Neurology:脑小血管病变患者血脑屏障渗漏更为普遍

2016-12-30 xing.T MedSci原创

由此可见,研究者证明了脑小血管病患者微小血脑屏障渗漏体积比对照者要大。并且这些变化在NAWM、WMH和CGM均存在差异,表明脑小血管病累及全脑的特性。

血脑屏障功能障碍可能发生在正常老化过程中,但也可能在脑小血管病的病理生理过程中发挥着举足轻重的作用。近日,神经病学领域权威取杂志Neurology上发表了一篇研究文章,研究人员通过使用动态对比增强(DCE)–MRI来检测脑小血管病和年龄、性别匹配的对照者血脑屏障渗漏的速度和空间范围,以此来将脑小血管病相关的渗漏从老化相关的渗漏中识别出来。

研究人员对80名临床上明显变化的脑小血管病患者和40名年龄和性别匹配的对照者进行了脑结构MRI及DCE-MRI检查。研究人员采用Patlak药代动力学模型计算出了渗漏率;使用噪声校正直方图分析计算的平均渗漏率和相对渗漏量。研究人员比较了脑小血管病患者与对照者之间正常脑白质(NAWM)、白质高信号(WMH)、灰质(CGM)和深部灰质这些部位渗漏率和渗漏量的情况。


调整了年龄、性别和心血管危险因素的多变量线性回归分析表明脑小血管病患者NAWM、WMH和CGM的泄漏量明显比对照组较大。但是研究人员发现在任何组织区域的泄漏率无显著差异。

由此可见,研究者证明了脑小血管病患者微小血脑屏障渗漏体积比对照者要大,并且这些变化在NAWM、WMH和CGM均存在差异,表明了脑小血管病累及全脑的特性。

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    2017-06-21 yinhl1978
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    2016-12-30 inter158

    通过使用动态对比增强(DCE)–MRI来检测脑小血管病和年龄、性别匹配的对照者血脑屏障渗漏的速度和空间范围

    0

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    2016-12-30 1e128d2fm65(暂无匿称)

    好文章

    0

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