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J Endod：液压式根管封闭水门汀的界面特性和骨细胞相容性

2018-02-15 lishiting MedSci原创

封闭剂性能
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根管充填的稳定性和长期成功依赖于对封闭剂的选择，因为封闭剂可以与牙本质结合并且能够稳定固化牙胶锥核。另外，封闭剂需要无毒副作用，因为封闭剂毒性会导致治疗的失败。这篇研究的目的是为了检测3种液压式根管封闭剂的封闭剂-牙本质界面，以及评估它们的骨细胞相容性并与AH Plus (Dentsply DeTrey GmbH, Konstanz, Germany)相比较。

根管充填的稳定性和长期成功依赖于对封闭剂的选择，因为封闭剂可以与牙本质结合并且能够稳定固化牙胶锥核。另外，封闭剂需要无毒副作用，因为封闭剂毒性会导致治疗的失败。这篇研究的目的是为了检测3种液压式根管封闭剂的封闭剂-牙本质界面，以及评估它们的骨细胞相容性并与AH Plus (Dentsply DeTrey GmbH， Konstanz， Germany)相比较。

研究共检测评估4种根管封闭剂：AH Plus， MTA Fillapex (Angelus， Londrina， Brazil)， BioRoot RCS (Septodont， Saint-Maur-des-Fossés， France)和Endoseal (Maruchi， Wonju-si， Gangwon-do， South Korea)。通过扫描电镜和能量色散光谱学检测材料的特性。通过共聚焦显微镜和扫描电镜评估封闭剂-牙本质界面。通过直接接触法和ALP活性检测细胞的代谢功能，以此来评估材料的生物相容性。

结果显示，尽管硅酸三钙类封闭剂具有相似的化学作用和分类，但它们的基本成分及微结构表现出明显的不同。BioRoot RCS不含铝，并且所有封闭剂均含有不同的X线阻射元素。另外，封闭剂对牙本质小管的渗透性和其界面特性均有所不同。所有硅酸三钙类封闭剂均表现出硅元素从材料向牙齿的迁移。直接接触试验和ALP活性检测均显示，MTA Fillapex和BioRoot RCS具有最好的骨细胞生物性。

结论：使用液压式硅酸三钙类封闭剂已经为牙髓病学引入了多种不同的材料类型。这些材料主要与其它封闭剂的差异之处在于它们的液压特性以及它们与周围环境的相互作用。尽管封闭剂测试显示它们具有相似的化学作用，但是其骨细胞相容性及粘接机制还是不尽相同。

原始出处：

Kebudi Benezra M， Schembri Wismayer P， et al. Interfacial Characteristics and Cytocompatibility of Hydraulic Sealer Cements. J Endod. 2018 Feb 2. pii： S0099-2399(17)31238-4. doi： 10.1016/j.joen.2017.11.011.

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createdName=xiaotao112411, createdTime=Fri Feb 23 11:06:45 CST 2018, time=2018-02-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=290218, encodeId=25dc29021869, content=学习学习学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/11/05/dc628308c49d4aa82335673176ebb6d3.jpg, createdBy=153c1955083, createdName=xiaotao112411, createdTime=Fri Feb 23 11:06:42 CST 2018, time=2018-02-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=290217, encodeId=1e2529021e0a, content=学习学习学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/11/05/dc628308c49d4aa82335673176ebb6d3.jpg, createdBy=153c1955083, createdName=xiaotao112411, createdTime=Fri Feb 23 11:06:38 CST 2018, time=2018-02-23, status=1, ipAttribution=)]
    2018-02-24 xiaotao112411

    学习学习学习

    0

  5. 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status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=290322, encodeId=4d0f290322bd, content=学习学习学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=54, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/11/05/dc628308c49d4aa82335673176ebb6d3.jpg, createdBy=153c1955083, createdName=xiaotao112411, createdTime=Sat Feb 24 00:28:16 CST 2018, time=2018-02-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=290321, encodeId=756129032131, content=学习学习学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/11/05/dc628308c49d4aa82335673176ebb6d3.jpg, createdBy=153c1955083, createdName=xiaotao112411, createdTime=Sat Feb 24 00:28:12 CST 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createdTime=Sat Feb 24 00:28:05 CST 2018, time=2018-02-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=290318, encodeId=883429031811, content=学习学习学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/11/05/dc628308c49d4aa82335673176ebb6d3.jpg, createdBy=153c1955083, createdName=xiaotao112411, createdTime=Sat Feb 24 00:27:59 CST 2018, time=2018-02-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=290219, encodeId=5b79290219e8, content=学习学习学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/11/05/dc628308c49d4aa82335673176ebb6d3.jpg, createdBy=153c1955083, createdName=xiaotao112411, createdTime=Fri Feb 23 11:06:45 CST 2018, time=2018-02-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=290218, encodeId=25dc29021869, content=学习学习学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/11/05/dc628308c49d4aa82335673176ebb6d3.jpg, createdBy=153c1955083, createdName=xiaotao112411, createdTime=Fri Feb 23 11:06:42 CST 2018, time=2018-02-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=290217, encodeId=1e2529021e0a, content=学习学习学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/11/05/dc628308c49d4aa82335673176ebb6d3.jpg, createdBy=153c1955083, createdName=xiaotao112411, createdTime=Fri Feb 23 11:06:38 CST 2018, time=2018-02-23, status=1, ipAttribution=)]
    2018-02-24 xiaotao112411

