Eur Heart J:达格列净治疗2型糖尿病患者左室肥大

2020-06-24 MedSci原创 MedSci原创

达格列净治疗显著降低了伴有LVH的T2D患者LVM。LVM的降低伴随着收缩压、体重、内脏和SCAT、胰岛素抵抗和hsCRP的降低。LVM的消退提示达格列净可以启动逆重塑和左心室结构的改变。

近日,血管领域权威杂志Eur Heart J上发表了一篇研究文章,研究人员旨在验证达格列净可能使2型糖尿病(T2D)患者左室肥大(LVH)消退的假说。
 
研究人员随机分配66例LVH以及血压(BP)控制良好的T2D患者(平均年龄为67±7岁,男性占38位)接受达格列净10 mg,每天一次或安慰剂,治疗12个月。该研究的主要终点是通过心脏磁共振成像评估的绝对左心室质量(LVM)变化。
 
在意向治疗分析中,达格列净与安慰剂相比显著降低LVM,绝对平均变化为-2.82g [95%置信区间(CI):-5.13至-0.51,P=0.018]。调整基线LVM、基线BP、体重和收缩压变化的其他敏感性分析显示,LVM变化仍保持统计学显著性(平均值变化为-2.92g;95%CI为-5.45至-0.38,P=0.025)。达格列净显著降低了预先设定的次要终点,包括24小时动态收缩压(P=0.012)、夜间收缩压(P=0.017)、体重(P<0.001)、内脏脂肪组织(VAT)(P<0.001)、皮下脂肪组织(SCAT)(P=0.001)、胰岛素抵抗、稳态模型评估的胰岛素抵抗(P=0.017)和高敏C反应蛋白(hsCRP)(P=0.049)。
 
由此可见,达格列净治疗显著降低了伴有LVH的T2D患者LVM。LVM的降低伴随着收缩压、体重、内脏和SCAT、胰岛素抵抗和hsCRP的降低。LVM的消退提示达格列净可以启动逆重塑和左心室结构的改变,这可能是达格列净的心脏保护作用。
 
原始出处:
 
Alexander J M Brown.et al.A randomized controlled trial of dapagliflozin on left ventricular hypertrophy in people with type two diabetes: the DAPA-LVH trial.Eur Heart J.2020.https://doi.org/10.1093/eurheartj/ehaa419

版权声明:
本网站所有内容来源注明为“梅斯医学”或“MedSci原创”的文字、图片和音视频资料,版权均属于梅斯医学所有。非经授权,任何媒体、网站或个人不得转载,授权转载时须注明来源为“梅斯医学”。其它来源的文章系转载文章,或“梅斯号”自媒体发布的文章,仅系出于传递更多信息之目的,本站仅负责审核内容合规,其内容不代表本站立场,本站不负责内容的准确性和版权。如果存在侵权、或不希望被转载的媒体或个人可与我们联系,我们将立即进行删除处理。
在此留言
评论区 (10)
#插入话题
  1. [GetPortalCommentsPageByObjectIdResponse(id=803705, encodeId=db79803e054b, content=我家我妈吃的是香港万宁的中科胰糖安,每次三粒每天一次,午餐后打白天短效胰岛素,晚上睡前打甘精,准备借三伏酷暑之热吃肾力丹,预防高血压肾病和糖尿病肾病的发作, beContent=null, objectType=article, channel=null, level=null, likeNumber=87, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c2531680715, createdName=1de33e15m69(暂无匿称), createdTime=Tue Jul 21 16:26:49 CST 2020, time=2020-07-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1357544, encodeId=76ab135e544a5, content=<a href='/topic/show?id=b0702e84b9' target=_blank style='color:#2F92EE;'>#ART#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2784, encryptionId=b0702e84b9, topicName=ART)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=zhaojie88, createdTime=Fri Jun 26 14:45:11 CST 2020, time=2020-06-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1383633, encodeId=e355138363315, content=<a href='/topic/show?id=196a1101f7' target=_blank style='color:#2F92EE;'>#2型糖尿病患者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=1101, encryptionId=196a1101f7, topicName=2型糖尿病患者)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=ec19483, createdName=aids213, createdTime=Fri Jun 26 14:45:11 CST 2020, time=2020-06-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1474947, encodeId=dbfd14e4947c3, content=<a href='/topic/show?id=935fe6718e3' target=_blank style='color:#2F92EE;'>#糖尿病患者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=21, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=76718, encryptionId=935fe6718e3, topicName=糖尿病患者)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a38f7243741, createdName=xue8604, createdTime=Fri Jun 26 14:45:11 CST 2020, time=2020-06-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1559656, encodeId=e06d1559656a8, content=<a href='/topic/show?id=d86c4802198' target=_blank style='color:#2F92EE;'>#左室肥大#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=48021, encryptionId=d86c4802198, topicName=左室肥大)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=499d15008036, createdName=zgwhgch, createdTime=Fri Jun 26 14:45:11 CST 2020, time=2020-06-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1563325, encodeId=ef1d15633255f, content=<a href='/topic/show?id=f69d864413' target=_blank style='color:#2F92EE;'>#HEART#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=8644, encryptionId=f69d864413, topicName=HEART)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=80d715270048, createdName=slcumt, createdTime=Fri Jun 26 14:45:11 CST 2020, time=2020-06-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1565665, encodeId=4b8f15656654e, content=<a href='/topic/show?id=d86c4802198' target=_blank style='color:#2F92EE;'>#左室肥大#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=48021, encryptionId=d86c4802198, topicName=左室肥大)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=499d15008036, createdName=zgwhgch, createdTime=Fri Jun 26 14:45:11 CST 2020, time=2020-06-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=799710, encodeId=9b26e9971077, content=<a href='/topic/show?id=d90393941be' target=_blank style='color:#2F92EE;'>#达格列净#</a>列净类降糖药物将成为糖尿病治疗的核心药物。, beContent=null, objectType=article, channel=null, level=null, likeNumber=151, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=93941, encryptionId=d90393941be, topicName=达格列净)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220519/c2ab253484ee4527a2d4e9589a4821ac/45de9bf494a54becb2ea4369c9d11e85.jpg, createdBy=7a3710, createdName=lovetcm, createdTime=Thu Jun 25 07:59:03 CST 2020, time=2020-06-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1043190, encodeId=a69f104319050, content=谢谢MedSci提供最新的资讯, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=misszhang, createdTime=Thu Jun 25 02:45:11 CST 2020, time=2020-06-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=799683, encodeId=75b1e9968333, content=<a href='/topic/show?id=d20f1090c2' target=_blank style='color:#2F92EE;'>#2型糖尿病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=145, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=1090, encryptionId=d20f1090c2, topicName=2型糖尿病)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220519/c2ab253484ee4527a2d4e9589a4821ac/45de9bf494a54becb2ea4369c9d11e85.jpg, createdBy=7a3710, createdName=lovetcm, createdTime=Thu Jun 25 00:21:25 CST 2020, time=2020-06-25, status=1, ipAttribution=)]
    2020-07-21 1de33e15m69(暂无匿称)

