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ChemBioChem： 用糖分子检测癌症

2017-08-14 MedSci MedSci原创

糖分子
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半乳糖凝集素（Galectins）作为凝集素家族的一员，是近年来一个有前景的癌症研究蛋白源。其代表是galectin - 1。它分布广泛，位于所有细胞表面，其中在肿瘤细胞中高表达。这使它成为肿瘤诊断和治疗的一个有趣的新靶点。来自德国巴伐利亚州维尔茨堡市的Julius-Maximilians-Universit？t（JMU）有机化学研究所的Jürgen Seibel教授解释说："其中，已知galec

半乳糖凝集素（Galectins）作为凝集素家族的一员，是近年来一个有前景的癌症研究蛋白源。其代表是galectin - 1。它分布广泛，位于所有细胞表面，其中在肿瘤细胞中高表达。这使它成为肿瘤诊断和治疗的一个有趣的新靶点。来自德国巴伐利亚州维尔茨堡市的Julius-Maximilians-Universit？t（JMU）有机化学研究所的Jürgen Seibel教授解释说："其中，已知galectin - 1可以将免疫系统的肿瘤细胞隐藏起来。"最近的研究表明，当galectin - 1被阻断时，免疫系统可以识别肿瘤并对其进行T细胞攻击。含有分子对接位点的糖分子因此，毫无疑问，galectin - 1已经成为研究的主要焦点。Seibel和他的同事Clemens Grimm博士对这种蛋白质的一个特定的部分感兴趣，即所谓的碳水化合物识别结构域。他们发表在《化学生物化学》杂志上的研究称，他们现在已经设计出一种复杂的糖分子，与该结构域完全匹配。Seibel说："我们已经将糖分子与一个对接位点进行配对，例如通过荧光染料或药物将其连接起来。此外，研究人员通过高分辨率X射线其分子与galectin

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    2018-04-04 sunylz

    #Bio#

    0

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    2017-08-16 chunjianf

    学习了，谢谢分享

    0

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    2017-08-15 明月清辉

    谢谢分享，学习了

    0

  4. 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createdAvatar=https://wx.qlogo.cn/mmopen/Pw2csslt7CukWiabqiblnQAXaDEiaxhu025c3P0XshccTrbvGWBjKvnHIxbK3vqa80P7WGIFuicCFet97TicrNKpgB3TdabxP1vMh/0, createdBy=28851960965, createdName=榄枷檬, createdTime=Tue Aug 15 07:10:38 CST 2017, time=2017-08-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=233693, encodeId=1cb623369301, content=学习了，谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=49, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/Q3auHgzwzM4Cr8ibeWnmTmmC1lthicNVicicXTX7Mn9OEib5S1eHg4jhM9usWmW2NBVm6NaJurhgeMl3UJ1gujuaQuIX7icVSa8F4JoFPCfib0Prsk/0, createdBy=b5bb2069360, createdName=cherry bomb, createdTime=Tue Aug 15 06:51:47 CST 2017, time=2017-08-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=233674, encodeId=11542336e4f0, content=学习谢谢分享, beContent=null, objectType=article, channel=null, level=null, 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content=值得推荐一下, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/ajNVdqHZLLBWOEtiahpXHGVdbFId5PLgK775YNA1ria3lM9KsJT6iczgIhov5sobd1Nr0raUBP58GkUDzvfDic9RCg/0, createdBy=0d021989245, createdName=189****1577, createdTime=Tue Aug 15 06:21:08 CST 2017, time=2017-08-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=233655, encodeId=ef4c23365513, content=好好学习看看, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=45101626056, createdName=忠诚向上, createdTime=Tue Aug 15 06:19:41 CST 2017, time=2017-08-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=233639, encodeId=196d233639c6, content=有前景, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=18741984753, createdName=smartxiuxiu, createdTime=Tue Aug 15 05:09:41 CST 2017, time=2017-08-15, status=1, ipAttribution=)]
    2017-08-15 榄枷檬

    谢谢分享

    0

  5. 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content=值得推荐一下, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/ajNVdqHZLLBWOEtiahpXHGVdbFId5PLgK775YNA1ria3lM9KsJT6iczgIhov5sobd1Nr0raUBP58GkUDzvfDic9RCg/0, createdBy=0d021989245, createdName=189****1577, createdTime=Tue Aug 15 06:21:08 CST 2017, time=2017-08-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=233655, encodeId=ef4c23365513, content=好好学习看看, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=45101626056, createdName=忠诚向上, createdTime=Tue Aug 15 06:19:41 CST 2017, time=2017-08-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=233639, encodeId=196d233639c6, content=有前景, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=18741984753, createdName=smartxiuxiu, createdTime=Tue Aug 15 05:09:41 CST 2017, time=2017-08-15, status=1, ipAttribution=)]
    2017-08-15 cherry bomb

    学习了，谢谢分享

    0

  6. 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channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=18741984753, createdName=smartxiuxiu, createdTime=Tue Aug 15 05:09:41 CST 2017, time=2017-08-15, status=1, ipAttribution=)]
    2017-08-15 龙胆草

    学习谢谢分享

    0

  7. 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content=值得推荐一下, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/ajNVdqHZLLBWOEtiahpXHGVdbFId5PLgK775YNA1ria3lM9KsJT6iczgIhov5sobd1Nr0raUBP58GkUDzvfDic9RCg/0, createdBy=0d021989245, createdName=189****1577, createdTime=Tue Aug 15 06:21:08 CST 2017, time=2017-08-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=233655, encodeId=ef4c23365513, content=好好学习看看, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=45101626056, createdName=忠诚向上, createdTime=Tue Aug 15 06:19:41 CST 2017, time=2017-08-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=233639, encodeId=196d233639c6, content=有前景, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=18741984753, createdName=smartxiuxiu, createdTime=Tue Aug 15 05:09:41 CST 2017, time=2017-08-15, status=1, ipAttribution=)]
    2017-08-15 半夏微凉

