Nat Commun:你不经意的饮食习惯可能正在“喂养”癌细胞

2017-05-27 Heather_z727 来宝网

在一项新的研究中,来自德克萨斯大学的科学家们发现,某些类型的癌症患者比其他人更喜欢吃甜食。长久以来,科学界一直怀疑某些癌细胞需要依靠糖分作为它们的能量来源,此次事实证明,一个特定细胞癌—鳞状细胞癌对糖分最依赖。完整的研究报告发表与5月26日《自然通讯》在线期刊上。



【研究加强糖和癌症的关系】在一项新的研究中,来自德克萨斯大学的科学家们发现,某些类型的癌症患者比其他人更喜欢吃甜食。长久以来,科学界一直怀疑某些癌细胞需要依靠糖分作为它们的能量来源,此次事实证明,一个特定细胞癌—鳞状细胞癌对糖分最依赖。完整的研究报告发表与5月26日《自然通讯》在线期刊上。

来自德克萨斯大学的研究人员们首先着手调查非小细胞肺癌两种主要亚型的新陈代谢,恶性腺癌(ADC)和鳞状细胞癌(SqCC)。大约四分之一的肺癌患者都是SqCC,但是治疗却非常困难,而且效果一般。

研究人员表示:“在此前的研究中,我们认为这两种类型癌症的新陈代谢是相似的,但是,在此次试验中,我们的证据证明了它们完全不同。这些发现证明癌症并不是一种单一的疾病,而是多种疾病的共同体。”

“我们通过不同的角度进行了试验,结果显示在鳞状细胞癌中,葡萄糖转运蛋白高活跃,肺腺癌则不然。我们的实验首次证明了不同癌症类型新陈代谢的独特性和唯一性。当我们为肺癌小数注入葡萄糖转运蛋白抑制剂的时候,鳞状细胞癌细胞数量减少,虽然没有完全根除,但是肿瘤生长的速度减缓了,反之,腺癌却没有什么明显变化。”

“这一发现为我们开发治疗鳞状亚型癌症的新方法提供了新思路,在此次试验中,我们还发现葡萄糖转运蛋白在其他四中鳞状癌症中的高表达,其中包括头部,颈部,食管和颈椎,这些癌症虽然位于身体不同的器官中,但是它们对糖的依赖却是不谋而合的,接下来我们就要解决这一难题,找到治疗鳞状癌症的新方法。”

原始出处:

Justin Goodwin, Michael L. Neugent, Shin Yup Lee, et al. The distinct metabolic phenotype of lung squamous cell carcinoma defines selective vulnerability to glycolytic inhibition. Nature Communications 8, Article number: 15503 (2017). doi:10.1038/ncomms15503