    我家我妈吃的是香港万宁的中科胰糖安,每次三粒每天一次,午餐后打白天短效胰岛素,晚上睡前打甘精,准备借三伏酷暑之热吃肾力丹,预防高血压肾病和糖尿病肾病的发作

    0

  2. [GetPortalCommentsPageByObjectIdResponse(id=803705, encodeId=db79803e054b, content=我家我妈吃的是香港万宁的中科胰糖安,每次三粒每天一次,午餐后打白天短效胰岛素,晚上睡前打甘精,准备借三伏酷暑之热吃肾力丹,预防高血压肾病和糖尿病肾病的发作, beContent=null, objectType=article, channel=null, level=null, likeNumber=87, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c2531680715, createdName=1de33e15m69(暂无匿称), createdTime=Tue Jul 21 16:26:49 CST 2020, time=2020-07-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1357544, encodeId=76ab135e544a5, content=<a href='/topic/show?id=b0702e84b9' target=_blank style='color:#2F92EE;'>#ART#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2784, encryptionId=b0702e84b9, topicName=ART)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=zhaojie88, createdTime=Fri Jun 26 14:45:11 CST 2020, time=2020-06-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1383633, encodeId=e355138363315, content=<a href='/topic/show?id=196a1101f7' target=_blank style='color:#2F92EE;'>#2型糖尿病患者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=1101, encryptionId=196a1101f7, topicName=2型糖尿病患者)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=ec19483, createdName=aids213, createdTime=Fri Jun 26 14:45:11 CST 2020, time=2020-06-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1474947, encodeId=dbfd14e4947c3, content=<a href='/topic/show?id=935fe6718e3' target=_blank style='color:#2F92EE;'>#糖尿病患者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=21, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=76718, encryptionId=935fe6718e3, topicName=糖尿病患者)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a38f7243741, createdName=xue8604, createdTime=Fri Jun 26 14:45:11 CST 2020, time=2020-06-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1559656, encodeId=e06d1559656a8, content=<a href='/topic/show?id=d86c4802198' target=_blank style='color:#2F92EE;'>#左室肥大#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=48021, encryptionId=d86c4802198, topicName=左室肥大)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=499d15008036, createdName=zgwhgch, createdTime=Fri Jun 26 14:45:11 CST 2020, time=2020-06-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1563325, encodeId=ef1d15633255f, content=<a href='/topic/show?id=f69d864413' target=_blank style='color:#2F92EE;'>#HEART#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=8644, encryptionId=f69d864413, topicName=HEART)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=80d715270048, createdName=slcumt, createdTime=Fri Jun 26 14:45:11 CST 2020, time=2020-06-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1565665, encodeId=4b8f15656654e, content=<a href='/topic/show?id=d86c4802198' target=_blank style='color:#2F92EE;'>#左室肥大#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=48021, encryptionId=d86c4802198, topicName=左室肥大)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=499d15008036, createdName=zgwhgch, createdTime=Fri Jun 26 14:45:11 CST 2020, time=2020-06-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=799710, encodeId=9b26e9971077, content=<a href='/topic/show?id=d90393941be' target=_blank style='color:#2F92EE;'>#达格列净#</a>列净类降糖药物将成为糖尿病治疗的核心药物。, beContent=null, objectType=article, channel=null, level=null, likeNumber=151, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=93941, encryptionId=d90393941be, topicName=达格列净)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220519/c2ab253484ee4527a2d4e9589a4821ac/45de9bf494a54becb2ea4369c9d11e85.jpg, createdBy=7a3710, createdName=lovetcm, createdTime=Thu Jun 25 07:59:03 CST 2020, time=2020-06-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1043190, encodeId=a69f104319050, content=谢谢MedSci提供最新的资讯, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=misszhang, createdTime=Thu Jun 25 02:45:11 CST 2020, time=2020-06-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=799683, encodeId=75b1e9968333, content=<a href='/topic/show?id=d20f1090c2' target=_blank style='color:#2F92EE;'>#2型糖尿病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=145, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=1090, encryptionId=d20f1090c2, topicName=2型糖尿病)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220519/c2ab253484ee4527a2d4e9589a4821ac/45de9bf494a54becb2ea4369c9d11e85.jpg, createdBy=7a3710, createdName=lovetcm, createdTime=Thu Jun 25 00:21:25 CST 2020, time=2020-06-25, status=1, ipAttribution=)]
    2020-06-26 zhaojie88
  3. [GetPortalCommentsPageByObjectIdResponse(id=803705, encodeId=db79803e054b, content=我家我妈吃的是香港万宁的中科胰糖安,每次三粒每天一次,午餐后打白天短效胰岛素,晚上睡前打甘精,准备借三伏酷暑之热吃肾力丹,预防高血压肾病和糖尿病肾病的发作, beContent=null, objectType=article, channel=null, level=null, likeNumber=87, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c2531680715, createdName=1de33e15m69(暂无匿称), createdTime=Tue Jul 21 16:26:49 CST 2020, time=2020-07-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1357544, encodeId=76ab135e544a5, content=<a href='/topic/show?id=b0702e84b9' target=_blank style='color:#2F92EE;'>#ART#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2784, encryptionId=b0702e84b9, topicName=ART)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=zhaojie88, createdTime=Fri Jun 26 14:45:11 CST 2020, time=2020-06-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1383633, encodeId=e355138363315, content=<a href='/topic/show?id=196a1101f7' target=_blank style='color:#2F92EE;'>#2型糖尿病患者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=1101, encryptionId=196a1101f7, topicName=2型糖尿病患者)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=ec19483, createdName=aids213, createdTime=Fri Jun 26 14:45:11 CST 2020, time=2020-06-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1474947, encodeId=dbfd14e4947c3, content=<a href='/topic/show?id=935fe6718e3' target=_blank style='color:#2F92EE;'>#糖尿病患者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=21, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=76718, encryptionId=935fe6718e3, topicName=糖尿病患者)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a38f7243741, createdName=xue8604, createdTime=Fri Jun 26 14:45:11 CST 