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JACC：PSCK9可作为房颤患者心血管不良事件发生的预测因子

2017-09-17 MedSci MedSci原创

心血管房颤PSCK9
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既往研究证实可溶性蛋白转化酶枯草溶菌素9（PCSK9）可作为高风险心血管疾病患者的心血管事件（CVEs）发生的预测因子，然而，对于房颤患者，PCSK9的预测效果如何尚未阐明。本研究纳入了907名接受维生素K抗凝治疗的房颤患者，对其CVEs进行评估，包括致死性或非致死性心梗、缺血性卒中和心源性死亡。入院时，对患者的PCSK9和血小板激活的标志物-尿11脱氢血栓素B2（(11-dh-TxB2）水平进行

既往研究证实可溶性蛋白转化酶枯草溶菌素9（PCSK9）可作为高风险心血管疾病患者的心血管事件（CVEs）发生的预测因子，然而，对于房颤患者，PCSK9的预测效果如何尚未阐明。

本研究纳入了907名接受维生素K抗凝治疗的房颤患者，对其CVEs进行评估，包括致死性或非致死性心梗、缺血性卒中和心源性死亡。入院时，对患者的PCSK9和血小板激活的标志物-尿11脱氢血栓素B2（(11-dh-TxB2）水平进行测量。纳入研究对象患者的平均年龄为73.5 ± 8.2岁，女性占43%。随访期间，共有179个CVEs发生，三组不同PCSK9水平的患者的CVEs各为43 (15.3%)、 49 (15.5%)和 87 (28.0%)。出现有CVEs患者的PCSK9的水平明显要高于没有CVEs的患者（p<0.001）。多元回归分析结果表明，高水平的PSCK9（HR：1.640； 95% Cl： 1.117 - 2.407； p = 0.012）、女性、年龄、糖尿病、抽烟、心衰、心脑血管疾病史、地高辛的使用和总胆固醇与高密度脂蛋白胆固醇比值均与CVEs呈相关性。

研究结果表明，血浆PCSK9的水平可作为房颤患者心血管不良事件发生的预测因子，并且PCSK9可能作为血小板激活的潜在机制。

原始出处：

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    2017-10-11 hbwxf

    #JACC#

    0

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    2017-09-19 宋威

    #预测因子#

    0

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    2017-09-19 12498568m50暂无昵称

    #ACC#

    0

  4. 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    2017-09-19 gjsgj

    #PSC#

    0

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    2017-09-19 ms3117646317107274

    #心血管不良事件#

    0

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    2017-09-19 zhouqu_8

    #房颤患者#

    0

  7. 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encryptionId=6cfd14e93a0, topicName=PSC)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=59b62453284, createdName=gjsgj, createdTime=Tue Sep 19 02:42:00 CST 2017, time=2017-09-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1511556, encodeId=18501511556b9, content=<a href='/topic/show?id=20cc51e3241' target=_blank style='color:#2F92EE;'>#心血管不良事件#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=51732, encryptionId=20cc51e3241, topicName=心血管不良事件)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=766910366053, createdName=ms3117646317107274, createdTime=Tue Sep 19 02:42:00 CST 2017, time=2017-09-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1614395, encodeId=d05316143950d, content=<a href='/topic/show?id=64f95426122' target=_blank style='color:#2F92EE;'>#房颤患者#</a>, beContent=null, 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time=2017-09-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=245021, encodeId=bff9245021ff, content=学习一下谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzaiabIFicf63hKvVMjL6aJlx4yX4UcXmzX9DyibCRcicq0QtCRWMaQKh8MYjE1D3EKUBopgiaGWYuqbeR/0, createdBy=0c2b1999806, createdName=三生有幸9135, createdTime=Sun Sep 17 13:11:06 CST 2017, time=2017-09-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=245014, encodeId=7f3c2450140a, content=学习受益匪浅.谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/Q3auHgzwzM4o2XVpJ6449yqDsjibydI5HnJ8MibGxNn4HZiaZib0bdfibbwoz3KQrIyN9AGxq36ZlZRNicYlPfOOWMtwgsajY6mGNFiaPclFdowjD0/0, createdBy=97bd1338592, createdName=清风拂面, createdTime=Sun Sep 17 12:42:35 CST 2017, time=2017-09-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=245007, encodeId=f41124500e7c, content=房颤还是应该用华法林吧, beContent=null, objectType=article, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/vi_32/iaAVWEsIJUkA1ITy3uL0lhHUhyaJibWgFtH4KbJuaLbY2WUK33jgCFyoZ8Eqx7eE7hCuZhytc1C5GRrfjVXN8lYg/0, createdBy=fcb82149579, createdName=183****7028, createdTime=Sun Sep 17 12:10:54 CST 2017, time=2017-09-17, status=1, ipAttribution=)]
    2017-09-17 189****7206

