Am Heart J:心理状态能否预测胸痛复发?

2017-09-25 安雅晶 环球医学

2017年9月,发表在《Am Heart J》的一项由美国科学家进行的急诊的前瞻性队列研究表明,抑郁与胸痛复发伴或不伴冠状动脉疾病相关。

2017年9月,发表在《Am Heart J》的一项由美国科学家进行的急诊的前瞻性队列研究表明,抑郁与胸痛复发伴或不伴冠状动脉疾病相关。

背景:急诊中,只有一小部分急性胸痛因阻塞性冠状动脉疾病(CAD)造成。急诊胸痛存在较高的复发率,常发生于非阻塞性CAD。心理状态,如抑郁、焦虑、感知压力升高等,可能能够解释这一结果。本研究的目的为确定心理状态是否可以预测胸痛复发(RCP)。

方法:研究者进行了一项前瞻性队列研究,研究对象为低~中等心脏风险的急诊患者,这些患者因急性胸痛入住到耶鲁胸痛中心。使用多研究验证的筛查量表评估了每位患者的抑郁、焦虑和感知压力:患者健康调查问卷(PHQ8)、临床焦虑量表(CAS)、感知压力量表(PSS)。所有因梗死而排除的患者都进行了合适的心脏压力测试。首要结局为30天时电话随访和病历记录评估的RCP。每个心理量表和RCP之间的相关性都使用有序logistic回归进行评估,并调整了已知的社会人口学和心脏风险因素。抑郁(PHQ8≥10)、焦虑(CAS≥30)、感知压力(PSS≥15)认为是阳性。

结果:2013年8月~2015年5月,985名患者在耶鲁胸痛中心进行筛查。入组的500名患者中,483人具有完整的数据,365人(76%)完成了随访。36%(131人)在1个月内RCP。多变量回归模型中,抑郁(OR,2.11;95% CI,1.18~3.79)为30天胸痛复发的显着性独立预测因素,而PSS(0.96;0.60~1.53)和焦虑(1.59;0.80~3.20)不是。相似的,抑郁的心理评估(通过PHQ8)和胸痛频率之间具有直接的相关性。

结论:抑郁与RCP独立相关,不管压力测试是否显示为显着的心肌缺血。识别和靶向干预可能会减少RCP复发。

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    2017-09-27 zhaojie88
  3. [GetPortalCommentsPageByObjectIdResponse(id=1758548, encodeId=95b01e5854867, content=<a href='/topic/show?id=0901511e083' target=_blank style='color:#2F92EE;'>#心理状态#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=19, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=51170, encryptionId=0901511e083, topicName=心理状态)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ca7137331475, createdName=肉我只吃一口, createdTime=Mon Oct 09 22:12:00 CST 2017, time=2017-10-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1356515, encodeId=702c135651554, content=<a href='/topic/show?id=b0702e84b9' target=_blank style='color:#2F92EE;'>#ART#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2784, encryptionId=b0702e84b9, topicName=ART)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=zhaojie88, createdTime=Wed Sep 27 06:12:00 CST 2017, time=2017-09-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1562700, encodeId=11251562e000a, content=<a href='/topic/show?id=f69d864413' target=_blank style='color:#2F92EE;'>#HEART#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=8644, encryptionId=f69d864413, topicName=HEART)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=80d715270048, createdName=slcumt, createdTime=Wed Sep 27 06:12:00 CST 2017, time=2017-09-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=247713, encodeId=1a6224e71356, content=相关关系, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/09/07/a9772c74ffd6edc03a7f9af07b4747f6.jpg, createdBy=b3722138742, createdName=sunfeifeiyang, createdTime=Tue Sep 26 00:23:07 CST 2017, time=2017-09-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=247606, encodeId=cc3524e6063d, content=急诊中.只有一小部分急性胸痛因阻塞性冠状动脉疾病(CAD)造成.急诊胸痛存在较高的复发率.常发生于非阻塞性CAD, beContent=null, objectType=article, channel=null, level=null, likeNumber=41, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7cJ6ejWUr2nIia8qOvAKNdLHr32Df6G8iaoaOx6pHaoiacwp26DaslxZHCGbibZhhCGven4rvmWP60GahtzgFjgCjR/0, createdBy=6b111703011, createdName=有备才能无患, createdTime=Mon Sep 25 15:17:48 CST 2017, time=2017-09-25, status=1, ipAttribution=)]
    2017-09-27 slcumt
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    2017-09-26 sunfeifeiyang

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    2017-09-25 有备才能无患

    急诊中.只有一小部分急性胸痛因阻塞性冠状动脉疾病(CAD)造成.急诊胸痛存在较高的复发率.常发生于非阻塞性CAD

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