2020, time=2020-06-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1559656, encodeId=e06d1559656a8, content=<a href='/topic/show?id=d86c4802198' target=_blank style='color:#2F92EE;'>#左室肥大#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=48021, encryptionId=d86c4802198, topicName=左室肥大)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=499d15008036, createdName=zgwhgch, createdTime=Fri Jun 26 14:45:11 CST 2020, time=2020-06-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1563325, encodeId=ef1d15633255f, content=<a href='/topic/show?id=f69d864413' target=_blank style='color:#2F92EE;'>#HEART#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=8644, encryptionId=f69d864413, topicName=HEART)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=80d715270048, createdName=slcumt, createdTime=Fri Jun 26 14:45:11 CST 2020, time=2020-06-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1565665, encodeId=4b8f15656654e, content=<a href='/topic/show?id=d86c4802198' target=_blank style='color:#2F92EE;'>#左室肥大#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=48021, encryptionId=d86c4802198, topicName=左室肥大)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=499d15008036, createdName=zgwhgch, createdTime=Fri Jun 26 14:45:11 CST 2020, time=2020-06-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=799710, encodeId=9b26e9971077, content=<a href='/topic/show?id=d90393941be' target=_blank style='color:#2F92EE;'>#达格列净#</a>列净类降糖药物将成为糖尿病治疗的核心药物。, beContent=null, objectType=article, channel=null, level=null, likeNumber=151, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=93941, encryptionId=d90393941be, topicName=达格列净)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220519/c2ab253484ee4527a2d4e9589a4821ac/45de9bf494a54becb2ea4369c9d11e85.jpg, createdBy=7a3710, createdName=lovetcm, createdTime=Thu Jun 25 07:59:03 CST 2020, time=2020-06-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1043190, encodeId=a69f104319050, content=谢谢MedSci提供最新的资讯, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=misszhang, createdTime=Thu Jun 25 02:45:11 CST 2020, time=2020-06-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=799683, encodeId=75b1e9968333, content=<a href='/topic/show?id=d20f1090c2' target=_blank style='color:#2F92EE;'>#2型糖尿病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=145, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=1090, encryptionId=d20f1090c2, topicName=2型糖尿病)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220519/c2ab253484ee4527a2d4e9589a4821ac/45de9bf494a54becb2ea4369c9d11e85.jpg, createdBy=7a3710, createdName=lovetcm, createdTime=Thu Jun 25 00:21:25 CST 2020, time=2020-06-25, status=1, ipAttribution=)]
  4. [GetPortalCommentsPageByObjectIdResponse(id=803705, encodeId=db79803e054b, content=我家我妈吃的是香港万宁的中科胰糖安,每次三粒每天一次,午餐后打白天短效胰岛素,晚上睡前打甘精,准备借三伏酷暑之热吃肾力丹,预防高血压肾病和糖尿病肾病的发作, beContent=null, objectType=article, channel=null, level=null, likeNumber=87, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c2531680715, createdName=1de33e15m69(暂无匿称), createdTime=Tue Jul 21 16:26:49 CST 2020, time=2020-07-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1357544, encodeId=76ab135e544a5, content=<a href='/topic/show?id=b0702e84b9' target=_blank style='color:#2F92EE;'>#ART#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2784, encryptionId=b0702e84b9, topicName=ART)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=zhaojie88, createdTime=Fri Jun 26 14:45:11 CST 2020, time=2020-06-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1383633, encodeId=e355138363315, content=<a href='/topic/show?id=196a1101f7' target=_blank style='color:#2F92EE;'>#2型糖尿病患者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=1101, encryptionId=196a1101f7, topicName=2型糖尿病患者)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=ec19483, createdName=aids213, createdTime=Fri Jun 26 14:45:11 CST 2020, time=2020-06-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1474947, encodeId=dbfd14e4947c3, content=<a href='/topic/show?id=935fe6718e3' target=_blank style='color:#2F92EE;'>#糖尿病患者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=21, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=76718, encryptionId=935fe6718e3, topicName=糖尿病患者)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a38f7243741, createdName=xue8604, createdTime=Fri Jun 26 14:45:11 CST 2020, time=2020-06-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1559656, encodeId=e06d1559656a8, content=<a href='/topic/show?id=d86c4802198' target=_blank style='color:#2F92EE;'>#左室肥大#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=48021, encryptionId=d86c4802198, topicName=左室肥大)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=499d15008036, createdName=zgwhgch, createdTime=Fri Jun 26 14:45:11 CST 2020, time=2020-06-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1563325, encodeId=ef1d15633255f, content=<a href='/topic/show?id=f69d864413' target=_blank style='color:#2F92EE;'>#HEART#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=8644, encryptionId=f69d864413, topicName=HEART)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=80d715270048, createdName=slcumt, createdTime=Fri Jun 26 14:45:11 CST 2020, time=2020-06-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1565665, encodeId=4b8f15656654e, content=<a href='/topic/show?id=d86c4802198' target=_blank style='color:#2F92EE;'>#左室肥大#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=48021, encryptionId=d86c4802198, topicName=左室肥大)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=499d15008036, createdName=zgwhgch, createdTime=Fri Jun 26 14:45:11 CST 2020, time=2020-06-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=799710, encodeId=9b26e9971077, content=<a href='/topic/show?id=d90393941be' target=_blank style='color:#2F92EE;'>#达格列净#</a>列净类降糖药物将成为糖尿病治疗的核心药物。