Diabetic Med:英国约克郡1型糖尿病的儿童和青年人的死亡率和急性并发症研究

2018-03-25 MedSci MedSci原创

近日,国际杂志 《Diabetic Med》上在线发表一项关于英国约克郡1型糖尿病的儿童和青年人的死亡率和急性并发症的一项队列研究。研究基于人群的早发和晚发1型糖尿病人群的全因死亡率和特定原因死亡率。 本研究的对象为约克郡1978年至2013年间儿童和青少年糖尿病登记册诊断为早期1型糖尿病的(0-14岁)和晚期(15-29岁)的个体。该登记与来自于国建统计办公室的死亡证明数据相关能计算标准化

近日,国际杂志 《Diabetic Med》上在线发表一项关于英国约克郡1糖尿病儿童和青年人的死亡率和急性并发症的一项队列研究。研究基于人群的早发和晚发1糖尿病人群的全因死亡率和特定原因死亡率。

本研究的对象为约克郡1978年至2013年间儿童和青少年糖尿病登记册诊断为早期1型糖尿病的(0-14岁)和晚期(15-29岁)的个体。该登记与来自于国建统计办公室的死亡证明数据相关能计算标准化死亡率比率,使用Kaplan-Meier生存估计和Cox回归模型计算累积死亡率曲线。使用Onomap描述种族。剥夺指数使用汤森指数进行分类。每种情况下的死亡原因都经过临床验证。

研究共随访100 959/,5498人中有229人死亡。整体标准化死亡率为4.395CI 3.84.9)。根据发病年龄,性别或经济状况分析,标准化死亡率没有显著差异。白种人的标准化死亡率[8.195CI 6.99.4]显著高于南亚裔[3.495CI 1.76.4]诊断时间较晚年份(2002-2013年为早发型,2006 - 2013年为迟发型人群)的死亡率比较早年份(1991-1997年为早发型,1991-1997年迟发型)更低,两发病组的危险比为0.1395CI 0.05-0.33vs 0.2495CI 0.07-0.81)。

1型糖尿病患者的死亡人数仍然过多。尽管全因死亡率风险随着时间的推移而下降,但与急性并发症相关的死亡风险却没有改善。

原始出处:

T. C. Evans-Cheung, H. J. Bodansky, R. C. Parslowet al. Mortality and acute complications in children and young adults diagnosed with Type 1 diabetes in Yorkshire, UK: a cohort study