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    2018-04-06 liye789132251
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topicList=[TopicDto(id=5019, encryptionId=490750196b, topicName=COMMUN)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7931272, createdName=liuli5079, createdTime=Sat Feb 10 00:39:00 CST 2018, time=2018-02-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=210877, encodeId=f2152108e709, content=谢谢分享,学习了!, beContent=null, objectType=article, channel=null, level=null, likeNumber=57, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/ajNVdqHZLLC1BMzZWdMSPQWuib6BtQGicK8ygGBM6YakpfkRc67soFSuKbZr86enL1KggQZEZbgWSeicJibafmYfQ3AibicIHMwwicmDShfRFvvI38/0, createdBy=272a110164, createdName=laoli, createdTime=Thu Jun 15 06:22:54 CST 2017, time=2017-06-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=204010, encodeId=1189204010b7, content=虽然说是高依赖葡萄糖,但是又不是像肝细胞那样有糖浓度的依赖性,所以想从这方面下手,还是很难吧,必竟是最普用的能源物质, beContent=null, objectType=article, channel=null, level=null, likeNumber=61, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/04/29/9400cebba4f37a94e50b94f61c58b1ae.jpg, createdBy=f0222049955, createdName=?, createdTime=Mon May 29 12:27:56 CST 2017, time=2017-05-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=203908, encodeId=cbca2039086d, content=以后甜食要少吃,养成良好生活习惯,感谢, beContent=null, objectType=article, channel=null, level=null, likeNumber=50, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160907/IMG57D00CF1965701770.jpg, createdBy=565c1948251, createdName=舒心和人, createdTime=Mon May 29 08:03:38 CST 2017, time=2017-05-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1252256, encodeId=4b90125225630, content=<a href='/topic/show?id=3efee1519b2' target=_blank style='color:#2F92EE;'>#癌细胞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=71519, encryptionId=3efee1519b2, topicName=癌细胞)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4cea26, createdName=yxch36, createdTime=Mon May 29 00:39:00 CST 2017, time=2017-05-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=203593, encodeId=90be20359388, content=涨知识了,鳞状细胞爱最依赖葡萄糖,谢E, beContent=null, objectType=article, channel=null, level=null, likeNumber=56, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=550d2008262, createdName=luominglian113, createdTime=Sun May 28 13:28:55 CST 2017, time=2017-05-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=203200, encodeId=12e720320011, content=学习了,又涨知识了!, beContent=null, objectType=article, channel=null, level=null, likeNumber=46, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160914/IMG57D82E721DB581755.jpg, createdBy=4fc81933929, createdName=明天会更好!, createdTime=Sat May 27 11:19:41 CST 2017, time=2017-05-27, status=1, ipAttribution=)]
    2018-02-10 liuli5079
  5. 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target=_blank style='color:#2F92EE;'>#癌细胞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=71519, encryptionId=3efee1519b2, topicName=癌细胞)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4cea26, createdName=yxch36, createdTime=Mon May 29 00:39:00 CST 2017, time=2017-05-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=203593, encodeId=90be20359388, content=涨知识了,鳞状细胞爱最依赖葡萄糖,谢E, beContent=null, objectType=article, channel=null, level=null, likeNumber=56, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=550d2008262, createdName=luominglian113, createdTime=Sun May 28 13:28:55 CST 2017, time=2017-05-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=203200, encodeId=12e720320011, content=学习了,又涨知识了!, beContent=null, objectType=article, channel=null, level=null, likeNumber=46, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160914/IMG57D82E721DB581755.jpg, createdBy=4fc81933929, createdName=明天会更好!, createdTime=Sat May 27 11:19:41 CST 2017, time=2017-05-27, status=1, ipAttribution=)]
    2017-06-15 laoli

    谢谢分享,学习了!

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=1882099, encodeId=2fe418820993d, content=<a href='/topic/show?id=3b2112532d8' target=_blank style='color:#2F92EE;'>#Nat#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12532, encryptionId=3b2112532d8, topicName=Nat)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=2e6f107, createdName=liye789132251, createdTime=Fri Apr 06 15:39:00 CST 2018, time=2018-04-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1665017, encodeId=0673166501e92, content=<a href='/topic/show?id=c8664008e1a' target=_blank style='color:#2F92EE;'>#喂养#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=40087, encryptionId=c8664008e1a, topicName=喂养)], attachment=null, authenticateStatus=null, createdAvatar=null, 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topicList=[TopicDto(id=5019, encryptionId=490750196b, topicName=COMMUN)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7931272, createdName=liuli5079, createdTime=Sat Feb 10 00:39:00 CST 2018, time=2018-02-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=210877, encodeId=f2152108e709, content=谢谢分享,学习了!, beContent=null, objectType=article, channel=null, level=null, likeNumber=57, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/ajNVdqHZLLC1BMzZWdMSPQWuib6BtQGicK8ygGBM6YakpfkRc67soFSuKbZr86enL1KggQZEZbgWSeicJibafmYfQ3AibicIHMwwicmDShfRFvvI38/0, createdBy=272a110164, createdName=laoli, createdTime=Thu Jun 15 06:22:54 CST 2017, time=2017-06-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=204010, encodeId=1189204010b7, content=虽然说是高依赖葡萄糖,但是又不是像肝细胞那样有糖浓度的依赖性,所以想从这方面下手,还是很难吧,必竟是最普用的能源物质, beContent=null, objectType=article, 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target=_blank style='color:#2F92EE;'>#癌细胞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=71519, encryptionId=3efee1519b2, topicName=癌细胞)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4cea26, createdName=yxch36, createdTime=Mon May 29 00:39:00 CST 2017, time=2017-05-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=203593, encodeId=90be20359388, content=涨知识了,鳞状细胞爱最依赖葡萄糖,谢E, beContent=null, objectType=article, channel=null, level=null, likeNumber=56, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=550d2008262, createdName=luominglian113, createdTime=Sun May 28 13:28:55 CST 2017, time=2017-05-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=203200, encodeId=12e720320011, content=学习了,又涨知识了!, beContent=null, objectType=article, channel=null, level=null, likeNumber=46, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160914/IMG57D82E721DB581755.jpg, createdBy=4fc81933929, createdName=明天会更好!, createdTime=Sat May 27 11:19:41 CST 2017, time=2017-05-27, status=1, ipAttribution=)]
    2017-05-29