, beContent=null, objectType=article, channel=null, level=null, likeNumber=151, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=93941, encryptionId=d90393941be, topicName=达格列净)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220519/c2ab253484ee4527a2d4e9589a4821ac/45de9bf494a54becb2ea4369c9d11e85.jpg, createdBy=7a3710, createdName=lovetcm, createdTime=Thu Jun 25 07:59:03 CST 2020, time=2020-06-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1043190, encodeId=a69f104319050, content=谢谢MedSci提供最新的资讯, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=misszhang, createdTime=Thu Jun 25 02:45:11 CST 2020, time=2020-06-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=799683, encodeId=75b1e9968333, content=<a href='/topic/show?id=d20f1090c2' target=_blank style='color:#2F92EE;'>#2型糖尿病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=145, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=1090, encryptionId=d20f1090c2, topicName=2型糖尿病)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220519/c2ab253484ee4527a2d4e9589a4821ac/45de9bf494a54becb2ea4369c9d11e85.jpg, createdBy=7a3710, createdName=lovetcm, createdTime=Thu Jun 25 00:21:25 CST 2020, time=2020-06-25, status=1, ipAttribution=)]
  5. [GetPortalCommentsPageByObjectIdResponse(id=803705, encodeId=db79803e054b, content=我家我妈吃的是香港万宁的中科胰糖安,每次三粒每天一次,午餐后打白天短效胰岛素,晚上睡前打甘精,准备借三伏酷暑之热吃肾力丹,预防高血压肾病和糖尿病肾病的发作, beContent=null, objectType=article, channel=null, level=null, likeNumber=87, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c2531680715, createdName=1de33e15m69(暂无匿称), createdTime=Tue Jul 21 16:26:49 CST 2020, time=2020-07-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1357544, encodeId=76ab135e544a5, content=<a href='/topic/show?id=b0702e84b9' target=_blank style='color:#2F92EE;'>#ART#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2784, encryptionId=b0702e84b9, topicName=ART)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=zhaojie88, createdTime=Fri Jun 26 14:45:11 CST 2020, time=2020-06-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1383633, encodeId=e355138363315, content=<a href='/topic/show?id=196a1101f7' target=_blank style='color:#2F92EE;'>#2型糖尿病患者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=1101, encryptionId=196a1101f7, topicName=2型糖尿病患者)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=ec19483, createdName=aids213, createdTime=Fri Jun 26 14:45:11 CST 2020, time=2020-06-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1474947, encodeId=dbfd14e4947c3, content=<a href='/topic/show?id=935fe6718e3' target=_blank style='color:#2F92EE;'>#糖尿病患者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=21, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=76718, encryptionId=935fe6718e3, topicName=糖尿病患者)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a38f7243741, createdName=xue8604, createdTime=Fri Jun 26 14:45:11 CST 2020, time=2020-06-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1559656, encodeId=e06d1559656a8, content=<a href='/topic/show?id=d86c4802198' target=_blank style='color:#2F92EE;'>#左室肥大#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=48021, encryptionId=d86c4802198, topicName=左室肥大)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=499d15008036, createdName=zgwhgch, createdTime=Fri Jun 26 14:45:11 CST 2020, time=2020-06-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1563325, encodeId=ef1d15633255f, content=<a href='/topic/show?id=f69d864413' target=_blank style='color:#2F92EE;'>#HEART#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=8644, encryptionId=f69d864413, topicName=HEART)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=80d715270048, createdName=slcumt, createdTime=Fri Jun 26 14:45:11 CST 2020, time=2020-06-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1565665, encodeId=4b8f15656654e, content=<a href='/topic/show?id=d86c4802198' target=_blank style='color:#2F92EE;'>#左室肥大#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=48021, encryptionId=d86c4802198, topicName=左室肥大)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=499d15008036, createdName=zgwhgch, createdTime=Fri Jun 26 14:45:11 CST 2020, time=2020-06-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=799710, encodeId=9b26e9971077, content=<a href='/topic/show?id=d90393941be' target=_blank style='color:#2F92EE;'>#达格列净#</a>列净类降糖药物将成为糖尿病治疗的核心药物。, beContent=null, objectType=article, channel=null, level=null, likeNumber=151, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=93941, encryptionId=d90393941be, topicName=达格列净)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220519/c2ab253484ee4527a2d4e9589a4821ac/45de9bf494a54becb2ea4369c9d11e85.jpg, createdBy=7a3710, createdName=lovetcm, createdTime=Thu Jun 25 07:59:03 CST 2020, time=2020-06-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1043190, encodeId=a69f104319050, content=谢谢MedSci提供最新的资讯, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=misszhang, createdTime=Thu Jun 25 02:45:11 CST 2020, time=2020-06-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=799683, encodeId=75b1e9968333, content=<a href='/topic/show?id=d20f1090c2' target=_blank style='color:#2F92EE;'>#2型糖尿病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=145, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=1090, encryptionId=d20f1090c2, topicName=2型糖尿病)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220519/c2ab253484ee4527a2d4e9589a4821ac/45de9bf494a54becb2ea4369c9d11e85.jpg, createdBy=7a3710, createdName=lovetcm, createdTime=Thu Jun 25 00:21:25 CST 2020, time=2020-06-25, status=1, ipAttribution=)]