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createdName=1ddf0692m34(暂无匿称), createdTime=Sun Mar 25 18:01:43 CST 2018, time=2018-03-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=299583, encodeId=2f6e29958311, content=谢谢分享学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=69, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zMoyicyo6ia9f4IuLQAwZoxD6Hx4ibd5CMcOCYhStY6oDibbKK6O2X8iaicldO5ib8j1iapOIobIKCGiczU2A/0, createdBy=56251941490, createdName=虈亣靌, createdTime=Sun Mar 25 17:35:48 CST 2018, time=2018-03-25, status=1, ipAttribution=)]
    2018-07-08 丁鹏鹏
  4. 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createdBy=9a1a37427546, createdName=ms5439512287675881, createdTime=Thu Apr 26 06:14:00 CST 2018, time=2018-04-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1757963, encodeId=48991e579633d, content=<a href='/topic/show?id=84ba49031f9' target=_blank style='color:#2F92EE;'>#并发#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=49031, encryptionId=84ba49031f9, topicName=并发)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a27e37327108, createdName=丁鹏鹏, createdTime=Sun Jul 08 05:14:00 CST 2018, time=2018-07-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1638511, encodeId=b3a916385118e, content=<a href='/topic/show?id=afda591646' target=_blank style='color:#2F92EE;'>#DIA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5916, encryptionId=afda591646, topicName=DIA)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=987022654425, createdName=ms9608593228839890, createdTime=Tue Oct 02 19:14:00 CST 2018, time=2018-10-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1916801, encodeId=df411916801ba, content=<a href='/topic/show?id=f24198994a6' target=_blank style='color:#2F92EE;'>#青年人#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=98994, encryptionId=f24198994a6, topicName=青年人)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=284b425, createdName=zll0625, createdTime=Wed Dec 26 12:14:00 CST 2018, time=2018-12-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1608685, encodeId=882c1608685f1, content=<a href='/topic/show?id=eb6b1145939' target=_blank style='color:#2F92EE;'>#Med#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11459, encryptionId=eb6b1145939, topicName=Med)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=552a19396740, createdName=ms3994565386320060, createdTime=Tue Mar 27 07:14:00 CST 2018, time=2018-03-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=299673, encodeId=a32b2996e3b9, content=学习了.谢谢分享., beContent=null, objectType=article, channel=null, level=null, likeNumber=57, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/xkvRjYnJzzRJ2R0y7VhicibvkjPWHjIMmu4ZpKnE9cWAu4lVicS3uDUCfF4M4JWvrkrYfpb2KehPV0Ee29tPqyPEebBUibiaKhnvD/0, createdBy=f8412001184, createdName=惠映实验室, createdTime=Sun Mar 25 23:05:11 CST 2018, time=2018-03-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=299619, encodeId=af1c299619d1, content=近日.国际杂志<DiabeticMed>上在线发表一项关于英国约克郡1型糖尿病的儿童和青年人的死亡率和急性并发症的一项队列研究.研究基于人群的早发和晚发1型糖尿病人群的全因死亡率和特定原因死亡率., beContent=null, objectType=article, channel=null, level=null, likeNumber=76, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7cJ6ejWUr2nIia8qOvAKNdLHr32Df6G8iaoaOx6pHaoiacwp26DaslxZHCGbibZhhCGven4rvmWP60GahtzgFjgCjR/0, createdBy=6b111703011, createdName=有备才能无患, createdTime=Sun Mar 25 20:13:11 CST 2018, time=2018-03-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=299592, encodeId=adbf299592b5, content=学习了.长知识, beContent=null, objectType=article, channel=null, level=null, likeNumber=61, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220115/46bcf39c32de4aa6b45c5f9d66c8ee77/6cb4a20c55bb4b7691122f47747bfca2.jpg, createdBy=9dad1662329, createdName=1ddf0692m34(暂无匿称), createdTime=Sun Mar 25 18:01:43 CST 2018, time=2018-03-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=299583, encodeId=2f6e29958311, content=谢谢分享学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=69, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zMoyicyo6ia9f4IuLQAwZoxD6Hx4ibd5CMcOCYhStY6oDibbKK6O2X8iaicldO5ib8j1iapOIobIKCGiczU2A/0, createdBy=56251941490, createdName=虈亣靌, createdTime=Sun Mar 25 17:35:48 CST 2018, time=2018-03-25, status=1, ipAttribution=)]
  5. 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topicList=[TopicDto(id=5916, encryptionId=afda591646, topicName=DIA)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=987022654425, createdName=ms9608593228839890, createdTime=Tue Oct 02 19:14:00 CST 2018, time=2018-10-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1916801, encodeId=df411916801ba, content=<a href='/topic/show?id=f24198994a6' target=_blank style='color:#2F92EE;'>#青年人#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=98994, encryptionId=f24198994a6, topicName=青年人)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=284b425, createdName=zll0625, createdTime=Wed Dec 26 12:14:00 CST 2018, time=2018-12-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1608685, encodeId=882c1608685f1, content=<a href='/topic/show?id=eb6b1145939' target=_blank style='color:#2F92EE;'>#Med#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11459, encryptionId=eb6b1145939, topicName=Med)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=552a19396740, createdName=ms3994565386320060, createdTime=Tue Mar 27 07:14:00 CST 2018, time=2018-03-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=299673, encodeId=a32b2996e3b9, content=学习了.谢谢分享., beContent=null, objectType=article, channel=null, level=null, likeNumber=57, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/xkvRjYnJzzRJ2R0y7VhicibvkjPWHjIMmu4ZpKnE9cWAu4lVicS3uDUCfF4M4JWvrkrYfpb2KehPV0Ee29tPqyPEebBUibiaKhnvD/0, createdBy=f8412001184, createdName=惠映实验室, createdTime=Sun Mar 25 23:05:11 CST 2018, time=2018-03-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=299619, encodeId=af1c299619d1, content=近日.国际杂志<DiabeticMed>上在线发表一项关于英国约克郡1型糖尿病的儿童和青年人的死亡率和急性并发症的一项队列研究.研究基于人群的早发和晚发1型糖尿病人群的全因死亡率和特定原因死亡率., beContent=null, objectType=article, channel=null, level=null, likeNumber=76, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7cJ6ejWUr2nIia8qOvAKNdLHr32Df6G8iaoaOx6pHaoiacwp26DaslxZHCGbibZhhCGven4rvmWP60GahtzgFjgCjR/0, createdBy=6b111703011, createdName=有备才能无患, createdTime=Sun Mar 25 20:13:11 CST 2018, time=2018-03-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=299592, encodeId=adbf299592b5, content=学习了.长知识, beContent=null, objectType=article, channel=null, level=null, likeNumber=61, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220115/46bcf39c32de4aa6b45c5f9d66c8ee77/6cb4a20c55bb4b7691122f47747bfca2.jpg, createdBy=9dad1662329, createdName=1ddf0692m34(暂无匿称), createdTime=Sun Mar 25 18:01:43 CST 2018, time=2018-03-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=299583, encodeId=2f6e29958311, content=谢谢分享学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=69, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zMoyicyo6ia9f4IuLQAwZoxD6Hx4ibd5CMcOCYhStY6oDibbKK6O2X8iaicldO5ib8j1iapOIobIKCGiczU2A/0, createdBy=56251941490, createdName=虈亣靌, createdTime=Sun Mar 25 17:35:48 CST 2018, time=2018-03-25, status=1, ipAttribution=)]
    2018-12-26 zll0625
  6. 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encodeId=af1c299619d1, content=近日.国际杂志<DiabeticMed>上在线发表一项关于英国约克郡1型糖尿病的儿童和青年人的死亡率和急性并发症的一项队列研究.研究基于人群的早发和晚发1型糖尿病人群的全因死亡率和特定原因死亡率., beContent=null, objectType=article, channel=null, level=null, likeNumber=76, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7cJ6ejWUr2nIia8qOvAKNdLHr32Df6G8iaoaOx6pHaoiacwp26DaslxZHCGbibZhhCGven4rvmWP60GahtzgFjgCjR/0, createdBy=6b111703011, createdName=有备才能无患, createdTime=Sun Mar 25 20:13:11 CST 2018, time=2018-03-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=299592, encodeId=adbf299592b5, content=学习了.长知识, beContent=null, objectType=article, channel=null, level=null, likeNumber=61, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220115/46bcf39c32de4aa6b45c5f9d66c8ee77/6cb4a20c55bb4b7691122f47747bfca2.jpg, createdBy=9dad1662329, createdName=1ddf0692m34(暂无匿称), createdTime=Sun Mar 25 18:01:43 CST 2018, time=2018-03-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=299583, encodeId=2f6e29958311, content=谢谢分享学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=69, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zMoyicyo6ia9f4IuLQAwZoxD6Hx4ibd5CMcOCYhStY6oDibbKK6O2X8iaicldO5ib8j1iapOIobIKCGiczU2A/0, createdBy=56251941490, createdName=虈亣靌, createdTime=Sun Mar 25 17:35:48 CST 2018, time=2018-03-25, status=1, ipAttribution=)]
  7. 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createdName=1ddf0692m34(暂无匿称), createdTime=Sun Mar 25 18:01:43 CST 2018, time=2018-03-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=299583, encodeId=2f6e29958311, content=谢谢分享学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=69, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zMoyicyo6ia9f4IuLQAwZoxD6Hx4ibd5CMcOCYhStY6oDibbKK6O2X8iaicldO5ib8j1iapOIobIKCGiczU2A/0, createdBy=56251941490, createdName=虈亣靌, createdTime=Sun Mar 25 17:35:48 CST 2018, time=2018-03-25, status=1, ipAttribution=)]
    2018-03-25 惠映实验室

