Metabolism:2型糖尿病患者apoC-III、内皮依赖性血管舒张功能与周围神经病变有啥关系?

2017-06-25 xing.T MedSci原创

由此可见,DPN患者血浆中apoC-III水平较高。血脂与大血管并发症除了已知的相关性外,该研究还提示它与DPN有关。调节apoC-III代谢是否是2型糖尿病患者管理血脂异常和微血管并发症的一个重要的新的治疗方法还有待在今后的机理和临床研究予以证明。

糖尿病周围神经病变(DPN)是2型糖尿病的常见并发症。除了高血糖外,其发病机制还不清楚。载脂蛋白CIII(apoC-III)与甘油三酯代谢相关,是心血管疾病的危险因素。它在DPN中的作用尚未明确。近日,代谢性疾病领域权威杂志Metabolism-Clinical and Experimental上发表了一篇研究文章,研究人员探究了apoC-III、内皮功能和DPN之间的相关性。

在2型糖尿病患者中,研究人员收集了人体数据、空腹血液以及尿液来测定生化指标和尿白蛋白/肌酐(uACR)。血管内皮功能的评估是由激光多普勒/成像来实现。当双脚单丝(≤8-10分)或神经振动感觉测定器测试≥25V存在异常就考虑DPN。研究人员采用ELISA法测定血浆apoC-III水平。

研究人员测定了1981名受试者的单丝和神经振动感觉测定器读数,这些受试者的平均年龄为57.4±10.8岁。DPN患病率为10.8%(n=214)。DPN患者较无DPN的患者,年龄显著较大(P<0.0001),2型糖尿病病程较长(P<0.0001),有较大的BMI(P=0.006),较高的血糖(P=0.015)和糖化血红蛋白(P<0.0001)以及收缩压(SBP)(P<0.0001)水平,较低的eGFR (P<0.0001),较高的尿ACR(P<0.0001),较差的内皮依赖性和内皮非依赖性血管舒张功能(P<0.0001),较高的VCAM-1水平(P<0.0001)以及较高的apoC-III水平[285.3(195.2-405.6)vs. 242.9(165-344)μg/ml]。调整后,对数变换的apoC-III,仍然与DPN的存在独立相关(B=0.965,SE=0.397,P=0.015)。

由此可见,DPN患者血浆中apoC-III水平较高。血脂与大血管并发症除了已知的相关性外,该研究还提示它与DPN有关。调节apoC-III代谢是否是2型糖尿病患者管理血脂异常和微血管并发症的一个重要的新的治疗方法还有待在今后的机理和临床研究予以证明。

原始出处:

Sharon Li Ting Pek,et al. Association of apolipoprotein-CIII (apoC-III), endothelium-dependent vasodilation and peripheral neuropathy in a multi-ethnic population with type 2 diabetes. Metabolism-Clinical and Experimental.2017. http://dx.doi.org/10.1016/j.metabol.2017.03.016

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    2017-10-14 yahu
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    2017-09-07 一闲
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    2018-03-06 juliusluan78
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topicName=Meta)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d8f4110, createdName=guojianrong, createdTime=Sat Feb 03 13:33:00 CST 2018, time=2018-02-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1997479, encodeId=a878199e47946, content=<a href='/topic/show?id=855e89e724b' target=_blank style='color:#2F92EE;'>#血管舒张#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=51, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=89772, encryptionId=855e89e724b, topicName=血管舒张)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=325a197, createdName=amyloid, createdTime=Fri Aug 25 13:33:00 CST 2017, time=2017-08-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1748249, encodeId=22331e48249d9, content=<a href='/topic/show?id=15b33952464' target=_blank style='color:#2F92EE;'>#周围神经#</a>, beContent=null, objectType=article, channel=null, level=null, 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replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=76718, encryptionId=935fe6718e3, topicName=糖尿病患者)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a38f7243741, createdName=xue8604, createdTime=Tue Jun 27 05:33:00 CST 2017, time=2017-06-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1383310, encodeId=20ab138331034, content=<a href='/topic/show?id=196a1101f7' target=_blank style='color:#2F92EE;'>#2型糖尿病患者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=1101, encryptionId=196a1101f7, topicName=2型糖尿病患者)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=ec19483, createdName=aids213, createdTime=Tue Jun 27 05:33:00 CST 2017, time=2017-06-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1597971, encodeId=0cc2159e971dd, content=<a href='/topic/show?id=6c6f1e62c5' target=_blank style='color:#2F92EE;'>#ABO#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=21, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=1762, encryptionId=6c6f1e62c5, topicName=ABO)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=b6c918580135, createdName=闆锋旦, createdTime=Tue Jun 27 05:33:00 CST 2017, time=2017-06-27, status=1, ipAttribution=)]
    2018-02-03 guojianrong
  5. 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style='color:#2F92EE;'>#ABO#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=21, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=1762, encryptionId=6c6f1e62c5, topicName=ABO)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=b6c918580135, createdName=闆锋旦, createdTime=Tue Jun 27 05:33:00 CST 2017, time=2017-06-27, status=1, ipAttribution=)]
  6. 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  7. 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likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=39524, encryptionId=15b33952464, topicName=周围神经)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f00136108751, createdName=Smile2692, createdTime=Wed Apr 18 06:33:00 CST 2018, time=2018-04-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=216031, encodeId=4df92160316b, content=继续学习中谢谢, beContent=null, objectType=article, channel=null, level=null, likeNumber=51, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c0a61971598, createdName=往日如昨, createdTime=Tue Jun 27 17:04:14 CST 2017, time=2017-06-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1474224, encodeId=31e714e42240a, content=<a href='/topic/show?id=935fe6718e3' target=_blank style='color:#2F92EE;'>#糖尿病患者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=76718, encryptionId=935fe6718e3, topicName=糖尿病患者)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a38f7243741, createdName=xue8604, createdTime=Tue Jun 27 05:33:00 CST 2017, time=2017-06-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1383310, encodeId=20ab138331034, content=<a href='/topic/show?id=196a1101f7' target=_blank style='color:#2F92EE;'>#2型糖尿病患者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=1101, encryptionId=196a1101f7, topicName=2型糖尿病患者)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=ec19483, createdName=aids213, createdTime=Tue Jun 27 05:33:00 CST 2017, time=2017-06-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1597971, encodeId=0cc2159e971dd, content=<a href='/topic/show?id=6c6f1e62c5' target=_blank style='color:#2F92EE;'>#ABO#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=21, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=1762, encryptionId=6c6f1e62c5, topicName=ABO)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=b6c918580135, createdName=闆锋旦, createdTime=Tue Jun 27 05:33:00 CST 2017, time=2017-06-27, status=1, ipAttribution=)]
    2017-06-27 往日如昨

    继续学习中谢谢

    0

  8. 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  9. 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    2017-06-27 闆锋旦

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