Heart:失代偿性主动脉狭窄的紧急治疗!

2017-06-01 xing.T MedSci原创

在这个多中心队列中,进行eTAVI和eBAV的即刻和30天的死亡率很高,并且eBAV后eTAVI治疗的死亡率也高于预期。随机对照研究的数据需要确定紧急eTAVI在当前设备的三级医疗中心中的作用。

由于介入治疗和支持疗法的最新进展,对急性和严重主动脉瓣狭窄失代偿患者的最佳治疗尚不清楚。近日,在心脏病领域权威杂志Heart上发表了一篇研究文章,研究人员旨在评估紧急经导管主动脉瓣植入术(eTAVI)与紧急球囊主动脉瓣成形术(eBAV)后TAVI的早期疗效结局。

紧急疾病被定义为:需要儿茶酚胺治疗的心源性休克、严重急性呼吸困难(NYHA IV级)、心脏复苏或机械通气。研究人员根据瓣膜学术研究协会2(VARC-2)的标准进行数据收集。

在五个德国中心中,23例患者(Logistic EuroSCORE为37.7%±18.1)接受了eTAVI 治疗,118例(Logistic EuroSCORE为35.3%±20.8)接受了eBAV治疗。在eTAVI治疗组,即刻手术死亡率为8.7%,相比于eBAV治疗组为20.3%(P=0.19)。30天之后,eTAVI组心血管死亡率为23.8%,而eBAV组为33%(P=0.40)。调整了潜在混杂因素的分析并没有提供组间差异的证据。值得注意的是,eBAV后选择进行TAVI的患者(n=32,Logistic EuroSCORE为25.9%±13.9)即刻手术死亡率为9.4%,以及30天心血管疾病死亡率为15.6%。大血管并发症在eTAVI治疗后发生率明显升高(P=0.01),卒中也是同样的(P=0.01)。

在这个多中心队列中,进行eTAVI和eBAV的即刻和30天的死亡率很高,并且eBAV后eTAVI治疗的死亡率也高于预期。随机对照研究的数据需要确定紧急eTAVI在当前设备的三级医疗中心中的作用。

原始出处:

Dario Bongiovanni,et al. Emergency treatment of decompensated aortic stenosis. Heart. 2017. http://dx.doi.org/10.1136/heartjnl-2016-311037

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    2017-06-03 zhaojie88
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    2017-06-03 slcumt
  7. [GetPortalCommentsPageByObjectIdResponse(id=1315151, encodeId=33b3131515156, content=<a href='/topic/show?id=c115231e9dc' target=_blank style='color:#2F92EE;'>#主动脉狭窄#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=23179, encryptionId=c115231e9dc, topicName=主动脉狭窄)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=2f8f432, createdName=longerg, createdTime=Sat Jun 03 01:55:00 CST 2017, time=2017-06-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1356299, encodeId=1c8113562996c, content=<a href='/topic/show?id=b0702e84b9' target=_blank style='color:#2F92EE;'>#ART#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2784, encryptionId=b0702e84b9, topicName=ART)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=zhaojie88, createdTime=Sat Jun 03 01:55:00 CST 2017, time=2017-06-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1415141, encodeId=759c14151415e, content=<a href='/topic/show?id=04812314540' target=_blank style='color:#2F92EE;'>#主动脉#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=22, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=23145, encryptionId=04812314540, topicName=主动脉)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=77603112682, createdName=circumcision, createdTime=Sat Jun 03 01:55:00 CST 2017, time=2017-06-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1496871, encodeId=ed8d14968e1e4, content=<a href='/topic/show?id=217b33259df' target=_blank style='color:#2F92EE;'>#动脉狭窄#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=33259, encryptionId=217b33259df, topicName=动脉狭窄)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=b4ae9287436, createdName=piaojinhua, createdTime=Sat Jun 03 01:55:00 CST 2017, time=2017-06-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1523205, encodeId=4d2e152320562, content=<a href='/topic/show?id=1a1de7006b0' target=_blank style='color:#2F92EE;'>#紧急#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=20, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=77006, encryptionId=1a1de7006b0, topicName=紧急)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=b88211514540, createdName=guguangxiang, createdTime=Sat Jun 03 01:55:00 CST 2017, time=2017-06-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1562544, encodeId=675f1562544f1, content=<a href='/topic/show?id=f69d864413' target=_blank style='color:#2F92EE;'>#HEART#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=21, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=8644, encryptionId=f69d864413, topicName=HEART)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=80d715270048, createdName=slcumt, createdTime=Sat Jun 03 01:55:00 CST 2017, time=2017-06-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=205510, encodeId=8e9b2055103f, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib2JlGvwpAibiaovVhfA9DbO7X7JLGGjM4Cic6oMgxLdnuS9piaP9cnG2OwIbkzHvX0qzS1boibyYNqR5vHZu7HQs5EIB/0, createdBy=298d1398341, createdName=lou.minghong, createdTime=Fri Jun 02 08:03:06 CST 2017, time=2017-06-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=205241, encodeId=a50f205241f6, content=非常好的文章,学习了。, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=60791943465, createdName=1e0f8808m18(暂无匿称), createdTime=Thu Jun 01 13:03:27 CST 2017, time=2017-06-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=205207, encodeId=444f20520e4c, content=学习一下谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=54, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzaiabIFicf63hKvVMjL6aJlx4yX4UcXmzX9DyibCRcicq0QtCRWMaQKh8MYjE1D3EKUBopgiaGWYuqbeR/0, createdBy=0c2b1999806, createdName=三生有幸9135, createdTime=Thu Jun 01 12:07:32 CST 2017, time=2017-06-01, status=1, ipAttribution=)]
    2017-06-02 lou.minghong

