JCEM:1岁幼儿体内的成纤维细胞生长因子23(FGF23)浓度受哪些因素调控?

2017-10-31 MedSci MedSci原创

背景:磷是人体内最丰富的元素之一,体内磷的多以磷酸盐(PO4)形式存在。成人正常血浆PO4浓度介于2.5~4.5mg/dl(0.81-1.45mmol/L),婴儿PO4要高50%,儿童高30%,大概是因为生长需要较高的磷酸盐。成纤维细胞生长因子23(FGF23)在磷酸盐代谢中起着重要的作用,但目前的研究不能充分解释它的调节特征。目的:本研究探讨了在儿童早期时FGF23受哪些因素调控,特别是性别和铁

背景:磷是人体内最丰富的元素之一,体内磷的多以磷酸盐(PO4)形式存在。成人正常血浆PO4浓度介于2.5~4.5mg/dl(0.81-1.45mmol/L),婴儿PO4要高50%,儿童高30%,大概是因为生长需要较高的磷酸盐。成纤维细胞生长因子23(FGF23)在磷酸盐代谢中起着重要的作用,但目前的研究不能充分解释它的调节特征。目的:本研究探讨了在儿童早期时FGF23受哪些因素调控,特别是性别和铁状态。方法:这是一项横断面研究,研究涉及1岁的幼儿。来自芬兰赫尔辛--Katiloopisto妇产科医院的研究人员招募了出生体重适于胎龄的健康足月儿,对他们进行了维生素D测试。在幼儿12个月时,研究人员随访了他们的血清FGF23、25羟维生素D(25OHD)、磷酸钙、甲状旁腺激素(PTH)和铁营养状况。研究纳入了所有721名幼儿(51%为女孩)的完整数据。主要观察指标:幼儿1岁时的成熟全段和C段FGF23浓度和铁状态。结果:女孩比男孩的全段FGF23浓度要高,中位数(IQR)分别为44.4(36.8,51.9)pg/ml和40.9(34.5,49)pg/ml(P<0.001)。男孩和女孩的C段

