IBD:术后IL-6能预测克罗恩病患者选择性手术后早期腹腔感染的发生

2018-08-27 MedSci MedSci原创

白细胞介素-6(IL-6)在预测克罗恩病(CD)患者腹腔内脓毒症并发症(IASCs)中的作用目前仍不清楚。本项研究评估了CD患者的血清IL-6时程及其与术后IASCs的相关性。

背景
白细胞介素-6(IL-6)在预测克罗恩病(CD)患者腹腔内脓毒症并发症(IASCs)中的作用目前仍不清楚。本项研究评估了CD患者的血清IL-6时程及其与术后IASCs的相关性。

方法
本项总共对118例接受CD手术的患者进行了前瞻性评估。他们分为IASC组和非IASC组。多变量分析用于识别风险因素,并进行接受者操作特征曲线分析。

结果
多变量分析显示,术后第一天(POD)的高IL-6浓度> 137.25 pg / mL与IASCs独立相关(优势比,5.74; 95%置信区间[CI],1.46-22.67; P = 0.012),IL-6高的患者术后住院时间较长(6天vs 9天,P <0.001)。手术与IASC之间的中位间隔(四分位间距)为6(4-22)天,在POD 1,3和5上有和没有IASC的患者之间的IL-6浓度显着不同。用于预测术后IASCs的理想的IL-6截止值为137.25 pg / mL,敏感性为81%,特异性为58%,曲线下面积为0.71(95%CI,0.59-0.83),阴性预测值为0.93。

结论
CD患者术后第一天的高IL-6浓度与术后IASCs的发生独立相关,并且与C-反应蛋白相比可以更加对IASC进行早期诊断和早期干预。

原始出处:

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    2019-08-20 146cf0f6m18暂无昵称

    不错不错,学习了

    0

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    2018-08-29 bnurmamat
  5. [GetPortalCommentsPageByObjectIdResponse(id=371552, encodeId=3c9c3e1552e4, content=不错不错,学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=50, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d3165168192, createdName=146cf0f6m18暂无昵称, createdTime=Tue Aug 20 15:33:31 CST 2019, time=2019-08-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2028463, encodeId=f71620284637a, content=<a href='/topic/show?id=c9b38559517' target=_blank style='color:#2F92EE;'>#腹腔感染#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=85595, encryptionId=c9b38559517, topicName=腹腔感染)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f13d475, createdName=mashirong, createdTime=Thu Nov 22 22:43:00 CST 2018, time=2018-11-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1922914, encodeId=bfc419229145f, content=<a href='/topic/show?id=78f794e800a' target=_blank style='color:#2F92EE;'>#选择性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=94780, encryptionId=78f794e800a, topicName=选择性)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a0802500050, createdName=肉我只吃一口, createdTime=Fri Jul 12 07:43:00 CST 2019, time=2019-07-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1263481, encodeId=d7a21263481b3, content=<a href='/topic/show?id=75bc930217' target=_blank style='color:#2F92EE;'>#IBD#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=22, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=9302, encryptionId=75bc930217, topicName=IBD)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=fc0372, createdName=bnurmamat, createdTime=Wed Aug 29 01:43:00 CST 2018, time=2018-08-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1273777, encodeId=174712e37772a, content=<a href='/topic/show?id=fae896e7ea' target=_blank style='color:#2F92EE;'>#IL-6#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=9677, encryptionId=fae896e7ea, topicName=IL-6)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f984116, createdName=kzlchina, createdTime=Wed Aug 29 01:43:00 CST 2018, time=2018-08-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=341186, encodeId=7255341186e2, content=哈哈哈,学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=42, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e1ee1608797, createdName=huangshang9812, createdTime=Mon Aug 27 14:42:43 CST 2018, time=2018-08-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=341116, encodeId=e7c234111610, content=哈哈哈,学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e1ee1608797, createdName=huangshang9812, createdTime=Mon Aug 27 14:12:39 CST 2018, time=2018-08-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=341108, encodeId=9be234110876, content=学习了,谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=43, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7c592194322, createdName=1209e435m98(暂无昵称), createdTime=Mon Aug 27 13:54:14 CST 2018, time=2018-08-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=341091, encodeId=e6cb34109157, content=嗯嗯,学习了。, beContent=null, objectType=article, channel=null, level=null, likeNumber=51, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2018/07/16/3b24606172648eea459125cb74754afe.jpg, createdBy=6c022216608, createdName=liumin1987, createdTime=Mon Aug 27 11:28:17 CST 2018, time=2018-08-27, status=1, ipAttribution=)]
    2018-08-29 kzlchina
  6. [GetPortalCommentsPageByObjectIdResponse(id=371552, encodeId=3c9c3e1552e4, content=不错不错,学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=50, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d3165168192, createdName=146cf0f6m18暂无昵称, createdTime=Tue Aug 20 15:33:31 CST 2019, time=2019-08-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2028463, encodeId=f71620284637a, content=<a href='/topic/show?id=c9b38559517' target=_blank style='color:#2F92EE;'>#腹腔感染#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=85595, encryptionId=c9b38559517, topicName=腹腔感染)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f13d475, createdName=mashirong, createdTime=Thu Nov 22 22:43:00 CST 2018, time=2018-11-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1922914, encodeId=bfc419229145f, content=<a href='/topic/show?id=78f794e800a' target=_blank style='color:#2F92EE;'>#选择性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=94780, encryptionId=78f794e800a, topicName=选择性)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a0802500050, createdName=肉我只吃一口, createdTime=Fri Jul 12 07:43:00 CST 2019, time=2019-07-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1263481, encodeId=d7a21263481b3, content=<a href='/topic/show?id=75bc930217' target=_blank style='color:#2F92EE;'>#IBD#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=22, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=9302, encryptionId=75bc930217, topicName=IBD)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=fc0372, createdName=bnurmamat, createdTime=Wed Aug 29 01:43:00 CST 2018, time=2018-08-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1273777, encodeId=174712e37772a, content=<a href='/topic/show?id=fae896e7ea' target=_blank style='color:#2F92EE;'>#IL-6#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=9677, encryptionId=fae896e7ea, topicName=IL-6)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f984116, createdName=kzlchina, createdTime=Wed Aug 29 01:43:00 CST 2018, time=2018-08-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=341186, encodeId=7255341186e2, content=哈哈哈,学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=42, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e1ee1608797, createdName=huangshang9812, createdTime=Mon Aug 27 14:42:43 CST 2018, time=2018-08-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=341116, encodeId=e7c234111610, content=哈哈哈,学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e1ee1608797, createdName=huangshang9812, createdTime=Mon Aug 27 14:12:39 CST 2018, time=2018-08-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=341108, encodeId=9be234110876, content=学习了,谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=43, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7c592194322, createdName=1209e435m98(暂无昵称), createdTime=Mon Aug 27 13:54:14 CST 2018, time=2018-08-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=341091, encodeId=e6cb34109157, content=嗯嗯,学习了。, beContent=null, objectType=article, channel=null, level=null, likeNumber=51, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2018/07/16/3b24606172648eea459125cb74754afe.jpg, createdBy=6c022216608, createdName=liumin1987, createdTime=Mon Aug 27 11:28:17 CST 2018, time=2018-08-27, status=1, ipAttribution=)]
    2018-08-27 huangshang9812

    哈哈哈,学习了

    0

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    2018-08-27 huangshang9812

    哈哈哈,学习了

    0

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    2018-08-27 1209e435m98(暂无昵称)

    学习了,谢谢分享

    0

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    2018-08-27 liumin1987

    嗯嗯,学习了。

    0