人呐,就是一坨走来走去的菌!

2018-05-13 荣荣 “医学界” 微信号

人体细胞中只有43%的细胞是人类的,其余都是人体的共生菌。从某意义上讲,此时身旁经过的每个人,我们眼睛看到的绝大部分都是他们的细菌——人是一坨走来走去的菌。人类——行走的菌群那下回是不是应该认真洗澡洗手,去除这些可怕的菌?no!无论我们清洗得多干净,身体的各个角落和缝隙还是会被这些微小的生物所覆盖。换句话说,我们始终和众多微生物共享着这具躯壳。从细胞数量上讲我们与微生物只是有点差距,但从基因数量上

人体细胞中只有43%的细胞是人类的,其余都是人体的共生菌。

从某意义上讲,此时身旁经过的每个人,我们眼睛看到的绝大部分都是他们的细菌——人是一坨走来走去的菌。

人类——行走的菌群

那下回是不是应该认真洗澡洗手,去除这些可怕的菌?

no!无论我们清洗得多干净,身体的各个角落和缝隙还是会被这些微小的生物所覆盖。换句话说,我们始终和众多微生物共享着这具躯壳。

从细胞数量上讲我们与微生物只是有点差距,但从基因数量上讲,差距就不止一点点了。

人类的基因组有2万多个基因,而人体微生物的所有基因大概是198万~1998万。这比例……大家自己可以算一下。

因此,加州理工学院的微生物学家Sarkis Mazmanian教授认为“我们不仅有一个基因组,我们身体微生物群的基因本质上是第二个基因组,而这也丰富了我们的活动。”

然而,我们身上“居住”的这数量庞大的菌群,可不仅仅是“居民”这么简单。它们既相互作用,又对我们的身体有着各种影响。

也许,你在某个重要场合念错的字就是你的菌群在作怪。

目前为止,我们人类与微生物的关系主要是“对立关系”——我们利用抗生素和疫苗对抗天花、结核、MRSA,挽救了大量的生命;但我们在消灭“坏菌”的同时,“好菌”也受到了伤害。

在过去50年里,传染病的发病率不断下降,但是自身免疫性疾病和过敏性疾病的发病率也在不断上升。

当然“细菌”并不总意味着“疾病”

马克斯·普朗克研究所的微生物科学系主任Ruth Ley教授强调道,它们对我们的健康至关重要,毕竟“你的身体不只有你”,还有细菌、真菌、病毒、古生菌,而它们最爱待的地方是我们幽深、黑暗又缺氧的肠道。

因此,人类的消化道拥有大量且多样的菌群,帮助我们消化、增强免疫力。

肠道菌群与多种疾病相关,肠道疾病自不用说;在肠外,研究人员发现这些微生物还与帕金森病、抗癌药物疗效,甚至抑郁、自闭症相关。

“脑-肠轴”早已不是什么前沿的说法。十九世纪末,William James 和Carl Lange医生便提出,情绪反应可能是由内脏传递给大脑的信号直接调节的。

脑-肠轴,中枢神经系统与肠道菌群的复杂纠葛

迷走神经是肠道菌群与中枢神经之间的“电话线”,肠壁通过迷走神经与中枢神经系统保持双向沟通——大脑“指挥”肠道活动,肠道通过迷走神经与大脑“交流”。

因此外部环境因素对大脑造成的压力会影响肠道健康,比如很多人紧张、压抑的时候会出现腹泻或排便习惯改变;同样,肠道菌群也可能影响着我们的情绪状态,研究人员用益生菌可以治疗小鼠结肠炎模型中的类似焦虑的症状。

所以说,我们过得好不好,有时还得问我们身上的菌群过得好不好,而这在新生儿身上体现得更明显。

新生儿一离开子宫,就被共生菌所包围。有研究发现,新生儿肠道中的这些微生物可以促进循环中中性粒细胞的增加,从而保护他们免受感染;围产期抗生素治疗会改变肠道微生物,损害中性粒细胞,使新生儿容易受到有害菌的侵袭。