  6. [GetPortalCommentsPageByObjectIdResponse(id=803705, encodeId=db79803e054b, content=我家我妈吃的是香港万宁的中科胰糖安,每次三粒每天一次,午餐后打白天短效胰岛素,晚上睡前打甘精,准备借三伏酷暑之热吃肾力丹,预防高血压肾病和糖尿病肾病的发作, beContent=null, objectType=article, channel=null, level=null, likeNumber=87, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c2531680715, createdName=1de33e15m69(暂无匿称), createdTime=Tue Jul 21 16:26:49 CST 2020, time=2020-07-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1357544, encodeId=76ab135e544a5, content=<a href='/topic/show?id=b0702e84b9' target=_blank style='color:#2F92EE;'>#ART#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2784, encryptionId=b0702e84b9, topicName=ART)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=zhaojie88, createdTime=Fri Jun 26 14:45:11 CST 2020, time=2020-06-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1383633, encodeId=e355138363315, content=<a href='/topic/show?id=196a1101f7' target=_blank style='color:#2F92EE;'>#2型糖尿病患者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=1101, encryptionId=196a1101f7, topicName=2型糖尿病患者)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=ec19483, createdName=aids213, createdTime=Fri Jun 26 14:45:11 CST 2020, time=2020-06-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1474947, encodeId=dbfd14e4947c3, content=<a href='/topic/show?id=935fe6718e3' target=_blank style='color:#2F92EE;'>#糖尿病患者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=21, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=76718, encryptionId=935fe6718e3, topicName=糖尿病患者)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a38f7243741, createdName=xue8604, createdTime=Fri Jun 26 14:45:11 CST 2020, time=2020-06-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1559656, encodeId=e06d1559656a8, content=<a href='/topic/show?id=d86c4802198' target=_blank style='color:#2F92EE;'>#左室肥大#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=48021, encryptionId=d86c4802198, topicName=左室肥大)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=499d15008036, createdName=zgwhgch, createdTime=Fri Jun 26 14:45:11 CST 2020, time=2020-06-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1563325, encodeId=ef1d15633255f, content=<a href='/topic/show?id=f69d864413' target=_blank style='color:#2F92EE;'>#HEART#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=8644, encryptionId=f69d864413, topicName=HEART)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=80d715270048, createdName=slcumt, createdTime=Fri Jun 26 14:45:11 CST 2020, time=2020-06-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1565665, encodeId=4b8f15656654e, content=<a href='/topic/show?id=d86c4802198' target=_blank style='color:#2F92EE;'>#左室肥大#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=48021, encryptionId=d86c4802198, topicName=左室肥大)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=499d15008036, createdName=zgwhgch, createdTime=Fri Jun 26 14:45:11 CST 2020, time=2020-06-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=799710, encodeId=9b26e9971077, content=<a href='/topic/show?id=d90393941be' target=_blank style='color:#2F92EE;'>#达格列净#</a>列净类降糖药物将成为糖尿病治疗的核心药物。, beContent=null, objectType=article, channel=null, level=null, likeNumber=151, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=93941, encryptionId=d90393941be, topicName=达格列净)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220519/c2ab253484ee4527a2d4e9589a4821ac/45de9bf494a54becb2ea4369c9d11e85.jpg, createdBy=7a3710, createdName=lovetcm, createdTime=Thu Jun 25 07:59:03 CST 2020, time=2020-06-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1043190, encodeId=a69f104319050, content=谢谢MedSci提供最新的资讯, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=misszhang, createdTime=Thu Jun 25 02:45:11 CST 2020, time=2020-06-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=799683, encodeId=75b1e9968333, content=<a href='/topic/show?id=d20f1090c2' target=_blank style='color:#2F92EE;'>#2型糖尿病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=145, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=1090, encryptionId=d20f1090c2, topicName=2型糖尿病)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220519/c2ab253484ee4527a2d4e9589a4821ac/45de9bf494a54becb2ea4369c9d11e85.jpg, createdBy=7a3710, createdName=lovetcm, createdTime=Thu Jun 25 00:21:25 CST 2020, time=2020-06-25, status=1, ipAttribution=)]
    2020-06-26 slcumt
  7. [GetPortalCommentsPageByObjectIdResponse(id=803705, encodeId=db79803e054b, content=我家我妈吃的是香港万宁的中科胰糖安,每次三粒每天一次,午餐后打白天短效胰岛素,晚上睡前打甘精,准备借三伏酷暑之热吃肾力丹,预防高血压肾病和糖尿病肾病的发作, beContent=null, objectType=article, channel=null, level=null, likeNumber=87, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c2531680715, createdName=1de33e15m69(暂无匿称), createdTime=Tue Jul 21 16:26:49 CST 2020, time=2020-07-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1357544, encodeId=76ab135e544a5, content=<a href='/topic/show?id=b0702e84b9' target=_blank style='color:#2F92EE;'>#ART#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2784, encryptionId=b0702e84b9, topicName=ART)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=zhaojie88, createdTime=Fri Jun 26 14:45:11 CST 2020, time=2020-06-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1383633, encodeId=e355138363315, content=<a href='/topic/show?id=196a1101f7' target=_blank style='color:#2F92EE;'>#2型糖尿病患者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=1101, encryptionId=196a1101f7, topicName=2型糖尿病患者)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=ec19483, createdName=aids213, createdTime=Fri Jun 26 14:45:11 CST 2020, time=2020-06-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1474947, encodeId=dbfd14e4947c3, content=<a href='/topic/show?id=935fe6718e3' target=_blank style='color:#2F92EE;'>#糖尿病患者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=21, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=76718, encryptionId=935fe6718e3, topicName=糖尿病患者)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a38f7243741, createdName=xue8604, createdTime=Fri Jun 26 14:45:11 CST 2020, time=2020-06-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1559656, encodeId=e06d1559656a8, content=<a href='/topic/show?id=d86c4802198' target=_blank style='color:#2F92EE;'>#左室肥大#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=48021, encryptionId=d86c4802198, topicName=左室肥大)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=499d15008036, createdName=zgwhgch, createdTime=Fri Jun 26 14:45:11 CST 2020, time=2020-06-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1563325, encodeId=ef1d15633255f, content=<a href='/topic/show?id=f69d864413' target=_blank style='color:#2F92EE;'>#HEART#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=8644, encryptionId=f69d864413, topicName=HEART)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=80d715270048, createdName=slcumt, createdTime=Fri Jun 26 14:45:11 CST 2020, time=2020-06-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1565665, encodeId=4b8f15656654e, content=<a href='/topic/show?id=d86c4802198' target=_blank style='color:#2F92EE;'>#左室肥大#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=48021, encryptionId=d86c4802198, topicName=左室肥大)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=499d15008036, createdName=zgwhgch, createdTime=Fri Jun 26 14:45:11 CST 2020, time=2020-06-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=799710, encodeId=9b26e9971077, content=<a href='/topic/show?id=d90393941be' target=_blank style='color:#2F92EE;'>#达格列净#</a>列净类降糖药物将成为糖尿病治疗的核心药物。