赛诺菲巴斯德公司开始研发寨卡病毒疫苗

2016-02-06 MedSci MedSci原创

图片来源:magneticmediatv.com制药公司赛诺菲巴斯德(Sanofi Pasteur)近日表示,他们公司已经开始研究并且开发新型疫苗用以应对Zika病毒(寨卡病毒)。赛诺菲早在周二宣布,当世界卫生组织宣布这种蚊传播病毒在全球爆发性的疫情后,疫苗的开发就应该立马开始,而在美国寨卡病毒和婴幼儿出生缺陷直接相关。目前针对寨卡病毒并没有有效的疗法和疫苗,而寨卡病毒和登革热属于同一个病毒家族,

图片来源:magneticmediatv.com

制药公司赛诺菲巴斯德(Sanofi Pasteur)近日表示,他们公司已经开始研究并且开发新型疫苗用以应对Zika病毒(寨卡病毒)。

赛诺菲早在周二宣布,当世界卫生组织宣布这种蚊传播病毒在全球爆发性的疫情后,疫苗的开发就应该立马开始,而在美国寨卡病毒和婴幼儿出生缺陷直接相关。

目前针对寨卡病毒并没有有效的疗法和疫苗,而寨卡病毒和登革热属于同一个病毒家族,如今赛诺菲公司开发的登革热疫苗首次获得许可,并于去年在巴西也获得了认可。

位于法国的赛诺菲公司在周二的一份声明中表示,在经历了登革热疫苗的开发后,许多经验都可以帮助理解寨卡病毒的扩散,从而为开发潜在的候选疫苗来用于抵御寨卡病毒的感染和传播提供思路。

关于寨卡病毒:

寨卡病毒 (ZIKV)属于黄病毒科病毒科,黄病毒属,可以通过伊蚊传播给人类。和黄病毒科内的其它病毒一样,寨卡病毒有包膜和二十面体的蛋白衣壳,为正链RNA病毒。与它最密切相关的病毒是Spondweni病毒。在人类中,它会导致称为兹卡的轻微疾病。兹卡疾病,或又称为兹卡发热,自20世纪50年代一直仅仅发生在赤道附近非洲和亚洲的狭长地带。

寨卡病毒可以由白天活跃蚊子传播。现已知多种伊蚊都可以传播这种病毒。研究表明,寨卡病毒在伊蚊体内的外在潜伏期约为10天。该病毒的脊椎动物宿主主要是猴子和人类。目前来说,该病毒的发病机制还并不明确。科学家的假设是,zika病毒开始时会感染树突细胞近核的部位,随后扩散到淋巴结和血液中。一般的,黄病毒科病毒通常在细胞质中复制,但zika病毒的抗原已被发现被感染的细胞核中。

这种病毒引起的症状就像是登革热的温和形式 。感染该病毒的常见症状包括,轻微头痛、斑丘疹,发热、全身乏力、红眼病和关节痛。开始时,会有轻度头痛,并逐渐发展到斑丘疹、发烧、背部疼痛。两天之内,皮疹消退,并在三天内,发烧结束,但皮疹依然存在。至今仍然没有特效疫苗和治疗药物。

进展情况:

据哥伦比亚卫生部门1月30日通报,目前该国已累计有逾两万人感染寨卡病毒,其中包括2100多名孕妇感染者。

据当地媒体报道,哥伦比亚国家卫生研究院1月30日发布公报称,该国已有20297人确诊感染寨卡病毒,其中包括2116名孕妇,但尚未发现死亡病例或新生儿小头症患者。此前,世界卫生组织称,寨卡病毒的出现与某些地区的新生儿小头症及格林-巴利综合征病例数量激增可能存在关联。

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    2016-02-08 lqvr
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    2016-02-07 1de3b290m83(暂无匿称)

    好好研究

    0