MOL METAB :酒精性肝病怎么治?研究发现重要新药线索!

2017-08-22 佚名 medicalxpress

饮酒过多酒精可能会损害肝脏,但调查人员发现可能有助于治疗酒精性肝病的保护性反应措施。 Beth Israel Deaconess医疗中心(BIDMC)的研究人员与宾夕法尼亚大学的同事合作组织的团队也发现,同样的保护措施可能与厌恶酒精有关,因此有助于治疗酒精中毒。

饮酒过多酒精可能会损害肝脏,但调查人员发现可能有助于治疗酒精性肝病的保护性反应措施。 Beth Israel Deaconess医疗中心(BIDMC)的研究人员与宾夕法尼亚大学的同事合作组织的团队也发现,同样的保护措施可能与厌恶酒精有关,因此有助于治疗酒精中毒。

该研究涉及称为成纤维细胞生长因子21(FGF21)的蛋白质,科学家以前发现有助于保护小鼠免受与饮食有关的肝脏毒性。 BIGMC和哈佛医学院内分泌学,糖尿病和代谢部医学教授Eleftheria Maratos-Flier博士说:“研究酒精诱导的肝脏疾病与FGF21之间的关系是下一步要做的。”

在今天在分子代谢中发表的最新研究中,在一小时内酗酒的人们在六小时之内血液中FGF21大幅增加。在小鼠中也观察到类似的结果。另外,在缺乏FGF21的小鼠中,酒精引起比野生型小鼠更多的肝损伤,以及参与肝脏炎症和瘢痕形成的基因的表达增加。

Maratos-Flier说:“我们表明酒精饮用会引起FGF21作为肝脏中的保护性反应,从而降低酒精引起的损伤程度。 “因为人类和老鼠有相似的反应,小鼠可能是进一步研究的良好模型。”

有趣的是,在缺乏FGF21的小鼠中,酒精被正常清除,表明FGF21在急性酒精代谢中不起作用。此外,繁殖过表达FGF21的小鼠比野生型小鼠消耗更少的酒精。当野生型小鼠施用额外的FGF21时,观察到类似的效果。

研究结果表明,FGF21在酒精代谢中具有双重作用。急性地,FGF21对饮酒反应的上升抑制了饮酒。长期而言,肝脏中FGF21表达的上升可以保护肝脏免受损伤。

Maratos-Flier指出:“我们的研究结果可能会鼓励开发模仿FGF21的药物来治疗酒精性肝病,并可能产生酒精反应。

这一研究项目的下一步包括:是否提高FGF21的作用可以帮助限制或逆转小鼠的肝脏损伤,并减少对人体酒精的偏好。

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    2018-08-02 guojianrong
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    2017-12-26 zhaojie88
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    2017-08-22 1e0f8808m18(暂无匿称)

    酒精性肝病.影响人的健康.

    0

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