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    2018-09-27 achengzhao
  2. 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  4. [GetPortalCommentsPageByObjectIdResponse(id=2063066, encodeId=e6a620630667e, content=<a href='/topic/show?id=14fb10264d7' target=_blank style='color:#2F92EE;'>#JCE#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10264, encryptionId=14fb10264d7, topicName=JCE)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e656479, createdName=achengzhao, createdTime=Thu Sep 27 16:43:00 CST 2018, time=2018-09-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1956606, encodeId=544219566062b, content=<a href='/topic/show?id=e15ce3940f' target=_blank style='color:#2F92EE;'>#FGF23#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=52, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7394, encryptionId=e15ce3940f, topicName=FGF23)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/JicbM9ddhTaNkKdhKQ8adCYWzVJQKZXsqSTg3ia12tmdibiaoTZTEjBqfVvmfODz1KpD73pKy4h1W0fAXj62kxGbQA/132, createdBy=d2132500095, createdName=ms5768352621950538, createdTime=Sun Nov 19 07:43:00 CST 2017, time=2017-11-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1662776, encodeId=efb21662e76e9, content=<a href='/topic/show?id=8efc540637b' target=_blank style='color:#2F92EE;'>#成纤维细胞生长因子23#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=43, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=54063, encryptionId=8efc540637b, topicName=成纤维细胞生长因子23)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=d84725492890, createdName=ms5906905816781247, createdTime=Tue Mar 27 23:43:00 CST 2018, time=2018-03-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1777684, encodeId=771a1e77684f0, content=<a href='/topic/show?id=eb9610265ed' target=_blank style='color:#2F92EE;'>#JCEM#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=47, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10265, encryptionId=eb9610265ed, topicName=JCEM)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=2a4439169927, createdName=smallant2015, createdTime=Thu Mar 22 00:43:00 CST 2018, time=2018-03-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1307068, encodeId=2aee130e068ee, content=<a href='/topic/show?id=6dab540565f' target=_blank style='color:#2F92EE;'>#成纤维细胞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=51, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=54056, encryptionId=6dab540565f, topicName=成纤维细胞)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=5d70341, createdName=zhishijing, createdTime=Thu Nov 02 11:43:00 CST 2017, time=2017-11-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1462751, encodeId=8c3c1462e514a, content=<a href='/topic/show?id=fbbce726228' target=_blank style='color:#2F92EE;'>#纤维细胞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=77262, encryptionId=fbbce726228, topicName=纤维细胞)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=6c516518840, createdName=marongnuan, createdTime=Thu Nov 02 11:43:00 CST 2017, time=2017-11-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1517974, encodeId=7b91151e974d2, content=<a href='/topic/show?id=aa2269613cd' target=_blank style='color:#2F92EE;'>#生长因子#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=69613, encryptionId=aa2269613cd, topicName=生长因子)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=3df311117154, createdName=12499e01m50暂无昵称, createdTime=Thu Nov 02 11:43:00 CST 2017, time=2017-11-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1544477, encodeId=972715444e766, content=<a href='/topic/show?id=ac3d6549e75' target=_blank style='color:#2F92EE;'>#浓度#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=65497, encryptionId=ac3d6549e75, topicName=浓度)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=16b213663040, createdName=12498974m55暂无昵称, createdTime=Thu Nov 02 11:43:00 CST 2017, time=2017-11-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1569011, encodeId=e23f1569011fa, content=<a href='/topic/show?id=5b9ee7968f5' target=_blank style='color:#2F92EE;'>#细胞生长#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=77968, encryptionId=5b9ee7968f5, topicName=细胞生长)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=75d615484024, createdName=wwzzly, createdTime=Thu Nov 02 11:43:00 CST 2017, time=2017-11-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=258005, encodeId=09fb25800570, content=内容很好.收藏了.以后用的到, beContent=null, objectType=article, channel=null, level=null, likeNumber=77, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zMoyicyo6ia9f4IuLQAwZoxD6Hx4ibd5CMcOCYhStY6oDibbKK6O2X8iaicldO5ib8j1iapOIobIKCGiczU2A/0, createdBy=56251941490, createdName=虈亣靌, createdTime=Thu Nov 02 08:12:28 CST 2017, time=2017-11-02, status=1, ipAttribution=)]
    2018-03-22 smallant2015
  5. [GetPortalCommentsPageByObjectIdResponse(id=2063066, encodeId=e6a620630667e, content=<a href='/topic/show?id=14fb10264d7' target=_blank style='color:#2F92EE;'>#JCE#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10264, encryptionId=14fb10264d7, topicName=JCE)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e656479, createdName=achengzhao, createdTime=Thu Sep 27 16:43:00 CST 2018, time=2018-09-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1956606, encodeId=544219566062b, content=<a href='/topic/show?id=e15ce3940f' target=_blank style='color:#2F92EE;'>#FGF23#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=52, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7394, encryptionId=e15ce3940f, topicName=FGF23)], attachment=null, authenticateStatus=null, 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target=_blank