Diabetes Care:1型和2型糖尿病青年周围神经病变患病率及危险因素!

2017-07-04 xing.T MedSci原创

由此可见,青年糖尿病患者DPN的高发病率是引起关注的原因,并建议进行早期筛查和更好的风险因素管理。解决血糖控制不良和血脂异常对年轻人干预可以预防或延缓导致神经病变的并发症。

近日,糖尿病领域权威杂志Diabetes Care上发表了一研究文章,研究人员旨在评估被招募入糖尿病SEARCH青年研究的1型糖尿病(T1DM)和2型糖尿病(T2DM)青少年糖尿病周围神经病变(DPN)的患病率和危险因素。

密歇根神经病变筛查工具(MNSI)被用来评估1734名青年T1DM(年龄为18±4岁,TIDM病程持续7.2±1.2年,糖化血红蛋白为9.1±1.9%)和258名青年T2DM患者(年龄为22±3.5岁,糖尿病病程持续为7.9±2年,糖化血红蛋白为9.4±2.3%)的DPN,这些患者被招募入SEARCH研究,并且糖尿病病程≥5年。DPN定义为MNSI评估分数>2。随着时间的推移血糖控制被估计为糖化血红蛋白的曲线下面积。

在T1DM青年患者中DPN的患病率为7%,在T2DM青年患者中DPN的患病率为22%,T1DM青年DPN的危险因素包括年龄较大、糖尿病病程较长、吸烟、舒张压增高、肥胖、低密度脂蛋白胆固醇和甘油三酯升高以及较低的高密度脂蛋白胆固醇(HDL-C)。在T2DM青年中,危险因素包括年龄较大、男性、糖尿病病程较长、吸烟、较低的HDL-C。随着时间推移的血糖控制在那些TIDM青年的DPN患者中更糟糕,相比于那些没有DPN的T1DM青年(比值比为1.53,95%可信区间为1.24-1.88)但T2DM青年患者中并不存在(1.05[0.7-1.56])。

由此可见,青年糖尿病患者DPN的高发病率是引起关注的原因,并建议进行早期筛查和更好的风险因素管理。解决血糖控制不良和血脂异常对年轻人干预可以预防或延缓导致神经病变的并发症。

原始出处:

Mamta Jaiswal,et al. Prevalence of and Risk Factors for Diabetic Peripheral Neuropathy in Youth With Type 1 and Type 2 Diabetes: SEARCH for Diabetes in Youth Study.Diabetes Care 2017. https://doi.org/10.2337/dc17-0179

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    2017-07-06 axin012
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    2017-07-04 1e0f8808m18(暂无匿称)

    糖尿病周围神经病变是糖尿病常见并发症

    0

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    2017-07-04 清风拂面

    谢谢分享,学习了

    0

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