Gastric Cancer:胃切除术后连续血糖监测的实用价值

2020-07-04 MedSci原创 MedSci原创

以倾倒综合征为代表的胃切除术后的血糖波动是众所周知的胃切除术后综合征,会对患者的生活质量产生极大的负面影响。但是,胃切除术后当前的血糖监测方法不能全面地捕捉到手术后血糖波动的特征。

背景

以倾倒综合征为代表的胃切除术后的血糖波动是众所周知的胃切除术后综合征,会对患者的生活质量产生极大的负面影响。但是,胃切除术后当前的血糖监测方法不能全面地捕捉到手术后血糖波动的特征,因此,本项研究旨在研究胃切除术后连续血糖监测的实用价值。

 

方法

研究人员使用连续葡萄糖监测(CGM)系统记录进行胃切除术的患者的血糖状况,并比较进行远端胃切除术(DG)和全胃切除术(TG)的患者的血糖状况。为了评估胃切除术后综合症,包括倾倒综合征,研究人员使用了胃切除术后综合症评估量表37项问卷并比较了血糖曲线差异。

 

结果

研究人员将2017年9月至2019年9月期间接受过DG的57例患者和接受TG的13例患者纳入研究。结果显示,胃切除术后昼夜血糖变异性大,夜间低血糖时间更长。TG的倾倒综合征得分比DG组差(TG 2.4±1.4 VS  DG 1.3±1.2,P= 0.0061)。重要的是,57例DG患者中有30例(52.6%)和13例TG患者中有5例(38.5%)在没有高血糖症状的情况下经历了餐后低血糖。倾倒症状评分与血糖变异性之间没有相关性(ρ=0.0545,P = 0.6662)。

 

结论

CGM在接受胃切除术的患者中表现出昼夜血糖变化和夜间低血糖。由于某些低血糖患者未出现症状,血糖变化不一定与倾倒症状相关,因此倾倒综合征只能部分解释术后血糖波动。

原始出处:

Takeshi Kubota. Et al. Utility of continuous glucose monitoring following gastrectomy. Gastric Cancer.2020.

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    2020-10-28 skhzy
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    2021-02-08 许安
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    2020-07-06 bshuang
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