另一项研究也发现,母乳喂养可以帮助早产儿菌群健康发育,预防坏死性小肠结肠炎。

母乳中的成分可以帮助婴儿肠道建立健康的微生物群

这些肉眼看不见的微生物不仅占据了我们的身体,甚至还可能决定我们的命运。

未来是属于我们的,也是属于微生物的,但归根结底还是属于我们的。

毕竟我们才是地球上最高级的动物,懂得发挥主观能动性——越来越多的证据表明,修复某人的微生物群可以促使某个疾病缓解。

据说,由于研究发现移植高水平球员粪便菌群,可显着提高运动水平和精神状态,“梅西”牌粪菌胶囊的黑市价格已直逼一台特斯拉。

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createdBy=a35e76003, createdName=871538379, createdTime=Mon May 14 05:49:48 CST 2018, time=2018-05-14, status=1, ipAttribution=)]
    2018-05-17 荒郊野树

    学习

    0

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    2018-05-14 明月清辉

    谢谢分享.学习了

    0

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createdAvatar=https://wx.qlogo.cn/mmopen/ajNVdqHZLLCclExeQ6LOGMD4dTsia4Ty4HtZCxRmG5vO5XIKfKX3a3vusfhHSej4Iib517vmhFW7RQgh7bpDp1yw/0, createdBy=50951609779, createdName=baihao215, createdTime=Mon May 14 08:09:21 CST 2018, time=2018-05-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=314927, encodeId=899431492e4e, content=好文献.学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b5a62240667, createdName=张新亮1853311252142e2fm, createdTime=Mon May 14 06:53:37 CST 2018, time=2018-05-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=314921, encodeId=9e5931492180, content=学习一下谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=16, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzaiabIFicf63hKvVMjL6aJlx4yX4UcXmzX9DyibCRcicq0QtCRWMaQKh8MYjE1D3EKUBopgiaGWYuqbeR/0, createdBy=0c2b1999806, createdName=三生有幸9135, createdTime=Mon May 14 06:49:57 CST 2018, time=2018-05-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=314906, encodeId=c64231490664, content=学习了.谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7c592194322, createdName=1209e435m98(暂无昵称), createdTime=Mon May 14 06:21:53 CST 2018, time=2018-05-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=314891, encodeId=3d6b314891c2, content=我们不是我们 我们是群菌落, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a35e76003, createdName=871538379, createdTime=Mon May 14 05:49:48 CST 2018, time=2018-05-14, status=1, ipAttribution=)]
    2018-05-14 Vita Liang

    谢谢.学习了

    0

  4. 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createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzaiabIFicf63hKvVMjL6aJlx4yX4UcXmzX9DyibCRcicq0QtCRWMaQKh8MYjE1D3EKUBopgiaGWYuqbeR/0, createdBy=0c2b1999806, createdName=三生有幸9135, createdTime=Mon May 14 06:49:57 CST 2018, time=2018-05-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=314906, encodeId=c64231490664, content=学习了.谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7c592194322, createdName=1209e435m98(暂无昵称), createdTime=Mon May 14 06:21:53 CST 2018, time=2018-05-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=314891, encodeId=3d6b314891c2, content=我们不是我们 我们是群菌落, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a35e76003, createdName=871538379, createdTime=Mon May 14 05:49:48 CST 2018, time=2018-05-14, status=1, ipAttribution=)]
    2018-05-14 午后阳光

    肠道菌群和人体各系统健康和疾病相关.学习了

    0

  5. 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createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzaiabIFicf63hKvVMjL6aJlx4yX4UcXmzX9DyibCRcicq0QtCRWMaQKh8MYjE1D3EKUBopgiaGWYuqbeR/0, createdBy=0c2b1999806, createdName=三生有幸9135, createdTime=Mon May 14 06:49:57 CST 2018, time=2018-05-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=314906, encodeId=c64231490664, content=学习了.谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7c592194322, createdName=1209e435m98(暂无昵称), createdTime=Mon May 14 06:21:53 CST 2018, time=2018-05-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=314891, encodeId=3d6b314891c2, content=我们不是我们 我们是群菌落, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a35e76003, createdName=871538379, createdTime=Mon May 14 05:49:48 CST 2018, time=2018-05-14, status=1, ipAttribution=)]
    2018-05-14 龙胆草