    虽然说是高依赖葡萄糖,但是又不是像肝细胞那样有糖浓度的依赖性,所以想从这方面下手,还是很难吧,必竟是最普用的能源物质

    0

  7. 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topicList=[TopicDto(id=5019, encryptionId=490750196b, topicName=COMMUN)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7931272, createdName=liuli5079, createdTime=Sat Feb 10 00:39:00 CST 2018, time=2018-02-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=210877, encodeId=f2152108e709, content=谢谢分享,学习了!, beContent=null, objectType=article, channel=null, level=null, likeNumber=57, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/ajNVdqHZLLC1BMzZWdMSPQWuib6BtQGicK8ygGBM6YakpfkRc67soFSuKbZr86enL1KggQZEZbgWSeicJibafmYfQ3AibicIHMwwicmDShfRFvvI38/0, createdBy=272a110164, createdName=laoli, createdTime=Thu Jun 15 06:22:54 CST 2017, time=2017-06-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=204010, encodeId=1189204010b7, content=虽然说是高依赖葡萄糖,但是又不是像肝细胞那样有糖浓度的依赖性,所以想从这方面下手,还是很难吧,必竟是最普用的能源物质, beContent=null, objectType=article, 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target=_blank style='color:#2F92EE;'>#癌细胞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=71519, encryptionId=3efee1519b2, topicName=癌细胞)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4cea26, createdName=yxch36, createdTime=Mon May 29 00:39:00 CST 2017, time=2017-05-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=203593, encodeId=90be20359388, content=涨知识了,鳞状细胞爱最依赖葡萄糖,谢E, beContent=null, objectType=article, channel=null, level=null, likeNumber=56, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=550d2008262, createdName=luominglian113, createdTime=Sun May 28 13:28:55 CST 2017, time=2017-05-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=203200, encodeId=12e720320011, content=学习了,又涨知识了!, beContent=null, objectType=article, channel=null, level=null, likeNumber=46, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160914/IMG57D82E721DB581755.jpg, createdBy=4fc81933929, createdName=明天会更好!, createdTime=Sat May 27 11:19:41 CST 2017, time=2017-05-27, status=1, ipAttribution=)]
    2017-05-29 舒心和人

    以后甜食要少吃,养成良好生活习惯,感谢

    0

  8. 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target=_blank style='color:#2F92EE;'>#癌细胞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=71519, encryptionId=3efee1519b2, topicName=癌细胞)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4cea26, createdName=yxch36, createdTime=Mon May 29 00:39:00 CST 2017, time=2017-05-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=203593, encodeId=90be20359388, content=涨知识了,鳞状细胞爱最依赖葡萄糖,谢E, beContent=null, objectType=article, channel=null, level=null, likeNumber=56, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=550d2008262, createdName=luominglian113, createdTime=Sun May 28 13:28:55 CST 2017, time=2017-05-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=203200, encodeId=12e720320011, content=学习了,又涨知识了!, beContent=null, objectType=article, channel=null, level=null, likeNumber=46, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160914/IMG57D82E721DB581755.jpg, createdBy=4fc81933929, createdName=明天会更好!, createdTime=Sat May 27 11:19:41 CST 2017, time=2017-05-27, status=1, ipAttribution=)]
    2017-05-29 yxch36
  9. [GetPortalCommentsPageByObjectIdResponse(id=1882099, encodeId=2fe418820993d, content=<a href='/topic/show?id=3b2112532d8' target=_blank style='color:#2F92EE;'>#Nat#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12532, encryptionId=3b2112532d8, topicName=Nat)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=2e6f107, createdName=liye789132251, createdTime=Fri Apr 06 15:39:00 CST 2018, time=2018-04-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1665017, encodeId=0673166501e92, content=<a href='/topic/show?id=c8664008e1a' target=_blank style='color:#2F92EE;'>#喂养#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=40087, encryptionId=c8664008e1a, topicName=喂养)], attachment=null, authenticateStatus=null, createdAvatar=null, 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channel=null, level=null, likeNumber=46, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160914/IMG57D82E721DB581755.jpg, createdBy=4fc81933929, createdName=明天会更好!, createdTime=Sat May 27 11:19:41 CST 2017, time=2017-05-27, status=1, ipAttribution=)]
    2017-05-28 luominglian113

