PLoS One:房颤患者应用质子泵抑制剂或增急性心衰风险

2017-05-22 岱西 中国循环杂志

来自葡萄牙的一项研究显示,质子泵抑制剂增加房颤患者近3倍急性心衰住院风险。该研究随访1年时,使用质子泵抑制剂的房颤患者因急性心衰住院率为23%,而不使用的者为8%,二者有显着差异。在校正年龄、慢性肾病等因素后,那些使用质子泵抑制剂的房颤者有2.9倍急性心衰发生率。研究者指出,这可能是由于质子泵抑制剂的抑酸作用减少了铁和维生素B12的吸收,进而产生贫血,增加了心衰风险。研究者强调,房颤患者应用质子泵

来自葡萄牙的一项研究显示,质子泵抑制剂增加房颤患者近3倍急性心衰住院风险。

该研究随访1年时,使用质子泵抑制剂的房颤患者因急性心衰住院率为23%,而不使用的者为8%,二者有显着差异。

在校正年龄、慢性肾病等因素后,那些使用质子泵抑制剂的房颤者有2.9倍急性心衰发生率。

研究者指出,这可能是由于质子泵抑制剂的抑酸作用减少了铁和维生素B12的吸收,进而产生贫血,增加了心衰风险。

研究者强调,房颤患者应用质子泵抑制剂还是应该好好权衡一下利弊,尤其对于无明确适应证者要尽量避免使用。

该研究最终纳入172例初诊或复诊的房颤患者,其中有33例患者有明确的使用质子泵抑制剂的适应证,但或出于预防抗凝剂使用胃肠道出血,有53人接受了质子泵抑制剂处方。

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    2017-06-18 周周人

    学习。

    0

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    2017-05-22 cqykthl

    又有证据啦!

    0

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JAHA:抑酸治疗与心衰患者心脏死亡之间有何相关性?

由此可见,PPIs可能与心力衰竭患者更好的预后相关。

SCI TRANSL MED:中枢作用治疗减轻心衰诱发的通气过度导致的呼吸无力

只有能够穿透血脑屏障的药物才能在治疗过度通气和防止膈肌萎缩方面是有效的。这些数据对为什么类似的药物有不同的死亡和症状益处提供了解释,尽管心血管效应相当可观。

Eur Heart J:维生素D对心衰死亡率的影响!

由此可见,每日4000IU的维生素D补充并 没有减少晚期HF患者的死亡率却,但与需要更多的MCS植入相关。数据表明长期补充适度高剂量的维生素D值得谨慎考虑。

JAHA:慢性肾脏病患者心衰危险因素分析!

该研究表明以胱抑素C为基础的eGFR与蛋白尿相比于以肌酐为基础的eGFR可以更好地预测心衰的风险。此外,贫血、胰岛素抵抗、炎症和血糖控制不佳是慢性肾脏病患者心衰发生的独立危险因素。