    学习谢谢分享

    0

  6. 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createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzaiabIFicf63hKvVMjL6aJlx4yX4UcXmzX9DyibCRcicq0QtCRWMaQKh8MYjE1D3EKUBopgiaGWYuqbeR/0, createdBy=0c2b1999806, createdName=三生有幸9135, createdTime=Mon May 14 06:49:57 CST 2018, time=2018-05-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=314906, encodeId=c64231490664, content=学习了.谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7c592194322, createdName=1209e435m98(暂无昵称), createdTime=Mon May 14 06:21:53 CST 2018, time=2018-05-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=314891, encodeId=3d6b314891c2, content=我们不是我们 我们是群菌落, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a35e76003, createdName=871538379, createdTime=Mon May 14 05:49:48 CST 2018, time=2018-05-14, status=1, ipAttribution=)]
    2018-05-14 baihao215

    哈哈.大实话啊.学习了

    0

  7. 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createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzaiabIFicf63hKvVMjL6aJlx4yX4UcXmzX9DyibCRcicq0QtCRWMaQKh8MYjE1D3EKUBopgiaGWYuqbeR/0, createdBy=0c2b1999806, createdName=三生有幸9135, createdTime=Mon May 14 06:49:57 CST 2018, time=2018-05-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=314906, encodeId=c64231490664, content=学习了.谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7c592194322, createdName=1209e435m98(暂无昵称), createdTime=Mon May 14 06:21:53 CST 2018, time=2018-05-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=314891, encodeId=3d6b314891c2, content=我们不是我们 我们是群菌落, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a35e76003, createdName=871538379, createdTime=Mon May 14 05:49:48 CST 2018, time=2018-05-14, status=1, ipAttribution=)]
    2018-05-14 张新亮1853311252142e2fm

    好文献.学习了

    0

  8. 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createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzaiabIFicf63hKvVMjL6aJlx4yX4UcXmzX9DyibCRcicq0QtCRWMaQKh8MYjE1D3EKUBopgiaGWYuqbeR/0, createdBy=0c2b1999806, createdName=三生有幸9135, createdTime=Mon May 14 06:49:57 CST 2018, time=2018-05-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=314906, encodeId=c64231490664, content=学习了.谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7c592194322, createdName=1209e435m98(暂无昵称), createdTime=Mon May 14 06:21:53 CST 2018, time=2018-05-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=314891, encodeId=3d6b314891c2, content=我们不是我们 我们是群菌落, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a35e76003, createdName=871538379, createdTime=Mon May 14 05:49:48 CST 2018, time=2018-05-14, status=1, ipAttribution=)]
    2018-05-14 三生有幸9135

    学习一下谢谢分享

    0

  9. 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createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzaiabIFicf63hKvVMjL6aJlx4yX4UcXmzX9DyibCRcicq0QtCRWMaQKh8MYjE1D3EKUBopgiaGWYuqbeR/0, createdBy=0c2b1999806, createdName=三生有幸9135, createdTime=Mon May 14 06:49:57 CST 2018, time=2018-05-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=314906, encodeId=c64231490664, content=学习了.谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7c592194322, createdName=1209e435m98(暂无昵称), createdTime=Mon May 14 06:21:53 CST 2018, time=2018-05-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=314891, encodeId=3d6b314891c2, content=我们不是我们 我们是群菌落, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a35e76003, createdName=871538379, createdTime=Mon May 14 05:49:48 CST 2018, time=2018-05-14, status=1, ipAttribution=)]
    2018-05-14 1209e435m98(暂无昵称)

    学习了.谢谢分享

    0

  10. 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createdBy=a35e76003, createdName=871538379, createdTime=Mon May 14 05:49:48 CST 2018, time=2018-05-14, status=1, ipAttribution=)]
    2018-05-14 871538379

    我们不是我们 我们是群菌落

    0

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