, beContent=null, objectType=article, channel=null, level=null, likeNumber=151, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=93941, encryptionId=d90393941be, topicName=达格列净)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220519/c2ab253484ee4527a2d4e9589a4821ac/45de9bf494a54becb2ea4369c9d11e85.jpg, createdBy=7a3710, createdName=lovetcm, createdTime=Thu Jun 25 07:59:03 CST 2020, time=2020-06-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1043190, encodeId=a69f104319050, content=谢谢MedSci提供最新的资讯, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=misszhang, createdTime=Thu Jun 25 02:45:11 CST 2020, time=2020-06-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=799683, encodeId=75b1e9968333, content=<a href='/topic/show?id=d20f1090c2' target=_blank style='color:#2F92EE;'>#2型糖尿病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=145, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=1090, encryptionId=d20f1090c2, topicName=2型糖尿病)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220519/c2ab253484ee4527a2d4e9589a4821ac/45de9bf494a54becb2ea4369c9d11e85.jpg, createdBy=7a3710, createdName=lovetcm, createdTime=Thu Jun 25 00:21:25 CST 2020, time=2020-06-25, status=1, ipAttribution=)]
  8. [GetPortalCommentsPageByObjectIdResponse(id=803705, encodeId=db79803e054b, content=我家我妈吃的是香港万宁的中科胰糖安,每次三粒每天一次,午餐后打白天短效胰岛素,晚上睡前打甘精,准备借三伏酷暑之热吃肾力丹,预防高血压肾病和糖尿病肾病的发作, beContent=null, objectType=article, channel=null, level=null, likeNumber=87, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c2531680715, createdName=1de33e15m69(暂无匿称), createdTime=Tue Jul 21 16:26:49 CST 2020, time=2020-07-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1357544, encodeId=76ab135e544a5, content=<a href='/topic/show?id=b0702e84b9' target=_blank style='color:#2F92EE;'>#ART#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2784, encryptionId=b0702e84b9, topicName=ART)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=zhaojie88, createdTime=Fri Jun 26 14:45:11 CST 2020, time=2020-06-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1383633, encodeId=e355138363315, content=<a href='/topic/show?id=196a1101f7' target=_blank style='color:#2F92EE;'>#2型糖尿病患者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=1101, encryptionId=196a1101f7, topicName=2型糖尿病患者)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=ec19483, createdName=aids213, createdTime=Fri Jun 26 14:45:11 CST 2020, time=2020-06-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1474947, encodeId=dbfd14e4947c3, content=<a href='/topic/show?id=935fe6718e3' target=_blank style='color:#2F92EE;'>#糖尿病患者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=21, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=76718, encryptionId=935fe6718e3, topicName=糖尿病患者)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a38f7243741, createdName=xue8604, createdTime=Fri Jun 26 14:45:11 CST 2020, time=2020-06-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1559656, encodeId=e06d1559656a8, content=<a href='/topic/show?id=d86c4802198' target=_blank style='color:#2F92EE;'>#左室肥大#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=48021, encryptionId=d86c4802198, topicName=左室肥大)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=499d15008036, createdName=zgwhgch, createdTime=Fri Jun 26 14:45:11 CST 2020, time=2020-06-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1563325, encodeId=ef1d15633255f, content=<a href='/topic/show?id=f69d864413' target=_blank style='color:#2F92EE;'>#HEART#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=8644, encryptionId=f69d864413, topicName=HEART)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=80d715270048, createdName=slcumt, createdTime=Fri Jun 26 14:45:11 CST 2020, time=2020-06-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1565665, encodeId=4b8f15656654e, content=<a href='/topic/show?id=d86c4802198' target=_blank style='color:#2F92EE;'>#左室肥大#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=48021, encryptionId=d86c4802198, topicName=左室肥大)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=499d15008036, createdName=zgwhgch, createdTime=Fri Jun 26 14:45:11 CST 2020, time=2020-06-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=799710, encodeId=9b26e9971077, content=<a href='/topic/show?id=d90393941be' target=_blank style='color:#2F92EE;'>#达格列净#</a>列净类降糖药物将成为糖尿病治疗的核心药物。, beContent=null, objectType=article, channel=null, level=null, likeNumber=151, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=93941, encryptionId=d90393941be, topicName=达格列净)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220519/c2ab253484ee4527a2d4e9589a4821ac/45de9bf494a54becb2ea4369c9d11e85.jpg, createdBy=7a3710, createdName=lovetcm, createdTime=Thu Jun 25 07:59:03 CST 2020, time=2020-06-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1043190, encodeId=a69f104319050, content=谢谢MedSci提供最新的资讯, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=misszhang, createdTime=Thu Jun 25 02:45:11 CST 2020, time=2020-06-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=799683, encodeId=75b1e9968333, content=<a href='/topic/show?id=d20f1090c2' target=_blank style='color:#2F92EE;'>#2型糖尿病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=145, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=1090, encryptionId=d20f1090c2, topicName=2型糖尿病)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220519/c2ab253484ee4527a2d4e9589a4821ac/45de9bf494a54becb2ea4369c9d11e85.jpg, createdBy=7a3710, createdName=lovetcm, createdTime=Thu Jun 25 00:21:25 CST 2020, time=2020-06-25, status=1, ipAttribution=)]
    2020-06-25 lovetcm

