老烟民可能对新冠病毒易感!成都学者研究称,ACE2不仅是2019新冠病毒受体,还促进炎症反应

2020-02-13 朱朱 文韬 中国循环杂志

2月5日,成都呼吸健康研究所李国平等在预印本平台medRxiv发表文章指出,在健康人群和有各种疾病的患者中,血管紧张素转换酶2(ACE2)的表达无明显差异,说明人群普遍易感,这与目前临床上观察到的结果一致。另外,基于吸烟者中ACE2的表达上调,研究者推断,长期吸烟者可能是新冠病毒感染的易感人群。研究还发现,健康人群与慢性气道疾病患者之间的ACE2表达没有显着差异。通过对SARS冠状病毒感染细胞中的

2月5日,成都呼吸健康研究所李国平等在预印本平台medRxiv发表文章指出,在健康人群和有各种疾病的患者中,血管紧张素转换酶2(ACE2)的表达无明显差异,说明人群普遍易感,这与目前临床上观察到的结果一致。

另外,基于吸烟者中ACE2的表达上调,研究者推断,长期吸烟者可能是新冠病毒感染的易感人群。

研究还发现,健康人群与慢性气道疾病患者之间的ACE2表达没有显着差异。

通过对SARS冠状病毒感染细胞中的ACE2进行分析,研究者发现,ACE2可能不仅仅是一个受体,它也参与感染后的调控过程,包括免疫应答、细胞因子分泌、病毒基因复制。

ACE2的过表达,还可诱导嗜中性粒细胞、NK细胞、Th17细胞、Th2细胞、Th1细胞、DC细胞、TNF-α分泌细胞的活化,增加炎症反应。

来源:Integrative Bioinformatics Analysis Provides Insight into the Molecular Mechanisms of 2019-nCoV. medRxiv, February 05, 2020.

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    2020-03-12 shanyongle
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    2020-02-13 公卫新人

    新冠肺炎,疫情何时才能消失

    0

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