J Gastroenterology:连锁彩色成像可以通过与周围胃肠化生组织的高颜色对比增强对早期胃癌的识别

2018-10-13 MedSci MedSci原创

连锁彩色成像(LCI)增加了早期胃癌的诊断率,这与紫色粘膜的特征性发现有关。早期胃癌的病变存在于慢性胃炎和周围粘膜区域。本研究的目的是使用LCI通过颜色差异和颜色成分值客观地表征这些病变组织。

背景
连锁彩色成像(LCI)增加了早期癌的诊断率,这与紫色粘膜的特征性发现有关。早期癌的病变存在于慢性胃炎和周围粘膜区域。本研究的目的是使用LCI通过颜色差异和颜色成分值客观地表征这些病变组织。

方法
研究人员招募了52名患有早期胃癌的患者。在恶性病变和邻近粘膜中使用LCI计算颜色差异,并与切除的标本中的组织学发现进行比较。在慢性胃炎区域中比较L*,a*和b*的颜色分量值在紫色和非紫色粘膜的差异。

结果
研究人员发现74%的病变中的癌症和周围粘膜使用白光成像(WLI)具有相似的颜色,而紫色粘膜使用LCI包围部分,呈现橙红色,橙色或橙白色。与WLI相比,使用LCI可以看到更大的色差,包括扁平型癌症。周围的紫色粘膜在组织学上与肠上皮化生相对应,有助于鉴别恶性病变。在慢性胃炎区域,40个病灶(83%)有紫色粘膜,8个病灶(17%)有非紫色粘膜,通过活组织检查诊断为肠上皮化生(准确率为83%)。紫色粘膜的颜色成分值与非紫色粘膜的颜色成分值显着不同。

结论
与WLI相比,LCI图像在早期胃癌和周围粘膜之间具有更高的颜色对比度。使用LCI检查发现胃癌周围的特征性紫色代表肠上皮化生的发生。

原始出处:

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    2019-02-15 许安
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    2018-10-15 楚钟

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