=098ee8679ad' target=_blank style='color:#2F92EE;'>#结直肠#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=78679, encryptionId=098ee8679ad, topicName=结直肠)], attachment=null, authenticateStatus=null, createdAvatar=/v1.0.0/img/user_icon.png, createdBy=9ace5575596, createdName=crystal0564, createdTime=Thu Mar 01 13:10:00 CST 2018, time=2018-03-01, status=1, ipAttribution=)]
    2018-03-01 crystal0564

    #结直肠#

    0

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