    学习了.谢谢分享.

    0

  8. 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createdName=1ddf0692m34(暂无匿称), createdTime=Sun Mar 25 18:01:43 CST 2018, time=2018-03-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=299583, encodeId=2f6e29958311, content=谢谢分享学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=69, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zMoyicyo6ia9f4IuLQAwZoxD6Hx4ibd5CMcOCYhStY6oDibbKK6O2X8iaicldO5ib8j1iapOIobIKCGiczU2A/0, createdBy=56251941490, createdName=虈亣靌, createdTime=Sun Mar 25 17:35:48 CST 2018, time=2018-03-25, status=1, ipAttribution=)]
    2018-03-25 有备才能无患

    近日.国际杂志上在线发表一项关于英国约克郡1型糖尿病的儿童和青年人的死亡率和急性并发症的一项队列研究.研究基于人群的早发和晚发1型糖尿病人群的全因死亡率和特定原因死亡率.

    0

  9. 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createdName=1ddf0692m34(暂无匿称), createdTime=Sun Mar 25 18:01:43 CST 2018, time=2018-03-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=299583, encodeId=2f6e29958311, content=谢谢分享学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=69, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zMoyicyo6ia9f4IuLQAwZoxD6Hx4ibd5CMcOCYhStY6oDibbKK6O2X8iaicldO5ib8j1iapOIobIKCGiczU2A/0, createdBy=56251941490, createdName=虈亣靌, createdTime=Sun Mar 25 17:35:48 CST 2018, time=2018-03-25, status=1, ipAttribution=)]
    2018-03-25 1ddf0692m34(暂无匿称)

    学习了.长知识

    0

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    2018-03-25 虈亣靌

    谢谢分享学习了

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