Diabetes Care:2型糖尿病患者接受空肠Roux-en-Y胃旁路手术后缓解率更高

2016-07-02 MedSci MedSci原创

这项研究的目的是确定和2型糖尿病缓解相关的基线和减肥手术后的特点,是否在控制了减肥的差异后,空肠Roux-en-Y胃旁路(RYGBP)后糖尿病缓解的率要比腹腔镜胃束带手术(LAGB)后更大。研究人员使用广义线性混合模型在一项肥胖者的观察性队列中考察减肥手术类型和糖尿病缓解率的关系。在2458名肥胖者被纳入研究后,1868(76%)名参与者有完整的基线和至少一个随访时期的糖尿病状态数据可用于评估。其

这项研究的目的是确定和2型糖尿病缓解相关的基线和减肥手术后的特点,是否在控制了减肥的差异后,空肠Roux-en-Y胃旁路(RYGBP)后糖尿病缓解的率要比腹腔镜胃束带手术(LAGB)后更大。

研究人员使用广义线性混合模型在一项肥胖者的观察性队列中考察减肥手术类型和糖尿病缓解率的关系。在2458名肥胖者被纳入研究后,1868(76%)名参与者有完整的基线和至少一个随访时期的糖尿病状态数据可用于评估。其中,627名参与者(34%)被归类为糖尿病:466例接受RYGBP,140例接受LAGB。

3年后,68.7%的RYGBP和30.2%的LAGB参与者有糖尿病缓解。与糖尿病相关的缓解基线因素包括接受LAGB手术时体重较低,空腹C肽更高,接受RYGBP时瘦素与脂肪质量比更低,以及两项手术无需胰岛素的更低的血红蛋白A1c。这两项手术后,术后体重下降越多,缓解率越高。然而,即使在控制了体重下降量的差异后,RYGBP后的相对糖尿病缓解率依然比LAGB高了近两倍。

在近3年时,RYGBP和LAGB后糖尿病缓解率比术后减重比例更高。然而,RYGBP比LAGB手术后糖尿病缓解有两倍更多的减肥调整的可能性,这表明RYGBP后有助于改善糖代谢超出了减肥的独特机制。

原始出处:

Jonathan Q. Purnell,Faith Selzer,Abdus S. Wahed,et al.Type 2 Diabetes Remission Rates After Laparoscopic Gastric Bypass and Gastric Banding,Diabetes Care,2016.7.2

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