    学习了谢谢分享

    0

  8. 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encryptionId=6cfd14e93a0, topicName=PSC)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=59b62453284, createdName=gjsgj, createdTime=Tue Sep 19 02:42:00 CST 2017, time=2017-09-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1511556, encodeId=18501511556b9, content=<a href='/topic/show?id=20cc51e3241' target=_blank style='color:#2F92EE;'>#心血管不良事件#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=51732, encryptionId=20cc51e3241, topicName=心血管不良事件)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=766910366053, createdName=ms3117646317107274, createdTime=Tue Sep 19 02:42:00 CST 2017, time=2017-09-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1614395, encodeId=d05316143950d, content=<a href='/topic/show?id=64f95426122' target=_blank style='color:#2F92EE;'>#房颤患者#</a>, beContent=null, 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time=2017-09-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=245021, encodeId=bff9245021ff, content=学习一下谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzaiabIFicf63hKvVMjL6aJlx4yX4UcXmzX9DyibCRcicq0QtCRWMaQKh8MYjE1D3EKUBopgiaGWYuqbeR/0, createdBy=0c2b1999806, createdName=三生有幸9135, createdTime=Sun Sep 17 13:11:06 CST 2017, time=2017-09-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=245014, encodeId=7f3c2450140a, content=学习受益匪浅.谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/Q3auHgzwzM4o2XVpJ6449yqDsjibydI5HnJ8MibGxNn4HZiaZib0bdfibbwoz3KQrIyN9AGxq36ZlZRNicYlPfOOWMtwgsajY6mGNFiaPclFdowjD0/0, createdBy=97bd1338592, createdName=清风拂面, createdTime=Sun Sep 17 12:42:35 CST 2017, time=2017-09-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=245007, encodeId=f41124500e7c, content=房颤还是应该用华法林吧, beContent=null, objectType=article, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/vi_32/iaAVWEsIJUkA1ITy3uL0lhHUhyaJibWgFtH4KbJuaLbY2WUK33jgCFyoZ8Eqx7eE7hCuZhytc1C5GRrfjVXN8lYg/0, createdBy=fcb82149579, createdName=183****7028, createdTime=Sun Sep 17 12:10:54 CST 2017, time=2017-09-17, status=1, ipAttribution=)]
    2017-09-17 三生有幸9135

    学习一下谢谢分享

    0

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createdAvatar=https://wx.qlogo.cn/mmopen/Q3auHgzwzM4o2XVpJ6449yqDsjibydI5HnJ8MibGxNn4HZiaZib0bdfibbwoz3KQrIyN9AGxq36ZlZRNicYlPfOOWMtwgsajY6mGNFiaPclFdowjD0/0, createdBy=97bd1338592, createdName=清风拂面, createdTime=Sun Sep 17 12:42:35 CST 2017, time=2017-09-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=245007, encodeId=f41124500e7c, content=房颤还是应该用华法林吧, beContent=null, objectType=article, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/vi_32/iaAVWEsIJUkA1ITy3uL0lhHUhyaJibWgFtH4KbJuaLbY2WUK33jgCFyoZ8Eqx7eE7hCuZhytc1C5GRrfjVXN8lYg/0, createdBy=fcb82149579, createdName=183****7028, createdTime=Sun Sep 17 12:10:54 CST 2017, time=2017-09-17, status=1, ipAttribution=)]
    2017-09-17 清风拂面

    学习受益匪浅.谢谢分享

    0

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    2017-09-17 183****7028

    房颤还是应该用华法林吧

    0

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