J Rheumatol:早期关节炎心脏传导时间、心血管危险因素与炎症的关系

2017-04-29 xiangting MedSci原创

早期关节炎患者传导障碍患病率为12.5%,与普通人群相近,与炎症标志物的变化无关。然而,高胆固醇与QRS时间延长有关。

这项研究旨在调查早期关节炎传导障碍的发病率以及炎症和传统心血管(CV)风险因素的关系。

类风湿关节炎(RA)患者心源性猝死的风险高达2倍,可能归因于传导障碍。这种增加的风险可能于关节炎临床发作已经存在。因此,研究人员评估了480例早期关节炎患者基线时和1年后的心电图、血压、28关节疾病活动评分(DAS28)、血脂、红细胞沉降率(ESR)和C反应蛋白(CRP)水平。

传导障碍患病率为12.5%。基线时的传导时间与DAS28、ESR或CRP水平无关,并且在抗风湿治疗期间没有变化。DAS28(欧洲抗风湿联盟反应)、ESR和CRP的基线和改善与心率、血脂和血压显著相关。总胆固醇和血压升高与QRS时间增加有关。DAS改善最大和最小患者之间心率变化差7.3 bpm。

早期关节炎患者传导障碍患病率为12.5%,与普通人群相近,与炎症标志物的变化无关。然而,高胆固醇与QRS时间延长有关。因此,关节炎中CV风险管理的重点不仅仅在于治疗疾病活动,而且还应该是传统的CV风险因素。疾病活动和心率的改善之间的关系是显著的,因为这可能暗示10年CV死亡率风险差异为24%。

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    2017-05-01 lmm397
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