Nat Rev Gastro Hepat:炎症性肠炎的当前和新兴治疗靶点

2017-05-09 zhangfan MedSci原创

通过全面的概述目前和未来的治疗炎症性肠炎的方法,对治疗方法的作用机制及其临床治疗炎症性肠炎的潜在机制进行讨论将有助于人类早日攻克该疾病

治疗方法进展导致炎症性肠炎(IBD)患者的临床治疗模式的转变。免疫抑制剂(如硫唑嘌呤)和生物制剂(如TNF抑制剂)的应用显著减少了糖皮质激素治疗的使用。

未来α4β7整合素阻断剂Vedolizumab可能会作为临床IBD的治疗手段。此外各种新的细胞因子抑制剂(例如,IL-6和 IL-6受体抑制剂、IL-12和IL-23阻滞剂或Apremilast)、胞因子信号事件调节剂(JAK抑制剂或SMAD7阻断剂)、转录因子抑制剂(例如GATA3 或 RORγt)、抗粘附和抗T细胞活化和迁移策略(例如,β7整合素,1-磷酸鞘氨醇受体和兔黏膜地址素细胞黏附分子1抑制剂,调节性T细胞和干细胞治疗)都有望成为新的抗炎症性肠炎的手段。

通过全面的概述目前和未来的治疗炎症性肠炎的方法,对治疗方法的作用机制及其临床治疗炎症性肠炎的潜在机制进行讨论将有助于人类早日攻克该疾病。

原文出处:

Markus F. Neurath et al. Current and emerging therapeutic targets for IBD. Nat Rev Gastro Hepat. Feb 1 2017

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    2017-12-23 许安
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    2017-10-23 liye789132251
  4. 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attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6KcicAVC1MwuK9CDibOwszLoEBg36ZXqzB5NDasNV9GTfFDmBicM1V8hUS4OtTicG3IiaFIKq4wqD23LUxORRJXqjVs/0, createdBy=00e81647535, createdName=I come, createdTime=Mon Jun 12 00:08:38 CST 2017, time=2017-06-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=197627, encodeId=957919e62727, content=学习了,各个系统都可见一些难治性炎症性疾病!, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/04/29/6902c9c65fe215fc96c6d153c8590e95.JPG, createdBy=f9312054548, createdName=138****1711, createdTime=Sat May 13 17:17:15 CST 2017, time=2017-05-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1426726, encodeId=e3001426e26a2, content=<a href='/topic/show?id=221d685172' target=_blank 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GetPortalCommentsPageByObjectIdResponse(id=195860, encodeId=e14b1958601a, content=学习了,希望早日可以攻克, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6KcicAVC1MwuCkPCv9CVFBmWOibyBArQwSeQLxvxz9OaumlaSUZjfCWTxbXduhuG2xCJUPs1nB9nd4gxZknH7IZj/0, createdBy=52281985209, createdName=damiao93, createdTime=Tue May 09 14:55:47 CST 2017, time=2017-05-09, status=1, ipAttribution=)]
  5. 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encryptionId=18ae64e21d3, topicName=治疗靶点)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=80c5136, createdName=drj2003, createdTime=Wed Dec 06 08:03:00 CST 2017, time=2017-12-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=211253, encodeId=657c211253fb, content=学习了谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=69, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib06iaV3D9Tg5KwlM29ic8TDJMJOiarryMIZZhTjXxyRT9lffSWpWWcWojnL7ibJwcOn99ayict8FJ9ICYmNh9swD6R4E/0, createdBy=196f1683049, createdName=收获你的美, createdTime=Thu Jun 15 22:24:57 CST 2017, time=2017-06-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=209571, encodeId=ac072095e116, content=学习了谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[], 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style='color:#2F92EE;'>#EPA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=6851, encryptionId=221d685172, topicName=EPA)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=4a9b4077760, createdName=gwc384, createdTime=Thu May 11 02:03:00 CST 2017, time=2017-05-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1547041, encodeId=155d154e041f1, content=<a href='/topic/show?id=4ef26e01766' target=_blank style='color:#2F92EE;'>#炎症性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=67017, encryptionId=4ef26e01766, topicName=炎症性)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=21015, createdName=heli0118, createdTime=Thu May 11 02:03:00 CST 2017, time=2017-05-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=195860, encodeId=e14b1958601a, content=学习了,希望早日可以攻克, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6KcicAVC1MwuCkPCv9CVFBmWOibyBArQwSeQLxvxz9OaumlaSUZjfCWTxbXduhuG2xCJUPs1nB9nd4gxZknH7IZj/0, createdBy=52281985209, createdName=damiao93, createdTime=Tue May 09 14:55:47 CST 2017, time=2017-05-09, status=1, ipAttribution=)]
    2017-06-15 收获你的美

