JAMA Pediatr：对乙酰氨基酚可降低心脏手术患儿急性肾损伤风险

2018-05-15 zhangfan MedSci原创

研究认为，儿科心脏手术患者术后早期接受对乙酰氨基酚治疗可降低急性肾损伤风险

急性肾损伤(AKI)是儿科心脏手术患者的一种常见严重并发症，目前临床中主要着力于降低风险与早期识别，尚无有效的预防及治疗药物。心脏手术中红细胞释放游离血红蛋白及氧化损伤是造成AKI的重要因素，而理论上对乙酰氨基酚可通过降低游离血红蛋白的氧化状态预防AKI的发生。近日研究人员考察了术后早期服用对乙酰氨基酚对预防儿科心脏手术患者AKI的效果。

本次回顾性队列研究在2所III级儿童诊疗中心开展，28天以上，接受心脏手术的患儿参与研究，术后48小时内接受对乙酰氨基酚治疗，主要终点为术后1周内AKI发生率。

666名患儿参与研究，平均年龄6.5个月，341人(51.2%)发生AKI。未经调整前，AKI患儿体内对乙酰氨基酚含量低于非AKI患儿（47 vs 78mg/kg）。调整年龄、心肺转流时间、红细胞分布、术后低血压、肾毒性和先天性心脏手术评分风险后，对乙酰氨基酚对术后AKI具有保护作用(剂量每增加10mg/kg，比值比为0.86)。该结果在验证队列中(n=333)得到了确证。

研究认为，儿科心脏手术患者术后早期接受对乙酰氨基酚治疗可降低急性肾损伤风险。

原始出处：

Sara L. Van Driest et al. Association Between Early Postoperative Acetaminophen Exposure and Acute Kidney Injury in Pediatric Patients Undergoing Cardiac Surgery. JAMA Pediatr. May 14， 2018.

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2018-11-12 ms9608593228839890

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2018-11-30 feather89

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2018-06-08 tonychen21

#乙酰氨基酚#

47 0
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2018-05-23 易水河

还有这个作用吗?

73 0
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2018-05-17 lilili1104

#对乙酰氨基酚#

68 0
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2018-05-17 ms3046638856685384

#损伤#

27 0
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2018-05-15 虈亣靌

学习一下很不错

47 0
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2018-05-15 13718711b3m

学习了.获益匪浅.感谢分享

61 0
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2018-05-15 医者仁心5538

学习了

49 0

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