    学习了谢谢分享

    0

  8. [GetPortalCommentsPageByObjectIdResponse(id=1917609, encodeId=ed42191e609be, content=<a href='/topic/show?id=4f26341994' target=_blank style='color:#2F92EE;'>#Bio#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3419, encryptionId=4f26341994, topicName=Bio)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=12de429, createdName=sunylz, createdTime=Wed Apr 04 10:05:00 CST 2018, time=2018-04-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=233946, encodeId=81c623394626, content=学习了，谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=51, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NfNLvzZhgPxRk75KAEKrLGic0S0IvH1aNynsEFQWiaNKdtzvtwj2kafCoPg2icYVbrfBCFiaS74X1uEiaaTTY1H9Xyem/0, createdBy=cec11614828, 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createdAvatar=https://wx.qlogo.cn/mmopen/Pw2csslt7CukWiabqiblnQAXaDEiaxhu025c3P0XshccTrbvGWBjKvnHIxbK3vqa80P7WGIFuicCFet97TicrNKpgB3TdabxP1vMh/0, createdBy=28851960965, createdName=榄枷檬, createdTime=Tue Aug 15 07:10:38 CST 2017, time=2017-08-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=233693, encodeId=1cb623369301, content=学习了，谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=49, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/Q3auHgzwzM4Cr8ibeWnmTmmC1lthicNVicicXTX7Mn9OEib5S1eHg4jhM9usWmW2NBVm6NaJurhgeMl3UJ1gujuaQuIX7icVSa8F4JoFPCfib0Prsk/0, createdBy=b5bb2069360, createdName=cherry bomb, createdTime=Tue Aug 15 06:51:47 CST 2017, time=2017-08-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=233674, encodeId=11542336e4f0, content=学习谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=60, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4Nd44v3xHnnictn9UpctwtH62EPQ59TMdI9lnqHMgQ16nH7GmGCfpzicsHgjibYVk6vwSpXrC86gMibRkoaIzf5HwSz7/0, createdBy=78cc1691107, createdName=龙胆草, createdTime=Tue Aug 15 06:32:54 CST 2017, time=2017-08-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=233672, encodeId=75212336e23b, content=学习了谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo5nmIH5IQqCKjJgSCuicPWUWOUcdqt1ROPnEiaOYN4pSHibDv8la3OxNLalvuvUXn8clpJlrpuyTpckgt9OPkeSSdT/0, createdBy=8fd71930726, createdName=半夏微凉, createdTime=Tue Aug 15 06:31:13 CST 2017, time=2017-08-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=233660, encodeId=645123366065, content=值得推荐一下, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/ajNVdqHZLLBWOEtiahpXHGVdbFId5PLgK775YNA1ria3lM9KsJT6iczgIhov5sobd1Nr0raUBP58GkUDzvfDic9RCg/0, createdBy=0d021989245, createdName=189****1577, createdTime=Tue Aug 15 06:21:08 CST 2017, time=2017-08-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=233655, encodeId=ef4c23365513, content=好好学习看看, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=45101626056, createdName=忠诚向上, createdTime=Tue Aug 15 06:19:41 CST 2017, time=2017-08-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=233639, encodeId=196d233639c6, content=有前景, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=18741984753, createdName=smartxiuxiu, createdTime=Tue Aug 15 05:09:41 CST 2017, time=2017-08-15, status=1, ipAttribution=)]
    2017-08-15 189****1577

    值得推荐一下

    0

  9. 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content=值得推荐一下, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/ajNVdqHZLLBWOEtiahpXHGVdbFId5PLgK775YNA1ria3lM9KsJT6iczgIhov5sobd1Nr0raUBP58GkUDzvfDic9RCg/0, createdBy=0d021989245, createdName=189****1577, createdTime=Tue Aug 15 06:21:08 CST 2017, time=2017-08-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=233655, encodeId=ef4c23365513, content=好好学习看看, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=45101626056, createdName=忠诚向上, createdTime=Tue Aug 15 06:19:41 CST 2017, time=2017-08-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=233639, encodeId=196d233639c6, content=有前景, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=18741984753, createdName=smartxiuxiu, createdTime=Tue Aug 15 05:09:41 CST 2017, time=2017-08-15, status=1, ipAttribution=)]
    2017-08-15 忠诚向上

    好好学习看看

    0

  10. 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content=值得推荐一下, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/ajNVdqHZLLBWOEtiahpXHGVdbFId5PLgK775YNA1ria3lM9KsJT6iczgIhov5sobd1Nr0raUBP58GkUDzvfDic9RCg/0, createdBy=0d021989245, createdName=189****1577, createdTime=Tue Aug 15 06:21:08 CST 2017, time=2017-08-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=233655, encodeId=ef4c23365513, content=好好学习看看, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=45101626056, createdName=忠诚向上, createdTime=Tue Aug 15 06:19:41 CST 2017, time=2017-08-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=233639, encodeId=196d233639c6, content=有前景, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=18741984753, createdName=smartxiuxiu, createdTime=Tue Aug 15 05:09:41 CST 2017, time=2017-08-15, status=1, ipAttribution=)]
    2017-08-15 smartxiuxiu

    有前景

    0

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