Blood:增强子活化和染色质聚散是原发性多发性骨髓瘤的调控网络

2018-03-10 MedSci MedSci原创

多发性骨髓瘤(MM)是一种起源于分泌抗体的浆细胞的侵袭性癌症。虽然现对其相关遗传和转录的特性已获得很好的了解,但该疾病相关的异常基因网络尚未得到充分的认识。现有研究人员在原发性MM细胞中绘制了调控元件、解旋的染色质和转录因子足迹。与分泌正常抗体的细胞相比,MM细胞表现为增强子活性持续改变,与超级增强子(SE)介导的转录因子(TF)基因异常调节相关。MM细胞还出现广泛的异染色质松散,与调控元件激活和

多发性骨髓瘤(MM)是一种起源于分泌抗体的浆细胞的侵袭性癌症。虽然现对其相关遗传和转录的特性已获得很好的了解,但该疾病相关的异常基因网络尚未得到充分的认识。

现有研究人员在原发性MM细胞中绘制了调控元件、解旋的染色质和转录因子足迹。与分泌正常抗体的细胞相比,MM细胞表现为增强子活性持续改变,与超级增强子(SE)介导的转录因子(TF)基因异常调节相关。MM细胞还出现广泛的异染色质松散,与调控元件激活和部分患者的cAMP信号通路调控异常相关。最后,建立与SE相关的以TF为基础的调控网络可帮助识别一些对MM生物学至关重要的新的TFs。

总而言之,本研究显著促进了我们对MM的异常基因调控网络的了解。

原始出处:

Ji Jin,et al.Active enhancer and chromatin accessibility landscapes chart the regulatory network of primary multiple myeloma.Blood  2018  :blood-2017-09-808063;  doi: https://doi.org/10.1182/blood-2017-09-808063

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    2018-05-31 jml2009
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    2018-10-24 tulenzi
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    2018-03-10 清风拂面

    谢谢分享学习

    0

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    2018-03-10 329523732

    不错

    0

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多发性骨髓瘤的特点是产生单克隆的副蛋白和溶骨性病变,常导致骨骼相关的症状(脊髓受压,病理性骨折,或手术或放射治疗影响骨)。狄诺塞麦(denosumab),一种靶向RANKL的单克隆抗体,可减轻晚期实体肿瘤患者骨溶解或骨转移相关的骨症状。本研究旨在评估狄诺塞麦与唑来膦酸相比,用于新确诊的多发性骨髓瘤患者预防其骨骼相关症状的效果和安全性。在多个国家的多个中心开展一国际性的双盲双模拟的随机化活性对照的3

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克隆演变是指不同时间点的肿瘤克隆的异质性变化,治疗前可能某种克隆占优势,同时存在其它亚克隆,肿瘤缓解后克隆结构发生变化,复发后可能原有的次要克隆变成优势克隆或是出现一种既往没有的新克隆,这些都称为克隆演变。

NCCN临床实践指南:多发性骨髓瘤(2018.V4)

2018年2月,美国国家综合癌症网络(NCCN)发布了多发性骨髓瘤实践指南2018年第4版,指南主要内容涉及: 指南更新摘要 多发性骨髓瘤最初诊断和临床表现 孤立性浆细胞瘤初级治疗 多发性骨髓瘤初级治疗和随访/监测 活动性骨髓瘤随访/监测 干细胞移植术后治疗 活动性疾病:复发或进展性疾病的附加治疗 多发性骨髓瘤的定义 分期 多发性骨髓瘤的反应标准 骨髓瘤的治疗 辅助治疗

多发性骨髓瘤患者很需要知道的N件事!

多发性骨髓瘤是一种常见的恶性浆细胞疾病,源自于骨髓中单克隆增生的浆细胞,近些年来其发病率呈逐步递增的趋势,这与人口老龄化及检出率增多密切相关。