    涨知识了,鳞状细胞爱最依赖葡萄糖,谢E

    0

  10. 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channel=null, level=null, likeNumber=46, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160914/IMG57D82E721DB581755.jpg, createdBy=4fc81933929, createdName=明天会更好!, createdTime=Sat May 27 11:19:41 CST 2017, time=2017-05-27, status=1, ipAttribution=)]
    2017-05-27 明天会更好!

    学习了,又涨知识了!

    0

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近年来,全基因组测序技术的发展为科学家们在癌症等多种疾病上的研究提供了巨大的帮助,在全基因组测序的帮助下,科学家们就能够有效鉴别出和癌症相关的基因突变,为开发靶向性的癌症新型疗法提供了一定希望,那么全基因组测序研究的进展如何呢?本文中,小编对近年来全基因组测序进展的相关研究进行了整理,分享给各位! 【1】AJHG:科学家利用全基因测序来鉴别个体的患病风险 doi:10.1016/j.

**癌症专家:独门绝学造就精准免疫疗法

编者按:Daniel O'Connor 博士在生物医药行业是一名资深老兵。这名顶尖癌症专家有超过 20 年的丰富经验,工作涵盖执行、法务与监管等多个领域,可谓是多面手。先前,他曾任 ImClone Systems 公司高级副总裁、董事会总顾问和秘书,参与抗癌药物 ERBITUX?的研发上市。值得一提的是,这也是首款经美国 FDA 获批治疗头颈部癌的单克隆抗体。如今,Daniel O'C

British J Cancer:大肚子的人更容易得癌症?

根据最近发表在《British Journal of Cancer》杂志上的一篇文章,科学家们发现了身体中部囤积的脂肪可以用于预测癌症发生的风险。结果显示,腰围每增加11厘米,患肥胖症相关癌症的风险将提高13%。对于肠癌来说,腰围每增加8厘米即伴随着患癌风险15%的提升。 身体乘载过多的脂肪会改变性激素的分泌水平,例如雌二醇以及睾酮等,进而引

Science:科学家在癌细胞中安装“刹车”,有力控制癌细胞疯长!

癌症虽然是一种极其复杂的疾病,但是它的定义却相当简单,那就是异常和不可控的细胞的增长。罗彻斯特大学RNA生物学中心的研究人员们已经确定了一种减缓癌细胞疯长的新科技,这种方法适用于所有类型的癌症。报告结果发表于今天的《科学》杂志上,此次研究由美国国立卫生研究院资助。虽然还有很长一段路要走,但是这一科技无疑为今后的治疗指明了方向。

PNAS:当癌症来敲门,结构生物学不是稻草而是救生器材

癌症降临,身体中的许多细胞都已经出现了问题。找出癌症的关键,才能捋清事实,指引出路。基因开关正是这团乱麻般的细胞变异的核心。“人类许多疾病的产生都是由于基因开关发生了故障,”加州理工大学传统医学研究所研究员André Hoelz说。“在原子层面阐明它们的工作机理,才能让我们看清如何定制药物可使它们失活,在许多情况下,这是走向治愈的关键步骤。”急性髓系白血病(AML)是一种极具攻击性的癌症,有一个基

Science:让所有类型癌细胞都减缓生长的方法

5月26日的Science上发表了Rochester大学研究人员发现的一种新方法,可以减缓所有类型癌症细胞的快速生长特征。该方法通过靶向Tudor-SN蛋白能够抑制快速增长的癌细胞,已经在实验室中进行了肾癌和宫颈癌细胞的研究。