JAHA:不良妊娠结局与中年血压和亚临床血管指标的关系!

2017-12-30 xing.T MedSci原创

结果表明,PTB病史与中年后期较高的BP和平均动脉压相关。当将高血压患者排除后,不良妊娠结局与亚临床心血管疾病无关。未来针对绝经后过渡期的研究对于评估不良妊娠结局对中年血压进展的影响是很重要的。

不良妊娠结局,如早产(PTB),已被证实与较高的母体心血管疾病风险相关联,但它们对中年后期血压(BP)和亚临床血管指标的的影响仍不清楚。

近日,心血管疾病领域权威杂志JAHA上发表了一篇研究文章。研究人员对1220名参与全国妇女健康研究(SWAN)多民族的经产妇女进行了一项横截面分析旨在评价自我报告的不良妊娠结局史(PTB、小于胎龄儿、死胎)对产妇中年后期血压、平均动脉压和亚临床血管指标(颈动脉内膜中层厚度、斑块和脉搏波速度)的影响。研究人员还评估了这些相关性是否被种族/民族所改变。这些相关性是在调整了社会人口统计指标、生殖因素、心血管危险因素和药物治疗后的线性和logistic回归模型中进行分析。

妇女平均年龄为60岁,255名妇女报告有不良妊娠结局。在充分调整的模型中,PTB史与较高的BP相关(收缩压:β= 6.40;SE为1.62[P<0.0001],舒张压:β=3.18;SE为0.98 [P=0.001])和平均动脉压(β=4.55;SE为1.13[P<0.0001])。PTB与较低的内膜中层厚度有关,但在排除患高血压的妇女后无关。与其他亚临床血管指标也无显著关联。

结果表明,PTB病史与中年后期较高的BP和平均动脉压相关。当将高血压患者排除后,不良妊娠结局与亚临床心血管疾病无关。未来针对绝经后过渡期的研究对于评估不良妊娠结局对中年血压进展的影响是很重要的。

原始出处:

Yamnia I. Cortés,et al. History of Adverse Pregnancy Outcomes, Blood Pressure, and Subclinical Vascular Measures in Late Midlife: SWAN (Study of Women's Health Across the Nation).JAHA.2017. https://doi.org/10.1161/JAHA.117.007138

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    2018-01-03 lou.minghong

    研究对象平均年龄60岁!

    0

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    2018-01-01 zhaohui6731
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    2017-12-30 lovetcm

    研究的样本量太小

    0

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