style='color:#2F92EE;'>#JCEM#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=47, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10265, encryptionId=eb9610265ed, topicName=JCEM)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=2a4439169927, createdName=smallant2015, createdTime=Thu Mar 22 00:43:00 CST 2018, time=2018-03-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1307068, encodeId=2aee130e068ee, content=<a href='/topic/show?id=6dab540565f' target=_blank style='color:#2F92EE;'>#成纤维细胞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=51, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=54056, encryptionId=6dab540565f, topicName=成纤维细胞)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=5d70341, createdName=zhishijing, createdTime=Thu Nov 02 11:43:00 CST 2017, time=2017-11-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1462751, encodeId=8c3c1462e514a, content=<a href='/topic/show?id=fbbce726228' target=_blank style='color:#2F92EE;'>#纤维细胞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=77262, encryptionId=fbbce726228, topicName=纤维细胞)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=6c516518840, createdName=marongnuan, createdTime=Thu Nov 02 11:43:00 CST 2017, time=2017-11-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1517974, encodeId=7b91151e974d2, content=<a href='/topic/show?id=aa2269613cd' target=_blank style='color:#2F92EE;'>#生长因子#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=69613, encryptionId=aa2269613cd, topicName=生长因子)], attachment=null, authenticateStatus=null, createdAvatar=null, 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topicList=[TopicDto(id=77968, encryptionId=5b9ee7968f5, topicName=细胞生长)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=75d615484024, createdName=wwzzly, createdTime=Thu Nov 02 11:43:00 CST 2017, time=2017-11-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=258005, encodeId=09fb25800570, content=内容很好.收藏了.以后用的到, beContent=null, objectType=article, channel=null, level=null, likeNumber=77, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zMoyicyo6ia9f4IuLQAwZoxD6Hx4ibd5CMcOCYhStY6oDibbKK6O2X8iaicldO5ib8j1iapOIobIKCGiczU2A/0, createdBy=56251941490, createdName=虈亣靌, createdTime=Thu Nov 02 08:12:28 CST 2017, time=2017-11-02, status=1, ipAttribution=)]
  6. [GetPortalCommentsPageByObjectIdResponse(id=2063066, encodeId=e6a620630667e, content=<a href='/topic/show?id=14fb10264d7' target=_blank style='color:#2F92EE;'>#JCE#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10264, encryptionId=14fb10264d7, topicName=JCE)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e656479, createdName=achengzhao, createdTime=Thu Sep 27 16:43:00 CST 2018, time=2018-09-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1956606, encodeId=544219566062b, content=<a href='/topic/show?id=e15ce3940f' target=_blank style='color:#2F92EE;'>#FGF23#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=52, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7394, encryptionId=e15ce3940f, topicName=FGF23)], attachment=null, authenticateStatus=null, 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target=_blank style='color:#2F92EE;'>#JCEM#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=47, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10265, encryptionId=eb9610265ed, topicName=JCEM)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=2a4439169927, createdName=smallant2015, createdTime=Thu Mar 22 00:43:00 CST 2018, time=2018-03-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1307068, encodeId=2aee130e068ee, content=<a href='/topic/show?id=6dab540565f' target=_blank style='color:#2F92EE;'>#成纤维细胞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=51, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=54056, encryptionId=6dab540565f, topicName=成纤维细胞)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=5d70341, createdName=zhishijing, createdTime=Thu Nov 02 11:43:00 CST 2017, time=2017-11-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1462751, encodeId=8c3c1462e514a, content=<a href='/topic/show?id=fbbce726228' target=_blank style='color:#2F92EE;'>#纤维细胞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=77262, encryptionId=fbbce726228, topicName=纤维细胞)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=6c516518840, createdName=marongnuan, createdTime=Thu Nov 02 11:43:00 CST 2017, time=2017-11-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1517974, encodeId=7b91151e974d2, content=<a href='/topic/show?id=aa2269613cd' target=_blank style='color:#2F92EE;'>#生长因子#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=69613, encryptionId=aa2269613cd, topicName=生长因子)], attachment=null, authenticateStatus=null, createdAvatar=null, 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topicList=[TopicDto(id=77968, encryptionId=5b9ee7968f5, topicName=细胞生长)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=75d615484024, createdName=wwzzly, createdTime=Thu Nov 02 11:43:00 CST 2017, time=2017-11-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=258005, encodeId=09fb25800570, content=内容很好.收藏了.以后用的到, beContent=null, objectType=article, channel=null, level=null, likeNumber=77, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zMoyicyo6ia9f4IuLQAwZoxD6Hx4ibd5CMcOCYhStY6oDibbKK6O2X8iaicldO5ib8j1iapOIobIKCGiczU2A/0, createdBy=56251941490, createdName=虈亣靌, createdTime=Thu Nov 02 08:12:28 CST 2017, time=2017-11-02, status=1, ipAttribution=)]
  7. 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  8. 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  9. 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  10. 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    2017-11-02 虈亣靌

    内容很好.收藏了.以后用的到

    0