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Sci Rep：淫羊藿苷可有效修复骨缺损

2017-09-06 MedSci MedSci原创

淫羊藿苷骨缺损
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通常，骨再生医学应用于骨质疏松症患者的骨缺损修复。同时，迫切需要开发安全、廉价的诱导骨形成的药物。研究发现淫羊藿苷（淫羊藿的主要活性成分）可促进体外成骨细胞的增殖。然而，淫羊藿苷能否修复骨质疏松引起的骨缺损目前尚不清楚。本实验中，研究人员首先建立了大鼠骨质疏松模型，然后评价淫羊藿苷处理的骨髓间充质干细胞(BMSCs)的成骨分化和血管生成分化的效果。此外，研究人员还构建了含淫羊藿苷的磷酸钙骨水泥支架

通常，骨再生医学应用于骨质疏松症患者的骨缺损修复。同时，迫切需要开发安全、廉价的诱导骨形成的药物。研究发现淫羊藿苷（淫羊藿的主要活性成分）可促进体外成骨细胞的增殖。然而，淫羊藿苷能否修复骨质疏松引起的骨缺损目前尚不清楚。

本实验中，研究人员首先建立了大鼠骨质疏松模型，然后评价淫羊藿苷处理的骨髓间充质干细胞(BMSCs)的成骨分化和血管生成分化的效果。此外，研究人员还构建了含淫羊藿苷的磷酸钙骨水泥支架，并将其植入裸鼠体内，以确定最佳结构。为了评价淫羊藿苷体内成骨和血管生成的能力，研究人员使用淫羊藿苷灌胃处理去势（OVX）伴颅骨缺损的大鼠。

结果显示，淫羊藿甙能调节BMSCs成骨和血管生成基因的表达。同时，破骨细胞的形成受到抑制。

总之，本研究结果表明，CPC可作为缓释淫羊藿苷的载体系统，通过增强成骨和血管生成来修复骨缺损。淫羊藿苷全身给药可促进骨缺损的修复具有抗骨质疏松的效果。

原始出处：

Yuqiong Wu, LingYan Cao, et al., Evaluation of Osteogenesis and Angiogenesis of Icariin in Local Controlled Release and Systemic Delivery for Calvarial Defect in Ovariectomized Rats. Sci Rep. 2017; 7: 5077. Published online 2017 Jul 11. doi: 10.1038/s41598-017-05392-z

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    2018-06-06 tidiq

    #淫羊藿苷#

    0

  2. 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    2017-09-14 雅文博武

    学习了很多先进的医疗技术

    0

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2017, time=2017-09-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=241065, encodeId=dee724106535, content=学习了.谢谢., beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/xkvRjYnJzzRJ2R0y7VhicibvkjPWHjIMmu4ZpKnE9cWAu4lVicS3uDUCfF4M4JWvrkrYfpb2KehPV0Ee29tPqyPEebBUibiaKhnvD/0, createdBy=f8412001184, createdName=惠映实验室, createdTime=Wed Sep 06 14:54:53 CST 2017, time=2017-09-06, status=1, ipAttribution=)]
    2017-09-11 wxl882001

    学习一下

    0

  4. 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2017, time=2017-09-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=241065, encodeId=dee724106535, content=学习了.谢谢., beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/xkvRjYnJzzRJ2R0y7VhicibvkjPWHjIMmu4ZpKnE9cWAu4lVicS3uDUCfF4M4JWvrkrYfpb2KehPV0Ee29tPqyPEebBUibiaKhnvD/0, createdBy=f8412001184, createdName=惠映实验室, createdTime=Wed Sep 06 14:54:53 CST 2017, time=2017-09-06, status=1, ipAttribution=)]
    2017-09-08 chunjianf

    学习了.谢谢分享

    0

  5. 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2017, time=2017-09-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=241065, encodeId=dee724106535, content=学习了.谢谢., beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/xkvRjYnJzzRJ2R0y7VhicibvkjPWHjIMmu4ZpKnE9cWAu4lVicS3uDUCfF4M4JWvrkrYfpb2KehPV0Ee29tPqyPEebBUibiaKhnvD/0, createdBy=f8412001184, createdName=惠映实验室, createdTime=Wed Sep 06 14:54:53 CST 2017, time=2017-09-06, status=1, ipAttribution=)]
    2017-09-08 lfcmxl