    #达格列净#列净类降糖药物将成为糖尿病治疗的核心药物。

    0

  9. [GetPortalCommentsPageByObjectIdResponse(id=803705, encodeId=db79803e054b, content=我家我妈吃的是香港万宁的中科胰糖安,每次三粒每天一次,午餐后打白天短效胰岛素,晚上睡前打甘精,准备借三伏酷暑之热吃肾力丹,预防高血压肾病和糖尿病肾病的发作, beContent=null, objectType=article, channel=null, level=null, likeNumber=87, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c2531680715, createdName=1de33e15m69(暂无匿称), createdTime=Tue Jul 21 16:26:49 CST 2020, time=2020-07-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1357544, encodeId=76ab135e544a5, content=<a href='/topic/show?id=b0702e84b9' target=_blank style='color:#2F92EE;'>#ART#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2784, encryptionId=b0702e84b9, topicName=ART)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=zhaojie88, createdTime=Fri Jun 26 14:45:11 CST 2020, time=2020-06-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1383633, encodeId=e355138363315, content=<a href='/topic/show?id=196a1101f7' target=_blank style='color:#2F92EE;'>#2型糖尿病患者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=1101, encryptionId=196a1101f7, topicName=2型糖尿病患者)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=ec19483, createdName=aids213, createdTime=Fri Jun 26 14:45:11 CST 2020, time=2020-06-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1474947, encodeId=dbfd14e4947c3, content=<a href='/topic/show?id=935fe6718e3' target=_blank style='color:#2F92EE;'>#糖尿病患者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=21, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=76718, encryptionId=935fe6718e3, topicName=糖尿病患者)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a38f7243741, createdName=xue8604, createdTime=Fri Jun 26 14:45:11 CST 2020, time=2020-06-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1559656, encodeId=e06d1559656a8, content=<a href='/topic/show?id=d86c4802198' target=_blank style='color:#2F92EE;'>#左室肥大#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=48021, encryptionId=d86c4802198, topicName=左室肥大)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=499d15008036, createdName=zgwhgch, createdTime=Fri Jun 26 14:45:11 CST 2020, time=2020-06-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1563325, encodeId=ef1d15633255f, content=<a href='/topic/show?id=f69d864413' target=_blank style='color:#2F92EE;'>#HEART#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=8644, encryptionId=f69d864413, topicName=HEART)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=80d715270048, createdName=slcumt, createdTime=Fri Jun 26 14:45:11 CST 2020, time=2020-06-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1565665, encodeId=4b8f15656654e, content=<a href='/topic/show?id=d86c4802198' target=_blank style='color:#2F92EE;'>#左室肥大#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=48021, encryptionId=d86c4802198, topicName=左室肥大)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=499d15008036, createdName=zgwhgch, createdTime=Fri Jun 26 14:45:11 CST 2020, time=2020-06-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=799710, encodeId=9b26e9971077, content=<a href='/topic/show?id=d90393941be' target=_blank style='color:#2F92EE;'>#达格列净#</a>列净类降糖药物将成为糖尿病治疗的核心药物。, beContent=null, objectType=article, channel=null, level=null, likeNumber=151, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=93941, encryptionId=d90393941be, topicName=达格列净)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220519/c2ab253484ee4527a2d4e9589a4821ac/45de9bf494a54becb2ea4369c9d11e85.jpg, createdBy=7a3710, createdName=lovetcm, createdTime=Thu Jun 25 07:59:03 CST 2020, time=2020-06-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1043190, encodeId=a69f104319050, content=谢谢MedSci提供最新的资讯, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=misszhang, createdTime=Thu Jun 25 02:45:11 CST 2020, time=2020-06-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=799683, encodeId=75b1e9968333, content=<a href='/topic/show?id=d20f1090c2' target=_blank style='color:#2F92EE;'>#2型糖尿病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=145, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=1090, encryptionId=d20f1090c2, topicName=2型糖尿病)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220519/c2ab253484ee4527a2d4e9589a4821ac/45de9bf494a54becb2ea4369c9d11e85.jpg, createdBy=7a3710, createdName=lovetcm, createdTime=Thu Jun 25 00:21:25 CST 2020, time=2020-06-25, status=1, ipAttribution=)]
    2020-06-25 misszhang

