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Blood：Ly6C-单核细胞存活依赖C/EBPβ。

2017-08-15 qinqiyun MedSci原创

Ly6C-单核细胞C/EBPβ表达凋亡存活
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在Cebpb-/-小鼠中，Ly6C-单核细胞因加速死亡而显着减少。C/EBPβ至少可以通过上调Csf1r来支持Ly6C-单核细胞存活。

中心点：

在Cebpb-/-小鼠中，Ly6C-单核细胞因加速死亡而显着减少。

C/EBPβ至少可以通过上调Csf1r来支持Ly6C-单核细胞存活。

摘要：

转录因子CCAAT/增强子结合蛋白β（C/EBPβ）在单核细胞/巨噬细胞中高表达。但其在单核细胞中的作用基本尚不清楚。故此，研究人员对C/EBPβ在单核细胞中的作用进行研究。

对单核细胞进一步细分发现Cebpb mRNA在骨髓Ly6C-单核细胞中的表达显著上调。相应的，Ly6C-单核细胞在Cebpb-小鼠中明显减少。骨髓嵌合体实验和Mx1-Cre-介导敲除Cebpb实验揭示在单核细胞发生过程中，细胞内源性和单核细胞特异性的对C/EBPβ的需求。

在Cebpb-/-小鼠中，Ly6C-单核细胞的周转率显着加速，其凋亡也增加。编码巨噬细胞集落刺激因子的Csf1r，在Cebpb-/-小鼠的Ly6C-单核细胞中的表达明显下调。C/EBPβ结合Csf1r的正向调控元件，促进其转录。

总之，以上结果表明C/EBPβ是Ly6C-单核细胞的存活的一个关键因子。

原始出处：

Akihiro Tamura，Hideyo Hirai，et al.C/EBPβ is required for survival of Ly6C- monocytes.Blood.August 14，2017. https：//doi.org/10.1182/blood-2017-03-772962

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  1. [GetPortalCommentsPageByObjectIdResponse(id=1780493, encodeId=51391e8049395, content=<a href='/topic/show?id=8baa389346' target=_blank style='color:#2F92EE;'>#C/EBPβ#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3893, encryptionId=8baa389346, topicName=C/EBPβ)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=82ba2500166, createdName=ms1467340776200723, createdTime=Tue Oct 17 07:34:00 CST 2017, time=2017-10-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1299109, encodeId=45ed1299109b7, content=<a href='/topic/show?id=2b85362063c' target=_blank style='color:#2F92EE;'>#单核细胞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=36206, encryptionId=2b85362063c, topicName=单核细胞)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=daa8281, createdName=雕雕, createdTime=Thu Aug 17 01:34:00 CST 2017, time=2017-08-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=233808, encodeId=e4432338086c, content=非常好的文章，学习了，很受益, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7LIiaRZTzJ3SEfiauCzTMPW7YvPPYLNJBXG9oh6Al1icq2VQQkIHWxqXehcicTS62YKJVBhxeth3wggw/0, createdBy=7ce01621306, createdName=天涯183, createdTime=Tue Aug 15 12:15:31 CST 2017, time=2017-08-15, status=1, ipAttribution=)]
    2017-10-17 ms1467340776200723

    #C/EBPβ#

    0

  2. [GetPortalCommentsPageByObjectIdResponse(id=1780493, encodeId=51391e8049395, content=<a href='/topic/show?id=8baa389346' target=_blank style='color:#2F92EE;'>#C/EBPβ#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3893, encryptionId=8baa389346, topicName=C/EBPβ)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=82ba2500166, createdName=ms1467340776200723, createdTime=Tue Oct 17 07:34:00 CST 2017, time=2017-10-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1299109, encodeId=45ed1299109b7, content=<a href='/topic/show?id=2b85362063c' target=_blank style='color:#2F92EE;'>#单核细胞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=36206, encryptionId=2b85362063c, topicName=单核细胞)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=daa8281, createdName=雕雕, createdTime=Thu Aug 17 01:34:00 CST 2017, time=2017-08-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=233808, encodeId=e4432338086c, content=非常好的文章，学习了，很受益, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7LIiaRZTzJ3SEfiauCzTMPW7YvPPYLNJBXG9oh6Al1icq2VQQkIHWxqXehcicTS62YKJVBhxeth3wggw/0, createdBy=7ce01621306, createdName=天涯183, createdTime=Tue Aug 15 12:15:31 CST 2017, time=2017-08-15, status=1, ipAttribution=)]
    2017-08-17 雕雕

    #单核细胞#

    0

  3. [GetPortalCommentsPageByObjectIdResponse(id=1780493, encodeId=51391e8049395, content=<a href='/topic/show?id=8baa389346' target=_blank style='color:#2F92EE;'>#C/EBPβ#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3893, encryptionId=8baa389346, topicName=C/EBPβ)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=82ba2500166, createdName=ms1467340776200723, createdTime=Tue Oct 17 07:34:00 CST 2017, time=2017-10-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1299109, encodeId=45ed1299109b7, content=<a href='/topic/show?id=2b85362063c' target=_blank style='color:#2F92EE;'>#单核细胞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=36206, encryptionId=2b85362063c, topicName=单核细胞)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=daa8281, createdName=雕雕, createdTime=Thu Aug 17 01:34:00 CST 2017, time=2017-08-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=233808, encodeId=e4432338086c, content=非常好的文章，学习了，很受益, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7LIiaRZTzJ3SEfiauCzTMPW7YvPPYLNJBXG9oh6Al1icq2VQQkIHWxqXehcicTS62YKJVBhxeth3wggw/0, createdBy=7ce01621306, createdName=天涯183, createdTime=Tue Aug 15 12:15:31 CST 2017, time=2017-08-15, status=1, ipAttribution=)]
    2017-08-15 天涯183

    非常好的文章，学习了，很受益

    0