    #骨缺损#

    0

  6. 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2017, time=2017-09-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=241065, encodeId=dee724106535, content=学习了.谢谢., beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/xkvRjYnJzzRJ2R0y7VhicibvkjPWHjIMmu4ZpKnE9cWAu4lVicS3uDUCfF4M4JWvrkrYfpb2KehPV0Ee29tPqyPEebBUibiaKhnvD/0, createdBy=f8412001184, createdName=惠映实验室, createdTime=Wed Sep 06 14:54:53 CST 2017, time=2017-09-06, status=1, ipAttribution=)]
    2017-09-08 wenjie

    #淫羊藿#

    0

  7. 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2017, time=2017-09-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=241065, encodeId=dee724106535, content=学习了.谢谢., beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/xkvRjYnJzzRJ2R0y7VhicibvkjPWHjIMmu4ZpKnE9cWAu4lVicS3uDUCfF4M4JWvrkrYfpb2KehPV0Ee29tPqyPEebBUibiaKhnvD/0, createdBy=f8412001184, createdName=惠映实验室, createdTime=Wed Sep 06 14:54:53 CST 2017, time=2017-09-06, status=1, ipAttribution=)]
    2017-09-07 hfuym10906

    学习了学习了学习了学习了学习了学习了学习了学习了学习了

    0

  8. 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2017, time=2017-09-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=241065, encodeId=dee724106535, content=学习了.谢谢., beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/xkvRjYnJzzRJ2R0y7VhicibvkjPWHjIMmu4ZpKnE9cWAu4lVicS3uDUCfF4M4JWvrkrYfpb2KehPV0Ee29tPqyPEebBUibiaKhnvD/0, createdBy=f8412001184, createdName=惠映实验室, createdTime=Wed Sep 06 14:54:53 CST 2017, time=2017-09-06, status=1, ipAttribution=)]
    2017-09-06 changjiu

    学习了.谢谢

    0

  9. 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2017, time=2017-09-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=241065, encodeId=dee724106535, content=学习了.谢谢., beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/xkvRjYnJzzRJ2R0y7VhicibvkjPWHjIMmu4ZpKnE9cWAu4lVicS3uDUCfF4M4JWvrkrYfpb2KehPV0Ee29tPqyPEebBUibiaKhnvD/0, createdBy=f8412001184, createdName=惠映实验室, createdTime=Wed Sep 06 14:54:53 CST 2017, time=2017-09-06, status=1, ipAttribution=)]
    2017-09-06 sunfeifeiyang

    阅

    0

  10. 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GetPortalCommentsPageByObjectIdResponse(id=241088, encodeId=12c5241088f8, content=学习了.谢谢, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zSn0GqHrsfLGSUSR8zwnWWLT4FMl5XH8S58HuZslVkLsAPbXDXaliagK7TOxQfmngKibG1yrDonepCLDkcxGk8hS/0, createdBy=b8282062892, createdName=changjiu, createdTime=Wed Sep 06 16:37:22 CST 2017, time=2017-09-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=241069, encodeId=024e2410691f, content=阅, beContent=null, objectType=article, channel=null, level=null, likeNumber=22, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/09/07/a9772c74ffd6edc03a7f9af07b4747f6.jpg, createdBy=b3722138742, createdName=sunfeifeiyang, createdTime=Wed Sep 06 15:03:49 CST 2017, time=2017-09-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=241065, encodeId=dee724106535, content=学习了.谢谢., beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/xkvRjYnJzzRJ2R0y7VhicibvkjPWHjIMmu4ZpKnE9cWAu4lVicS3uDUCfF4M4JWvrkrYfpb2KehPV0Ee29tPqyPEebBUibiaKhnvD/0, createdBy=f8412001184, createdName=惠映实验室, createdTime=Wed Sep 06 14:54:53 CST 2017, time=2017-09-06, status=1, ipAttribution=)]
    2017-09-06 惠映实验室

    学习了.谢谢.

    0

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