    学习了

    0

  8. [GetPortalCommentsPageByObjectIdResponse(id=1315151, encodeId=33b3131515156, content=<a href='/topic/show?id=c115231e9dc' target=_blank style='color:#2F92EE;'>#主动脉狭窄#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=23179, encryptionId=c115231e9dc, topicName=主动脉狭窄)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=2f8f432, createdName=longerg, createdTime=Sat Jun 03 01:55:00 CST 2017, time=2017-06-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1356299, encodeId=1c8113562996c, content=<a href='/topic/show?id=b0702e84b9' target=_blank style='color:#2F92EE;'>#ART#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2784, encryptionId=b0702e84b9, topicName=ART)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=zhaojie88, createdTime=Sat Jun 03 01:55:00 CST 2017, time=2017-06-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1415141, encodeId=759c14151415e, content=<a href='/topic/show?id=04812314540' target=_blank style='color:#2F92EE;'>#主动脉#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=22, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=23145, encryptionId=04812314540, topicName=主动脉)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=77603112682, createdName=circumcision, createdTime=Sat Jun 03 01:55:00 CST 2017, time=2017-06-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1496871, encodeId=ed8d14968e1e4, content=<a href='/topic/show?id=217b33259df' target=_blank style='color:#2F92EE;'>#动脉狭窄#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=33259, encryptionId=217b33259df, topicName=动脉狭窄)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=b4ae9287436, createdName=piaojinhua, createdTime=Sat Jun 03 01:55:00 CST 2017, time=2017-06-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1523205, encodeId=4d2e152320562, content=<a href='/topic/show?id=1a1de7006b0' target=_blank style='color:#2F92EE;'>#紧急#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=20, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=77006, encryptionId=1a1de7006b0, topicName=紧急)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=b88211514540, createdName=guguangxiang, createdTime=Sat Jun 03 01:55:00 CST 2017, time=2017-06-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1562544, encodeId=675f1562544f1, content=<a href='/topic/show?id=f69d864413' target=_blank style='color:#2F92EE;'>#HEART#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=21, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=8644, encryptionId=f69d864413, topicName=HEART)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=80d715270048, createdName=slcumt, createdTime=Sat Jun 03 01:55:00 CST 2017, time=2017-06-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=205510, encodeId=8e9b2055103f, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib2JlGvwpAibiaovVhfA9DbO7X7JLGGjM4Cic6oMgxLdnuS9piaP9cnG2OwIbkzHvX0qzS1boibyYNqR5vHZu7HQs5EIB/0, createdBy=298d1398341, createdName=lou.minghong, createdTime=Fri Jun 02 08:03:06 CST 2017, time=2017-06-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=205241, encodeId=a50f205241f6, content=非常好的文章,学习了。, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=60791943465, createdName=1e0f8808m18(暂无匿称), createdTime=Thu Jun 01 13:03:27 CST 2017, time=2017-06-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=205207, encodeId=444f20520e4c, content=学习一下谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=54, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzaiabIFicf63hKvVMjL6aJlx4yX4UcXmzX9DyibCRcicq0QtCRWMaQKh8MYjE1D3EKUBopgiaGWYuqbeR/0, createdBy=0c2b1999806, createdName=三生有幸9135, createdTime=Thu Jun 01 12:07:32 CST 2017, time=2017-06-01, status=1, ipAttribution=)]
    2017-06-01 1e0f8808m18(暂无匿称)

    非常好的文章,学习了。

    0

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    2017-06-01 三生有幸9135

    学习一下谢谢分享

    0

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AHA2012:治疗急性心肾综合征超滤治疗不如药物治疗

  美国心脏协会(AHA)年会上公布的一项大型多中心随机研究显示,在利尿剂治疗有效的合并心肾综合征的急性失代偿性心力衰竭住院患者中,机械性静脉-静脉超滤的疗效不如药物治疗。   这项急性失代偿性心力衰竭心肾抢救研究(CARRESS-HF)由明尼阿波里斯市亨内平县医疗中心的Bradley A. Bart博士及其同事进行,共纳入188例利尿剂治疗有效的患者。患者被随机分成2组,一组接受阶梯式药物治疗

Crit Care:体外膜肺氧合治疗急性失代偿性心力衰竭效果如何?

在选取的105例接受体外膜肺氧合治疗急性失代偿性心力衰竭患者中,其1年生存率为42%,但在体外膜肺氧合前序贯器官衰竭评分小于11的患者中生存率更好。体外膜肺氧合对于急性失代偿性心力衰竭患者应给予考虑,但是接受治疗的时机是至关重要的。