    学习了谢谢分享

    0

  6. 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style='color:#2F92EE;'>#EPA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=6851, encryptionId=221d685172, topicName=EPA)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=4a9b4077760, createdName=gwc384, createdTime=Thu May 11 02:03:00 CST 2017, time=2017-05-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1547041, encodeId=155d154e041f1, content=<a href='/topic/show?id=4ef26e01766' target=_blank style='color:#2F92EE;'>#炎症性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=67017, encryptionId=4ef26e01766, topicName=炎症性)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=21015, createdName=heli0118, createdTime=Thu May 11 02:03:00 CST 2017, time=2017-05-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=195860, encodeId=e14b1958601a, content=学习了,希望早日可以攻克, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6KcicAVC1MwuCkPCv9CVFBmWOibyBArQwSeQLxvxz9OaumlaSUZjfCWTxbXduhuG2xCJUPs1nB9nd4gxZknH7IZj/0, createdBy=52281985209, createdName=damiao93, createdTime=Tue May 09 14:55:47 CST 2017, time=2017-05-09, status=1, ipAttribution=)]
    2017-06-12 I come

    学习了谢谢分享

    0

  7. 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    2017-05-13 138****1711

    学习了,各个系统都可见一些难治性炎症性疾病!

    0

  8. 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GetPortalCommentsPageByObjectIdResponse(id=195860, encodeId=e14b1958601a, content=学习了,希望早日可以攻克, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6KcicAVC1MwuCkPCv9CVFBmWOibyBArQwSeQLxvxz9OaumlaSUZjfCWTxbXduhuG2xCJUPs1nB9nd4gxZknH7IZj/0, createdBy=52281985209, createdName=damiao93, createdTime=Tue May 09 14:55:47 CST 2017, time=2017-05-09, status=1, ipAttribution=)]
    2017-05-11 gwc384
  9. 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  10. 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    2017-05-09 damiao93

    学习了,希望早日可以攻克

    0

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2012年5月18日,美国国立卫生研究院国家癌症研究所Frank Gonzalez 等研究人员发表了一篇题为Pregnane X receptor as a target for treatment of inflammatory bowel disorders的科研论文,研究表明孕烷X受体很可能成为一种治疗炎症性肠炎的新药,该研究发表在最新一期的Trends  in &nbs

Inflamm Bowel Dis:正念疗法可作为炎症性肠炎患者的有效干预措施

原始出处:Motzer RJ, Escudier B, et al. Nivolumab versus Everolimus in Advanced Renal-Cell Carcinoma. N Engl J Med. 2015 Nov 5;373(19):1803-13. doi: 10.1056/NEJMoa1510665.

Am J Gastroenterol:加拿大小儿炎症性肠炎流行趋势

加拿大是世界上儿童炎症性肠炎发病率最高的国家之一,近年来炎症性肠炎患病率显着增加,特别是0至5岁幼儿发病率增长较快

Gut:口服VS. 静脉注射铁补充治疗可明显改变IBD患者的肠道菌群及代谢

铁缺乏症是IBD患者的一个常见并发症,口服补充铁可恶化IBD患者的症状。我们进行了此项非盲临床试验以对比口服(PO)和静脉注射(IV)铁补充疗法(IRT)的效果。

CGH:炎症性肠炎会影响试管婴儿成功率吗?

炎症性肠炎(IBD)会对育龄期女性造成多个方面的困扰,近期OzaSS等人进行了一项研究,关注炎症性肠炎(IBD)对女性试管婴儿孕育情况的影响。