    学习学习学习

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=290324, encodeId=fe2c29032496, content=学习学习学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=64, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/11/05/dc628308c49d4aa82335673176ebb6d3.jpg, createdBy=153c1955083, createdName=xiaotao112411, createdTime=Sat Feb 24 00:28:24 CST 2018, time=2018-02-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=290323, encodeId=3b96290323b5, content=学习学习学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=60, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/11/05/dc628308c49d4aa82335673176ebb6d3.jpg, createdBy=153c1955083, createdName=xiaotao112411, createdTime=Sat Feb 24 00:28:20 CST 2018, time=2018-02-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=290322, encodeId=4d0f290322bd, content=学习学习学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=54, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/11/05/dc628308c49d4aa82335673176ebb6d3.jpg, createdBy=153c1955083, createdName=xiaotao112411, createdTime=Sat Feb 24 00:28:16 CST 2018, time=2018-02-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=290321, encodeId=756129032131, content=学习学习学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/11/05/dc628308c49d4aa82335673176ebb6d3.jpg, createdBy=153c1955083, createdName=xiaotao112411, createdTime=Sat Feb 24 00:28:12 CST 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createdTime=Sat Feb 24 00:28:05 CST 2018, time=2018-02-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=290318, encodeId=883429031811, content=学习学习学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/11/05/dc628308c49d4aa82335673176ebb6d3.jpg, createdBy=153c1955083, createdName=xiaotao112411, createdTime=Sat Feb 24 00:27:59 CST 2018, time=2018-02-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=290219, encodeId=5b79290219e8, content=学习学习学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/11/05/dc628308c49d4aa82335673176ebb6d3.jpg, createdBy=153c1955083, createdName=xiaotao112411, createdTime=Fri Feb 23 11:06:45 CST 2018, time=2018-02-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=290218, encodeId=25dc29021869, content=学习学习学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/11/05/dc628308c49d4aa82335673176ebb6d3.jpg, createdBy=153c1955083, createdName=xiaotao112411, createdTime=Fri Feb 23 11:06:42 CST 2018, time=2018-02-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=290217, encodeId=1e2529021e0a, content=学习学习学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/11/05/dc628308c49d4aa82335673176ebb6d3.jpg, createdBy=153c1955083, createdName=xiaotao112411, createdTime=Fri Feb 23 11:06:38 CST 2018, time=2018-02-23, status=1, ipAttribution=)]
    2018-02-24 xiaotao112411

    学习学习学习

    0

  7. 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status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=290322, encodeId=4d0f290322bd, content=学习学习学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=54, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/11/05/dc628308c49d4aa82335673176ebb6d3.jpg, createdBy=153c1955083, createdName=xiaotao112411, createdTime=Sat Feb 24 00:28:16 CST 2018, time=2018-02-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=290321, encodeId=756129032131, content=学习学习学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/11/05/dc628308c49d4aa82335673176ebb6d3.jpg, createdBy=153c1955083, createdName=xiaotao112411, createdTime=Sat Feb 24 00:28:12 CST 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createdTime=Sat Feb 24 00:28:05 CST 2018, time=2018-02-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=290318, encodeId=883429031811, content=学习学习学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/11/05/dc628308c49d4aa82335673176ebb6d3.jpg, createdBy=153c1955083, createdName=xiaotao112411, createdTime=Sat Feb 24 00:27:59 CST 2018, time=2018-02-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=290219, encodeId=5b79290219e8, content=学习学习学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/11/05/dc628308c49d4aa82335673176ebb6d3.jpg, createdBy=153c1955083, createdName=xiaotao112411, createdTime=Fri Feb 23 11:06:45 CST 2018, time=2018-02-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=290218, encodeId=25dc29021869, content=学习学习学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/11/05/dc628308c49d4aa82335673176ebb6d3.jpg, createdBy=153c1955083, createdName=xiaotao112411, createdTime=Fri Feb 23 11:06:42 CST 2018, time=2018-02-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=290217, encodeId=1e2529021e0a, content=学习学习学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/11/05/dc628308c49d4aa82335673176ebb6d3.jpg, createdBy=153c1955083, createdName=xiaotao112411, createdTime=Fri Feb 23 11:06:38 CST 2018, time=2018-02-23, status=1, ipAttribution=)]
    2018-02-24 xiaotao112411

    学习学习学习

    0

  8. 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    2018-02-23 xiaotao112411

    学习学习学习

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    2018-02-23 xiaotao112411

    学习学习学习

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  10. 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    2018-02-23 xiaotao112411

    学习学习学习

    0

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