    谢谢MedSci提供最新的资讯

    0

  10. [GetPortalCommentsPageByObjectIdResponse(id=803705, encodeId=db79803e054b, content=我家我妈吃的是香港万宁的中科胰糖安,每次三粒每天一次,午餐后打白天短效胰岛素,晚上睡前打甘精,准备借三伏酷暑之热吃肾力丹,预防高血压肾病和糖尿病肾病的发作, beContent=null, objectType=article, channel=null, level=null, likeNumber=87, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c2531680715, createdName=1de33e15m69(暂无匿称), createdTime=Tue Jul 21 16:26:49 CST 2020, time=2020-07-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1357544, encodeId=76ab135e544a5, content=<a href='/topic/show?id=b0702e84b9' target=_blank style='color:#2F92EE;'>#ART#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2784, encryptionId=b0702e84b9, topicName=ART)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=zhaojie88, createdTime=Fri Jun 26 14:45:11 CST 2020, time=2020-06-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1383633, encodeId=e355138363315, content=<a href='/topic/show?id=196a1101f7' target=_blank style='color:#2F92EE;'>#2型糖尿病患者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=1101, encryptionId=196a1101f7, topicName=2型糖尿病患者)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=ec19483, createdName=aids213, createdTime=Fri Jun 26 14:45:11 CST 2020, time=2020-06-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1474947, encodeId=dbfd14e4947c3, content=<a href='/topic/show?id=935fe6718e3' target=_blank style='color:#2F92EE;'>#糖尿病患者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=21, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=76718, encryptionId=935fe6718e3, topicName=糖尿病患者)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a38f7243741, createdName=xue8604, createdTime=Fri Jun 26 14:45:11 CST 2020, time=2020-06-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1559656, encodeId=e06d1559656a8, content=<a href='/topic/show?id=d86c4802198' target=_blank style='color:#2F92EE;'>#左室肥大#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=48021, encryptionId=d86c4802198, topicName=左室肥大)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=499d15008036, createdName=zgwhgch, createdTime=Fri Jun 26 14:45:11 CST 2020, time=2020-06-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1563325, encodeId=ef1d15633255f, content=<a href='/topic/show?id=f69d864413' target=_blank style='color:#2F92EE;'>#HEART#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=8644, encryptionId=f69d864413, topicName=HEART)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=80d715270048, createdName=slcumt, createdTime=Fri Jun 26 14:45:11 CST 2020, time=2020-06-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1565665, encodeId=4b8f15656654e, content=<a href='/topic/show?id=d86c4802198' target=_blank style='color:#2F92EE;'>#左室肥大#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=48021, encryptionId=d86c4802198, topicName=左室肥大)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=499d15008036, createdName=zgwhgch, createdTime=Fri Jun 26 14:45:11 CST 2020, time=2020-06-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=799710, encodeId=9b26e9971077, content=<a href='/topic/show?id=d90393941be' target=_blank style='color:#2F92EE;'>#达格列净#</a>列净类降糖药物将成为糖尿病治疗的核心药物。, beContent=null, objectType=article, channel=null, level=null, likeNumber=151, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=93941, encryptionId=d90393941be, topicName=达格列净)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220519/c2ab253484ee4527a2d4e9589a4821ac/45de9bf494a54becb2ea4369c9d11e85.jpg, createdBy=7a3710, createdName=lovetcm, createdTime=Thu Jun 25 07:59:03 CST 2020, time=2020-06-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1043190, encodeId=a69f104319050, content=谢谢MedSci提供最新的资讯, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=misszhang, createdTime=Thu Jun 25 02:45:11 CST 2020, time=2020-06-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=799683, encodeId=75b1e9968333, content=<a href='/topic/show?id=d20f1090c2' target=_blank style='color:#2F92EE;'>#2型糖尿病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=145, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=1090, encryptionId=d20f1090c2, topicName=2型糖尿病)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220519/c2ab253484ee4527a2d4e9589a4821ac/45de9bf494a54becb2ea4369c9d11e85.jpg, createdBy=7a3710, createdName=lovetcm, createdTime=Thu Jun 25 00:21:25 CST 2020, time=2020-06-25, status=1, ipAttribution=)]

相关资讯

Diabetes Obes Metab:缬沙坦,贝那普利及其组合对2型糖尿病明显肾病的作用

本研究旨在评估血管紧张素转换酶(ACE)抑制剂和血管紧张素Ⅱ受体阻滞剂(ARB)联合治疗是否比ACE抑制剂或ARB单药治疗对2型糖尿病和显性肾病患者的肾脏保护作用更大。

Clin J Am Soc Nephrol:Imarikiren在2型糖尿病和微量白蛋白尿患者中的疗效和安全性

伊马利克仑是一种新型的、强效的、选择性的直接肾素抑制剂,在临床开发过程中表现出较高的口服可用性,用于治疗糖尿病肾病。我们评估了伊马利克仑在2型糖尿病和微量白蛋白尿患者中的疗效和安全性。

JCEM:2型糖尿病相关的多发性神经病患者疼痛与血管事件和死亡率相关

该研究发现DPN患者疼痛与血管事件和死亡风险增加之间存在显著关联,这些结果表明值得对DPN患者的危险因素和自然疼痛史进行纵向研究。

Metabolism:DPP-4抑制剂在2型糖尿病治疗中的疗效和安全性

心血管结局试验已证明采用西他列汀、沙格列汀、阿格列汀、利那列汀和维达列汀治疗的患者对于缺血性事件具有心血管安全性。研究显示沙格列汀治疗的患者住院率增加的数据似乎不是药物类别的效应。

J Am Soc Nephrol:白蛋白尿而非GFR的变化与2型糖尿病患者肾脏结构的早期变化有关

在1型糖尿病中,GFR和尿液白蛋白与肌酐比值(ACR)的变化与反映疾病进展的肾脏结构变化有关。然而,这种变化尚未在2型糖尿病中进行研究。

III期临床试验证明:Dorzagliatin单药治疗2型糖尿病疗效确切

专注于研发糖尿病疗法的华领医药(Hua Medicine)今日公布了III期SEED研究的第一阶段和第三阶段的主要成果。