新研究阐明膝骨关节炎原因 工程院院士提出微创治疗方案

2019-06-18 张素 陈晨 中国新闻网

记者18日采访中国工程院院士、河北医科大学第三医院院长张英泽的科研团队获悉,他们创新提出的微创保膝治疗方案已在270余所医院开展临床治疗,治疗患者数千例。

记者18日采访中国工程院院士、河北医科大学第三医院院长张英泽的科研团队获悉,他们创新提出的微创保膝治疗方案已在270余所医院开展临床治疗,治疗患者数千例。
 
年纪大了,为什么上下台阶时膝关节易疼痛,还容易“O”形腿?这种由骨质疏松引发的关节失衡,最终可能导致膝关节骨性关节炎(KOA)。2015年发布的《中国骨关节炎防治白皮书》指出,国内约有1.5亿人患病,其中多数为KOA发病人群,且随着人口不断老龄化,膝骨关节炎的发病人群基数会不断扩大。
 
张英泽表示,在65岁以上人群中约有46%的老年人患有不同程度的骨关节炎。既往医学研究认为,膝关节骨性关节炎是关节软骨磨损所导致。经过解剖学、影像学、生物力学和临床研究,他们在膝关节骨性关节炎的病因和微创治疗方面取得新的进展。
 
首先,他们在系列骨科研究中引入了力学原理,提出了骨骼的“差异性沉降”理论,从骨骼的受力原理上阐明了膝关节骨性关节炎的病因。
 
“‘差异性沉降’也称‘不均匀沉降’,是物体受到重力影响而发生的一种力学现象,在自然界普遍存在。例如路面偶尔会出现的塌陷、房屋向一侧倾倒等。”张英泽解释说,人体骨骼由于受到重力影响,也会出现“不均匀沉降”,当人体骨骼出现骨质疏松,疏松的部分就可能会在体重压力之下出现“微骨折”,当这些“微骨折”日积月累,就会造成骨骼塌陷、下沉、关节变形等病变。
 
他进一步指出,这种“不均匀沉降”现象在脊柱、胫骨近端最为显著和典型。胫骨平台内侧承受人体的负重的2/3,平台外侧承重1/3,而且外侧由几乎不发生骨质疏松的腓骨支撑。因此,当平台内侧骨骼骨质疏松并发生不均匀沉降,高度下降,低于外侧,压力分布更加不均衡,进一步加重了磨损,从而诱发膝关节骨性关节炎。
 
在明确了膝关节骨性关节炎的发病原因和过程后,专家由此提出,可通过截断腓骨的微创保膝手术使胫骨平台的内外侧载荷恢复平衡,缓解疼痛,恢复关节功能,同时避免了关节置换手术。
 
张英泽及其团队还自主研发了“膝关节平衡支撑可吸收垫片”,用于膝关节骨性关节炎的治疗。这种可吸收垫片由I型胶原蛋白和羟基磷灰石聚合而成,是通过食品药品监督管理局(FDA)认证的医用材料。
 
目前,上述科研成果已在中国人民解放军总医院、上海长征医院、大连医科大学附属第一医院等医院开展了前瞻性研究并在临床应用。据介绍,该成果还在日本、韩国、古巴、乌克兰等国应用于治疗膝关节骨性关节炎患者,有医生评价称“腓骨截骨术是一项方便应用的新技术,对日益突出的老龄化问题有重要意义”。

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    2020-02-10 lisa438
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  5. 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  6. 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    2019-06-20 lmm397
  7. 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    2019-06-20 vera_1203
  9. 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    2019-06-19 junJUN

    院士是学术至高点,也是大家必争之地呀

    0

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