JAHA:早期情绪症状预测青少年颈动脉粥样硬化

2019-01-18 xing.T MedSci原创

由此可见,在这个大型出生队列中,青春期ESs与年轻成人颈动脉内膜中层厚度之间存在纵向相关。这种关联是直接的,不是由传统的心血管危险因素所介导。按性别进行的相互作用可能对设计未来的干预措施具有重要指导意义。

情绪障碍是动脉粥样硬化和随后的血管疾病的危险因素。然而,尚不清楚情绪症状(ESs)是否对血管疾病有直接影响。近日,心血管疾病领域权威杂志JAHA上发表了一篇研究文章,该研究的目的是分析早期ESs对年轻成人颈动脉粥样硬化的影响。

研究人员评估了1993年Pelotas出生队列中11岁和15岁的ES与18岁时颈动脉内膜中层厚度之间的关联(n=5249,具有完整的心理健康数据n=4336)。研究人员使用优势和困难问卷评估了ES,并使用广义增强回归模型进行倾向评分加权分析以调整暴露和结果之间的潜在混淆。研究人员还评估了传统的心血管危险因素是否可以调节这种关系。

在11岁和15岁时较高频率调整后的ES导致18岁时颈动脉内膜中层厚度分别增加1.84和2.58μm(均P<0.001)。ES对动脉粥样硬化的纵向作用是直接的,并且不是由传统的心血管危险因素所介导。15岁时男性可显著增强ESs对18岁时颈动脉内膜中层厚度的影响(相互作用P<0.001):尽管较高频率ES的导致女性平均增加1.14μm(P<0.05),它导致男性平均增加5.83μm(P<0.001)。

由此可见,在这个大型出生队列中,青春期ESs与年轻成人颈动脉内膜中层厚度之间存在纵向相关。这种关联是直接的,不是由传统的心血管危险因素所介导。按性别进行的相互作用可能对设计未来的干预措施具有重要指导意义。

原始出处:


Cristiano Tschiedel.et al.Early Emotional Symptoms Predicting Carotid Atherosclerosis in Youth: Results From a Birth Cohort in Latin America.JAHA.2019.https://www.ahajournals.org/doi/10.1161/JAHA.118.011011

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