Nutrients:木兰提取物可抑制牙周炎所致的牙槽骨丧失

2020-04-06 MedSci原创 MedSci原创

在过去的几十年中,牙周炎已成为日益严重的健康问题,并引起了各种疾病。在许多研究中表明,某些提取物和复合物可以预防和治疗牙周炎。这项研究的重点是观察抑制牙龈损伤和牙槽骨丢失的效果。本研究旨在评估木兰提取

在过去的几十年中,牙周炎已成为日益严重的健康问题,并引起了各种疾病。在许多研究中表明,某些提取物和复合物可以预防和治疗牙周炎。这项研究的重点是观察抑制牙龈损伤和牙槽骨丢失的效果。本研究旨在评估木兰提取物(MBE)对大鼠结扎诱发的牙周炎的保护作用。

 

将结扎丝放置在磨牙周围8周,并施用MBE 8周。通过微计算机断层扫描(CT)分析和组织病理学检查进行测量牙龈组织损伤和牙槽骨丧失。使用商业试剂盒对血清白细胞介素1β(IL-1β),肿瘤坏死因子-α(TNF-α),环氧合酶-2(COX-2)和核因子-κB配体的受体激活剂(RANKL)水平进行了研究。确认MBE的抗牙周炎作用。

 

结果证实,结扎诱发的牙周炎导致牙龈组织损伤和牙槽骨丢失。但是,MBE治疗8周可避免牙周组织损伤,血清炎性细胞因子和RANKL水平下调。

 

总之,这些结果表明,MBE通过调节牙周炎引起的大鼠中的抗炎细胞因子,通过抑制牙龈组织破坏和牙槽骨损失而发挥抗牙周炎的作用。

 

原始出处:

 

Hae Jin LeeDong-Ryung Lee, et al., Antiperiodontitis Effects of Magnolia biondii Extract on Ligature-Induced Periodontitis in Rats. Nutrients. 2019 Apr; 11(4): 934. doi: 10.3390/nu11040934

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