CELL HOST MICROBE:体内微生物生态平衡不仅影响健康,还关系衰老

2017-04-19 MedSci MedSci原创

目前认为体循环炎症介质的水平随着年龄增加而增加,但是关于年龄相关的炎症的根本原因仍有争议的。

近日,国际杂志CELL HOST MICROBE上在线发表一项与年龄有关的微生物生态失调促进肠道通透性,系统性炎症和巨噬细胞功能障碍的研究。

目前认为体循环炎症介质的水平随着年龄增加而增加,但是关于年龄相关的炎症的根本原因仍有争议的。

研究实验表明,无菌环境中培养小鼠,相比于正常小鼠,在衰老后,这些无菌小鼠没有表现出肠道通透性和细菌副产物的增加,血液中的促炎性细胞因子也没有增加。此外,无菌小鼠中活到600天高龄的比例更高,这些老年无菌小鼠的巨噬细胞仍然维持着抗菌能力。这些发现表明,随着年龄增长,肠道微生物的变化会削弱肠道的屏障作用,导致细菌副产物被释放出来,而这些产物会诱发炎症,削弱免疫功能,并减少寿命。炎症和微生物之间的关系是双向的。在体内缺乏TNF的小鼠(未被炎症感染)身上,并没有观察到随着年龄增长而出现的肠道微生物成分变化。此外,一种批准用于人类的抗TNF药物能够逆转随着年龄增加而出现的微生物变化。

研究表明小鼠肠道微生物是与年龄相关的炎症以及过早死亡的原因之一。老年小鼠的肠道微生物成分失衡会导致肠道组织易于“泄漏”,使引发炎症的细菌副产物释放出来,并削弱免疫功能。据此也许能够通过操控体内微生物来改善肠道健康并降低与衰老相关的炎症产生新的治疗策略。

原始出处:

Elena F. Verdú, Michael G. Surette, Dawn M.E. Bowdish. Age-Associated Microbial Dysbiosis Promotes Intestinal Permeability, Systemic Inflammation, and Macrophage Dysfunction. Volume 21, Issue 4, p455–466.e4, 12 April 2017.

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    2017-09-07 xjy02
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    2018-03-21 维他命
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    2017-04-22 doctorJiangchao

    继续学习。

    0

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    2017-04-20 绛珠草小姐

    学习了,谢谢

    0

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    2017-04-19 lovetcm

    微生物组的失衡与衰老的关系不仅仅是因,也可能是果

    0

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