J Periodontol:自体富血小板纤维蛋白膜在龈沟液中生长因子水平与牙周愈合中的优势

2017-08-16 MedSci MedSci原创

本研究评估血小板富集纤维蛋白(PRF)与常规瓣膜手术联合对龈沟液(GCF)和牙周愈合中生长因子水平的影响。

本研究评估血小板富集纤维蛋白(PRF)与常规瓣膜手术联合对龈沟液(GCF)和牙周愈合中生长因子水平的影响。

26例慢性牙周炎患者(52个位点)均采用自体PRF,开放瓣清创术(OFD + PRF)或单独使用OFD治疗。手术前和手术后2,4,6周对GCF生长因子水平进行分析,临床参数如探诊深度(PD),相对临床附着水平(rCAL)和牙龈边缘水平(GML)在术前和术后9个月测量。

结果:OFD + PRF位点的平均PD减少和rCAL增加明显高于OFD位点。平均GML变化在OFD位点为-0.38±0.10mm,试验组为0.11±0.08mm;两组间差异有统计学意义(P <0.05)。与术前数据相比,两组均显示2周时成纤维细胞生长因子-2,转化生长因子-β1和血小板衍生生长因子-BB的表达水平升高,随后在4周和6周时减少。在2周和4周时,与OFD组相比,OFD + PRF组的生长因子水平显着升高。

结论:PRF膜与OFD联合时,在2-4周,血管发生生物标志物GCF浓度更高,并且对常规皮瓣部位而言牙周愈合愈佳。

原始出处:

Taner Arabaci, Oguz Kose, Mevlut Albayrak, et al. Advantages of Autologous Platelet-Rich Fibrin Membrane on Gingival Crevicular Fluid Growth Factor Levels and Periodontal Healing: A Randomized Split-Mouth Clinical Study. Journal of periodontal research. 2017 August. doi: 10.1902/ jop.2017.160485

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    2017-08-16 惠映实验室

    学习了,谢谢。

    0

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牙周病(PD)是糖尿病患者的第六位好发的并发症。研究人员已用糖尿病啮齿类动物模型证明糖尿病会增加龋齿,而溃疡性炎症可能会对邻近周围组织有强烈影响。但是,尚不能完全排除高血糖可诱发糖尿病动物患PD的可能性。本研究的目的是通过预防溃疡性炎症及氟化物的管理,来验证PD是否在糖尿病动物模型中存在。注射四氧嘧啶的F344大鼠(1型糖尿病模型)和db/db小鼠(2型糖尿病模型),分别给予自来水或含氟的自来水。

重度牙周炎诊断标准及特殊人群牙周病治疗原则的中国专家共识

近年来,广大临床医师对牙周病诊疗的重视程度日益增加,但在临床对牙周病的诊治工作中常面临一些困惑,缺乏获得具体指导的途径,这突显了对牙周病临床诊疗的循证需求。为此,中华口腔医学会牙周病学专业委员会组织专家,根据国内外现有循证医学证据和专家经验,在充分讨论的基础上制定了本共识,以期指导和帮助中国广大临床医师在牙周病的临床诊疗中做出更合理的诊疗决策。

J Periodontol:抗蛋白酶预警器Trappin-2与牙周炎患者促炎症因子的负相关性研究

Trappin-2是一种有效的具有生物活性的丝氨酸蛋白酶抑制剂,它具有抗炎特性并且被认为是一个“抗蛋白酶预警器”。尽管Trappin-2在数种慢性感染中的重要性已经得到验证,但是它在牙周炎中潜在的调控作用还不清楚。这篇研究的目的是为了检测牙周健康的个体和牙龈炎或广泛性慢性牙周炎(CP)又或者侵袭性牙周炎(G-AgP)患者唾液中Trappin-2 和白细胞介素1β(IL-1β)的表达水平。

J Periodontol:系统牙周治疗对于高血压前期牙周炎患者血压及内皮微粒的影响:一项随机对照试验

目前,虽然一些研究显示牙周炎与血压(BP)升高之间存在正相关关系。但对于未进行任何抗高血压治疗牙周炎患者,系统牙周治疗对BP水平下降和内皮微粒(EMP)的影响的研究仍缺乏。因此,本临床试验探讨了系统牙周治疗是否会降低高血压前期牙周炎的患者的血压水平和EMP。

J Periodontol:同一的个体种植体与天然牙周围的生物标志物和细菌

该横断面研究评估了种植体周围龈沟液(PICF)/牙龈沟液(GCF)中的细胞因子水平以及来自同一人群临床健康或患病位点的龈下/粘膜下菌斑的选择。