J Hypertens:高血压前期患者采用小剂量利尿剂降压的效果分析!

2017-12-13 xing.T MedSci原创

由此可见,低剂量利尿剂治疗增加高血压前期患者血压达到最优血压水平的概率,但这些接受治疗的大多数患者血压保持在高血压前期范围或进展为高血压。

近日,高血压领域权威杂志Journal of Hypertension上发表了一篇研究文章,研究人员旨在确定成年高血压前期患者采用小剂量利尿剂治疗应达到的最佳血压水平。

PREVER预防试验是一项随机、平行、双盲、安慰剂对照试验,研究人员在巴西21个教学医疗中心对受试者进行了18个月的随访。对1772名受试者评估了资格,730名30岁-70岁的高血压前期患者经过3个月的生活方式干预仍为达到最佳的血压水平,研究人员将这些患者随机分组,分别采用氯噻酮12.5 mg和阿米洛利2.5 mg联合治疗或安慰剂治疗,每日一次。该研究的主要结局为达到最佳血压水平参与者的百分比。

该研究共有372名受试者被随机分配接受利尿剂治疗和358名受试者接受安慰剂治疗。治疗18个月后,利尿剂组25.6%的受试者达到最佳血压值,而安慰剂组为19.3%(P<0.05)。利尿剂组相比于安慰剂组患者SBP和DBP平均净减少分别为2.8 mmHg(95%可信区间为1.1至4.5)和1.1mmHg(95%可信区间为-0.09至2.4)。在积极治疗组(74.5%)和安慰剂组(80.7%)的大多数参与者血压继续保持在高血压前期范围或进展为高血压。

由此可见,低剂量利尿剂治疗增加高血压前期患者血压达到最优血压水平的概率,但这些接受治疗的大多数患者血压保持在高血压前期范围或进展为高血压。

原始出处:

Fuchs, Flávio D.,et al. Effectiveness of low-dose diuretics for blood pressure reduction to optimal values in prehypertension: a randomized clinical trial.Journal of Hypertension. 2017. http://journals.lww.com/jhypertension/Abstract/publishahead/Effectiveness_of_low_dose_diuretics_for_blood.97563.aspx

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    2020-04-16 阿菡

    学习啦

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    2018-03-20 feather89
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  5. 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style='color:#2F92EE;'>#高血压前期#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=102662, encryptionId=ead91026621c, topicName=高血压前期)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=d1448837648, createdName=kord1985, createdTime=Thu Dec 14 21:41:00 CST 2017, time=2017-12-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=269025, encodeId=19ed269025df, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=75, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/vi_32/iaAVWEsIJUkA1ITy3uL0lhHUhyaJibWgFtH4KbJuaLbY2WUK33jgCFyoZ8Eqx7eE7hCuZhytc1C5GRrfjVXN8lYg/0, createdBy=fcb82149579, createdName=183****7028, createdTime=Wed Dec 13 07:00:30 CST 2017, time=2017-12-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=269023, encodeId=21f926902320, content=学习了.谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NfNLvzZhgPxRk75KAEKrLGic0S0IvH1aNynsEFQWiaNKdtzvtwj2kafCoPg2icYVbrfBCFiaS74X1uEiaaTTY1H9Xyem/0, createdBy=cec11614828, createdName=chunjianf, createdTime=Wed Dec 13 06:52:03 CST 2017, time=2017-12-13, status=1, ipAttribution=)]
    2017-12-24 pyaili
  6. 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  7. 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  8. 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  9. 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    2017-12-13 183****7028

    学习

    0

  10. 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    2017-12-13 chunjianf

    学习了.谢谢分享

    0

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Eur Heart J:高血压前期和空腹血糖受损与新发房颤相关吗?

即使在一个无合并症的健康亚洲人群中,高血压前期和IFG是房颤的重要危险因素。具体地说,当高血压前期,包括收缩压和舒张压,最后结合IFG,新发房颤的风险尤其是在BMI低于25 kg/m2的患者中增加。

JACC:袖带法量血压可能存在重大缺陷,或漏诊三分之二高血压前期或1级高血压

近期,在美国心脏病学会杂志(JACC)发表的一项Meta分析中,研究者汇总了74项相关研究,对比了2500多人用袖带血压和直接用导管插入肱动脉或主动脉直接测得的血压。

J Hypertens:青少年高血压前期与未来终末期肾病风险有何关系?

由此可见,无症状、健康的高血压前期青少年随后发生ESRD的风险增加2%,相比于最佳血压的青少年。