JCEM:孕妇HbA1c水平与不良分娩结局之间的关系

2020-03-13 MedSci原创 MedSci原创

由此可见,妊娠期正常范围内糖化血红蛋白水平升高是早产、巨大儿和LGA的独立危险因素。减少HbAc1的干预可能有助于预防不良出生结局。

妊娠期较高的血糖水平一直与不良分娩结局的风险增加相关。在正常范围内糖化血红蛋白升高与不良出生结局之间关系的证据十分有限。近日,内分泌和代谢性疾病领域权威杂志Journal of Clinical Endocrinology & Metabolism上发表了一篇研究文章,研究人员旨在探究正常范围内的糖化血红蛋白与不良分娩风险之间的关系。

数据来源于2014年9月至2018年3月期间中国广东省妇幼医院信息系统。该研究共纳入了5658例妊娠期糖化血红蛋白正常的孕妇。该研究的主要结局指标为不良的分娩结局包括早产、巨大儿和大于胎龄儿(LGA)。

在5658名受试者中,早产、巨大儿和LGA的发生率分别为4.6%(261/5658)、3.5%(200/5658)和5.7%(325/5658)。多变量logistic回归模型结果显示孕妇糖化血红蛋白每增加1%,与早产(OR为1.58, 95%CI为1.08-2.31)、巨大儿(OR为1.70,95%CI为1.10-2.64)和LGA (OR为1.38, 95%CI为0.98-1.96)风险增加呈正相关。在妊娠前体重指数(BMI)≤24kg/m²的女性中,妊娠期糖化血红蛋白和早产之间的关系更为明显。

由此可见,妊娠期正常范围内糖化血红蛋白水平升高是早产、巨大儿和LGA的独立危险因素。减少HbAc1的干预可能有助于预防不良出生结局。

原始出处:

Jianing Bi.et al.Association between the maternal normal range HbA1c values and adverse birth outcomes.J Clin Endocrinol Metab.2020.https://doi.org/10.1210/clinem/dgaa127

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    2020-08-01 achengzhao
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    2020-10-16 smallant2015
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    2021-02-06 Smile2680
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    2020-03-15 linlin2312
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